Number of apoptotic cells as a prognostic marker in invasive breast cancer.

Abstract:

:Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number of apoptotic cells in ten high-power fields were converted to the number of apoptotic cells per mm2 to obtain the apoptotic index (AI). The AI showed a positive correlation to the mitotic activity index (MAI) (P = 0.0001), histological grade (P < 0.0001) and worse tumour differentiation. Patients with high AI showed shorter overall survival than patients with low AI in the total group as well as in the lymph node-positive group. Tumour size, MAI, lymph node status and AI were independent prognostic indicators in multivariate analysis. The AI was shown to be of additional prognostic value to the MAI in the total patients group as well as in the lymph node-positive group. The correlation between the AI and the MAI points to linked mechanisms of apoptosis and proliferation. Since apoptotic cells can be counted with good reproducibility in H&E-stained tumour sections, the AI may be used as an additional prognostic indicator in invasive breast cancer.

journal_name

Br J Cancer

authors

de Jong JS,van Diest PJ,Baak JP

doi

10.1054/bjoc.1999.0928

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

368-73

issue

2

eissn

0007-0920

issn

1532-1827

pii

S000709209990928X

journal_volume

82

pub_type

杂志文章
  • In vitro testing of chemotherapeutic drug combinations in acute myelocytic leukaemia using the fluorometric microculture cytotoxicity assay (FMCA).

    abstract::The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/bjc.1993.178

    authors: Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

    更新日期:1993-05-01 00:00:00

  • Detection of somatic changes in human cancer DNA by DNA fingerprint analysis.

    abstract::Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1987.71

    authors: Thein SL,Jeffreys AJ,Gooi HC,Cotter F,Flint J,O'Connor NT,Weatherall DJ,Wainscoat JS

    更新日期:1987-04-01 00:00:00

  • Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents.

    abstract::The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6601218

    authors: Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

    更新日期:2003-10-06 00:00:00

  • Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15.

    abstract::The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.176

    authors: García-Rocha M,García-Gravalos MD,Avila J

    更新日期:1996-04-01 00:00:00

  • The role of radiotherapy after chemotherapy in the management of persistent para-aortic nodal disease in non-seminomatous germ cell tumours.

    abstract::In the years 1979-1982, 83 patients with malignant teratoma of the testis who had retroperitoneal adenopathy at presentation or after a period of surveillance were treated. Complete radiological resolution of disease was obtained in 34 patients and a residual mass remained in 26, the remainder having progression of th...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1986.105

    authors: Read G,Johnson RJ,Wilkinson PM

    更新日期:1986-05-01 00:00:00

  • Breast cancer risk among first-generation migrants in the Netherlands.

    abstract::We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6601821

    authors: Visser O,van der Kooy K,van Peppen AM,Ory FG,van Leeuwen FE

    更新日期:2004-06-01 00:00:00

  • Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer.

    abstract::Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.675

    authors: Ostrowski J,Trzeciak L,Kołodziejski J,Bomsztyk K

    更新日期:1998-11-01 00:00:00

  • Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice.

    abstract::In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers. A single hepatonecrotic dose of CCl4 24 h before a single dose of DEN also increased the number of tumour...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1978.89

    authors: Poound AW,McGuire LJ

    更新日期:1978-04-01 00:00:00

  • Cellular pharmacology of a liposomal preparation of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine, a lipophilic derivative of 1-beta-D-arabinofuranosylcytosine.

    abstract::The in vitro deamination, cytotoxicity, cellular drug uptake, distribution and cellular pharmacology in HL-60 cells of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a lipophilic derivative of arabinofuranosylcytosine (ara-C), were studied. Compared with ara-C, NHAC in liposomal formulations was highly resista...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1995.185

    authors: Horber DH,Schott H,Schwendener RA

    更新日期:1995-05-01 00:00:00

  • Sentinel node biopsy in early vulvar cancer.

    abstract::Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This st...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.1999.0918

    authors: De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli G

    更新日期:2000-01-01 00:00:00

  • Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival.

    abstract::A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1989.156

    authors: Dazzi H,Hasleton PS,Thatcher N,Barnes DM,Wilkes S,Swindell R,Lawson RA

    更新日期:1989-05-01 00:00:00

  • Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments.

    abstract:BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605785

    authors: Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

    更新日期:2010-08-24 00:00:00

  • The effect of Corynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients.

    abstract::Detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with Corynebacterium parvum (C. parvum). These patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. They all received an initial i.v. inf...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1975.229

    authors: James K,Clunie GJ,Woodruff MF,McBride WH,Stimson WH,Drew R,Catty D

    更新日期:1975-09-01 00:00:00

  • Serum CA549 in primary breast cancer: comparison with CA15.3 and MCA.

    abstract::We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1994.136

    authors: Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

    更新日期:1994-04-01 00:00:00

  • The prognostic significance of immune microenvironment in breast ductal carcinoma in situ.

    abstract:BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0797-7

    authors: Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

    更新日期:2020-05-01 00:00:00

  • A controlled "before-after" study: impact of a clinical guidelines programme and regional cancer network organization on medical practice.

    abstract::A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6600057

    authors: Ray-Coquard I,Philip T,de Laroche G,Froger X,Suchaud JP,Voloch A,Mathieu-Daudé H,Fervers B,Farsi F,Browman GP,Chauvin F

    更新日期:2002-02-01 00:00:00

  • Spinal cord compression in small cell lung cancer: a retrospective study of 610 patients.

    abstract::The records of 610 consecutive patients with small cell lung cancer, treated on a common protocol in a multicentre trial, were reviewed and 24 (4%) cases of spinal cord compression identified. Five hundred patients had isotope bone scans performed at presentation, and in 131 (26%) there was abnormal isotope uptake in ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1989.119

    authors: Goldman JM,Ash CM,Souhami RL,Geddes DM,Harper PG,Spiro SG,Tobias JS

    更新日期:1989-04-01 00:00:00

  • Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation.

    abstract::Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the DNA-PK complex, i.e....

