Haemoglobin adducts formed by aromatic amines in smokers: sources of inter-individual variability.

abstract：BACKGROUND:This phase 1 study examined the safety, tolerability, pharmacokinetics and preliminary efficacy of eribulin-liposomal formulation (eribulin-LF) in patients with advanced solid tumours. METHODS:Eligible patients with ECOG PS 0-1 were treated with eribulin-LF either on day 1 every 21 days (Schedule 1), or on ...

journal_title：British journal of cancer

authors： Evans TRJ,Dean E,Molife LR,Lopez J,Ranson M,El-Khouly F,Zubairi I,Savulsky C,Reyderman L,Jia Y,Sweeting L,Greystoke A,Barriuso J,Kristeleit R

更新日期：2019-02-01 00:00:00

abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...

journal_title：British journal of cancer

authors： Ito I,Minegishi T,Fukuda J,Shinozaki H,Auersperg N,Leung PC

更新日期：2000-04-01 00:00:00

abstract：:To understand genetic events which play a role in the development and/or progression of human endometrial cancer, we studied allelotypes on all autosomal chromosomes, as well as chromosome X, with 42 microsatellite markers and 56 endometrial cancers. The most frequent loss of heterozygosity (LOH) was observed on the l...

journal_title：British journal of cancer

authors： Nagase S,Sato S,Tezuka F,Wada Y,Yajima A,Horii A

更新日期：1996-12-01 00:00:00

abstract：:High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...

journal_title：British journal of cancer

authors： Boland I,Vassal G,Morizet J,Terrier-Lacombe MJ,Valteau-Couanet D,Kalifa C,Hartmann O,Gouyette A

更新日期：1999-02-01 00:00:00

abstract：:A case-control study from Uganda found that the risk of Kaposi's sarcoma increased with increasing titre of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) latent nuclear antigens, independently of HIV infection. Clinically, widespread Kaposi's sarcoma was more frequent among patients with HIV infect...

journal_title：British journal of cancer

authors： Newton R,Ziegler J,Bourboulia D,Casabonne D,Beral V,Mbidde E,Carpenter L,Parkin DM,Wabinga H,Mbulaiteye S,Jaffe H,Weiss R,Boshoff C

更新日期：2003-08-04 00:00:00

abstract：BACKGROUND:Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated...

journal_title：British journal of cancer

authors： Lesnock JL,Darcy KM,Tian C,Deloia JA,Thrall MM,Zahn C,Armstrong DK,Birrer MJ,Krivak TC

更新日期：2013-04-02 00:00:00

abstract：:The objective of the study was to evaluate the effect of neoadjuvant chemotherapy on the survival of patients with oropharyngeal cancer. Patients with a squamous cell carcinoma of the oropharynx for whom curative radiotherapy or surgery was considered feasible were entered in a multicentric randomized trial comparing ...

journal_title：British journal of cancer

authors： Domenge C,Hill C,Lefebvre JL,De Raucourt D,Rhein B,Wibault P,Marandas P,Coche-Dequeant B,Stromboni-Luboinski M,Sancho-Garnier H,Luboinski B,French Groupe d'Etude des Tumeurs de la Tête et du Cou (GETTEC).

更新日期：2000-12-01 00:00:00

abstract：:Age distributions of parents at birth of patients registered in the National Wilms' Tumour Study were compared to those of the general population. An increasing incidence of sporadic Wilms' tumour with increasing paternal age was found, with a relative risk of 2.1 of tumour in children of fathers over 55 compared to c...

journal_title：British journal of cancer

authors： Olson JM,Breslow NE,Beckwith JB

更新日期：1993-04-01 00:00:00

abstract：:Detailed data and statistics per each morphological site of various digestive neoplasms were obtained for the period 1976-87 from the Vaud Cancer Registry datafile, a population-based cancer registration scheme covering about 530,000 inhabitants from the French-speaking part of Switzerland. Tabulations presented inclu...

journal_title：British journal of cancer

authors： Levi F,La Vecchia C,Franceschi S,Te VC

更新日期：1991-04-01 00:00:00

abstract：:We developed a decision aid (DA) for patients with metastatic non-small cell lung cancer (NSCLC), to better inform patients of their prognosis and treatment options, and facilitate involvement in decision-making. In a pilot study, 20 patients with metastatic NSCLC attending outpatient clinics at a major cancer centre,...

journal_title：British journal of cancer

authors： Leighl NB,Shepherd FA,Zawisza D,Burkes RL,Feld R,Waldron J,Sun A,Payne D,Bezjak A,Tattersall MH

更新日期：2008-06-03 00:00:00

abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

journal_title：British journal of cancer

authors： Pickthall VJ

更新日期：1976-09-01 00:00:00

abstract：:A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...

journal_title：British journal of cancer

authors： Oza AM,Ganesan TS,Dorreen M,Johnson PW,Waxman J,Gregory W,Lim J,Wright J,Dadiotis L,Barbounis V

更新日期：1992-03-01 00:00:00

abstract：:In order to examine in detail the sensitivity to chemotherapy of tumour cells at various organ sites and at various stages of metastasis, we have used a series of cell lines, all selected from sister subpopulations derived from a single mouse mammary tumour, which can be distinguished and quantitated from normal cells...