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.2000.1258

    authors: Vaganay-Juéry S,Muller C,Marangoni E,Abdulkarim B,Deutsch E,Lambin P,Calsou P,Eschwege F,Salles B,Joiner M,Bourhis J

    更新日期:2000-08-01 00:00:00

  • Foscan (mTHPC) photosensitized macrophage activation: enhancement of phagocytosis, nitric oxide release and tumour necrosis factor-alpha-mediated cytolytic activity.

    abstract::Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6690648

    authors: Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

    更新日期:1999-09-01 00:00:00

  • Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.

    abstract:BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2012.27

    authors: Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

    更新日期:2012-02-28 00:00:00

  • Surveillance for endometrial cancer with transvaginal ultrasonography of breast cancer patients under tamoxifen treatment.

    abstract::The association of endometrial thickness with the risk of developing endometrial cancer (EC) within 2 years was investigated in a consecutive cohort of 1205 breast cancer patients under tamoxifen treatment, undergoing transvaginal ultrasonography (TVUS) for follow-up purpose (asymptomatic, 1068) or for abnormal uterin...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6600894

    authors: Ciatto S,Cecchini S,Gervasi G,Landini A,Zappa M,Crocetti E

    更新日期:2003-04-22 00:00:00

  • Phase Ib study of CP-868,596, a PDGFR inhibitor, combined with docetaxel with or without axitinib, a VEGFR inhibitor.

    abstract:BACKGROUND:Tumoural interstitial hypertension, possibly modulated by platelet-derived and vascular endothelial growth factor receptors (PDGFR and VEGFR), may mediate resistance to chemotherapy. METHODS:Forty-eight patients with advanced solid tumours received oral PDGFR inhibitor CP-868,596 (60-100 mg twice daily (BID...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1038/sj.bjc.6605941

    authors: Michael M,Vlahovic G,Khamly K,Pierce KJ,Guo F,Olszanski AJ

    更新日期:2010-11-09 00:00:00

  • The influence of timing of radiation therapy following breast-conserving surgery on 10-year disease-free survival.

    abstract:BACKGROUND:The Dutch guidelines advise to start radiation therapy (RT) within 5 weeks following breast-conserving surgery (BCS). However, much controversy exists regarding timing of RT. This study investigated its effect on 10-year disease-free survival (DFS) in a Dutch population-based cohort. METHODS:All women diagn...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2017.159

    authors: van Maaren MC,Bretveld RW,Jobsen JJ,Veenstra RK,Groothuis-Oudshoorn CG,Struikmans H,Maduro JH,Strobbe LJ,Poortmans PM,Siesling S

    更新日期:2017-07-11 00:00:00

  • The impact of patient comorbidity on cancer stage at diagnosis.

    abstract:BACKGROUND:It is known that cancer stage is affected by comorbidity, but the evidence regarding the magnitude and even direction of this effect is highly inconsistent and poorly understood. The aims of this study were to establish the impact of comorbidity on cancer stage at diagnosis, using both specific individual co...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2015.355

    authors: Gurney J,Sarfati D,Stanley J

    更新日期:2015-11-03 00:00:00

  • Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.

    abstract::A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1979.173

    authors: Higgins PJ,Tong C,Borenfreund E,Okin RS,Bendich A

    更新日期:1979-08-01 00:00:00

  • Understanding the cancer stem cell.

    abstract::The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it was initially believed that only a rare population of stem cells are able to undergo self-renewing divisions and differentiate to form all populations within a malignancy, a recent work has shown that these cells may not be ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bjc.6605821

    authors: Bomken S,Fiser K,Heidenreich O,Vormoor J

    更新日期:2010-08-10 00:00:00

  • Variable susceptibility to NK activity of cloned cell lines derived from a primary rat rhabdomyosarcoma: relationship to metastatic potential.

    abstract::In vitro cloned lines derived from a primary nickel-induced rat rhabdomyosarcoma exhibited diverse levels of susceptibility to spontaneous NK activity. The presence of NK target structures was revealed by competition assays on all cloned cell lines, and the NK susceptibility of the tumour lines varied according to the...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1983.159

    authors: Poupon MF,Judde JG,Pot-Deprun J,Sweeney F,Lespinats G

    更新日期:1983-07-01 00:00:00

  • Cell kinetic analysis of murine squamous cell carcinomas: a comparison of single versus double labelling using flow cytometry and immunohistochemistry.

    abstract::The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1993.487

    authors: Schultz-Hector S,Begg AC,Hofland I,Kummermehr J,Sund M

    更新日期:1993-12-01 00:00:00

  • Somatic-cell hybrids producing antibodies against CEA.

    abstract::Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen. A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer det...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1981.1

    authors: Rogers GT,Rawlins GA,Bagshawe KD

    更新日期:1981-01-01 00:00:00

  • Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride.

    abstract::Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours for...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1973.57

    authors: Pound AW,Lawson TA,Horn L

    更新日期:1973-06-01 00:00:00