journal_title：British journal of cancer

authors： Miller BE,Miller FR,Machemer T,Heppner GH

更新日期：1993-07-01 00:00:00

abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

journal_title：British journal of cancer

authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

更新日期：1995-09-01 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...

journal_title：British journal of cancer

authors： Pavlenko M,Roos AK,Lundqvist A,Palmborg A,Miller AM,Ozenci V,Bergman B,Egevad L,Hellström M,Kiessling R,Masucci G,Wersäll P,Nilsson S,Pisa P

更新日期：2004-08-16 00:00:00

abstract：BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...

journal_title：British journal of cancer

authors： Cocco E,Bellone S,El-Sahwi K,Cargnelutti M,Casagrande F,Buza N,Tavassoli FA,Siegel ER,Visintin I,Ratner E,Silasi DA,Azodi M,Schwartz PE,Rutherford TJ,Pecorelli S,Santin AD

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:The distinct expression pattern of tumour-associated antigens (TAAs) might be a critical reason for the inefficacy of immunity-based treatments and heterogeneous postsurgical recovery in patients with solid tumours, including hepatocellular carcinoma (HCC). However, little is known about the clinical value o...

journal_title：British journal of cancer

authors： Liang J,Ding T,Guo ZW,Yu XJ,Hu YZ,Zheng L,Xu J

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...

journal_title：British journal of cancer

authors： Alì G,Boldrini L,Lucchi M,Picchi A,Dell'Omodarme M,Prati MC,Mussi A,Corsi V,Fontanini G

更新日期：2009-12-01 00:00:00

abstract：:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...

journal_title：British journal of cancer

authors： van Rijn J,van den Berg J,Teerlink T,Kruyt FA,Schor DS,Renardel de Lavalette AC,van den Berg TK,Jakobs C,Slotman BJ

更新日期：2003-02-10 00:00:00

abstract：:Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60-70%, mainly limited by disease progression. The effect of PVE on tumour growth rate has not been investigated. The objective of this study was to compar...

journal_title：British journal of cancer

authors： Pamecha V,Levene A,Grillo F,Woodward N,Dhillon A,Davidson BR

更新日期：2009-02-24 00:00:00

abstract：BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...

journal_title：British journal of cancer

authors： Masuda S,Kadowaki T,Kumaki N,Tang X,Tokuda Y,Yoshimura S,Takekoshi S,Osamura RY

更新日期：2012-12-04 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where su...

journal_title：British journal of cancer

authors： Lear JT,Corner C,Dziewulski P,Fife K,Ross GL,Varma S,Harwood CA

更新日期：2014-10-14 00:00:00

abstract：:Tamoxifen is the current therapy of choice for patients with oestrogen receptor positive breast cancer, and it is currently under evaluation as a prophylactic for women at high risk of developing the disease. However, tamoxifen is also known to induce proliferative changes in the endometrium increasing the risk of dev...

journal_title：British journal of cancer

authors： Hague S,Manek S,Oehler MK,MacKenzie IZ,Bicknell R,Rees MC

更新日期：2002-03-04 00:00:00

abstract：:We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including th...

journal_title：British journal of cancer

authors： Betts DR,Leibundgut KE,Feldges A,Plüss HJ,Niggli FK

更新日期：1998-02-01 00:00:00

abstract：:Heterogeneity of DNA content in multiple hepatocellular carcinomas (HCCs) was investigated by flow cytometry in 62 tumours from 26 patients who had undergone surgical treatment for multiple synchronous HCCs. Heterogeneity of DNA content was defined (a) when tumours had a different DNA ploidy pattern or (b) when the di...

journal_title：British journal of cancer

authors： Hui AM,Kawasaki S,Imamura H,Miyagawa S,Ishii K,Katsuyama T,Makuuchi M

更新日期：1997-01-01 00:00:00

abstract：:PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKC delta and inhibiting PKC alpha. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other anticancer agents in a panel of 10 human cancer cell lines characterised for expr...

journal_title：British journal of cancer

authors： Benhadji KA,Serova M,Ghoul A,Cvitkovic E,Le Tourneau C,Ogbourne SM,Lokiec F,Calvo F,Hammel P,Faivre S,Raymond E

更新日期：2008-12-02 00:00:00

abstract：:Accuracy in the assessment of performance status by oncologists has not been well evaluated. We investigated possible discrepancies in the assessment of performance status among patients, nurses, and oncologists, and evaluated the prognostic importance of each assessment. Two hundred and six inpatients with inoperable...

journal_title：British journal of cancer

authors： Ando M,Ando Y,Hasegawa Y,Shimokata K,Minami H,Wakai K,Ohno Y,Sakai S

更新日期：2001-11-30 00:00:00

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：:Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and spec...

journal_title：British journal of cancer

authors： Beckermann BM,Kallifatidis G,Groth A,Frommhold D,Apel A,Mattern J,Salnikov AV,Moldenhauer G,Wagner W,Diehlmann A,Saffrich R,Schubert M,Ho AD,Giese N,Büchler MW,Friess H,Büchler P,Herr I

更新日期：2008-08-19 00:00:00

abstract：:Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...

journal_title：British journal of cancer

authors： Purohit A,Budai B,Wang DY,Willemsen EL,de Winkel A,Parish D,Ghilchik MW,Szamel I,Reed MJ

更新日期：2000-01-01 00:00:00