Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.

abstract：:Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution de...

journal_title：British journal of cancer

authors： Goldberg JA,Thomson JA,Bradnam MS,Fenner J,Bessent RG,McKillop JH,Kerr DJ,McArdle CS

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...

journal_title：British journal of cancer

authors： Hopwood P,Stephens RJ

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...

journal_title：British journal of cancer

authors： Klimowicz AC,Bose P,Petrillo SK,Magliocco AM,Dort JC,Brockton NT

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:This paper reports on an ongoing primary care audit of cancer referrals undertaken in Scotland in 2006-2007 and 2007-2008. METHODS:General practitioners (GPs) in Scotland were asked to review all new cancer diagnoses within their practice during the preceding year. RESULTS:4181 patients were identified i...

journal_title：British journal of cancer

authors： Baughan P,O'Neill B,Fletcher E

更新日期：2009-12-03 00:00:00

abstract：BACKGROUND:Dysplasia is a marker of cancer risk in Barrett's oesophagus (BO), but this risk is variable and diagnosis is subject to inter-observer variability. Cancer risk in BO is increased when chromosomal instability is present. Nucleotyping (NT) is a new method that uses high-resolution digital images of nuclei to ...

journal_title：British journal of cancer

authors： Dunn JM,Hveem T,Pretorius M,Oukrif D,Nielsen B,Albregtsen F,Lovat LB,Novelli MR,Danielsen HE

更新日期：2011-10-11 00:00:00

abstract：:The photodynamic effects of sulphonated aluminium phthalocyanine (SALPC) have been compared on cultured AR4-2J cells of a pancreatic carcinoma cell line and on exocrine cells of the normal phenotype freshly isolated from the rat pancreas; a multi-channel perifusion system was used for this kinetic study in vitro. Wher...

journal_title：British journal of cancer

authors： Matthews EK,Cui ZJ

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Panobinostat, a pan-deacetylase inhibitor, overcomes imatinib resistance in preclinical models of gastrointestinal stromal tumours (GIST). Here we determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of panobinostat in combination with imatinib (IM) for treatment of patients with re...

journal_title：British journal of cancer

authors： Bauer S,Hilger RA,Mühlenberg T,Grabellus F,Nagarajah J,Hoiczyk M,Reichardt A,Ahrens M,Reichardt P,Grunewald S,Scheulen ME,Pustowka A,Bock E,Schuler M,Pink D

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:Tumour heterogeneity is documented for many characters, including the production of growth factors, one of the hallmarks of cancer. What maintains heterogeneity remains an open question that has implications for diagnosis and treatment, as drugs that target growth factors are susceptible to the evolution of ...

journal_title：British journal of cancer

authors： Archetti M

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) is associated with decreased adhesion and acquisition of metastatic potential of breast cancer cells. Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the Notch signaling path...

journal_title：British journal of cancer

authors： Chen J,Imanaka N,Chen J,Griffin JD

更新日期：2010-01-19 00:00:00

abstract：:In a blind study, 518 serum samples were assayed for serum levels of mammary serum antigen (MSA) by an enzyme immunoassay (EIA) using the 3E1.2 monoclonal antibody. Using 300 IU as the arbitrary cut off to distinguish normal from abnormal individuals, 75% of patients with primary Stage I carcinoma of the breast (n = 1...

journal_title：British journal of cancer

authors： Stacker SA,Sacks NP,Golder J,Tjandra JJ,Thompson CH,Smithyman A,McKenzie IF

更新日期：1988-03-01 00:00:00

abstract：:The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a "severe" cellular reaction...

journal_title：British journal of cancer

authors： Elston CW,Bagshawe KD

更新日期：1973-09-01 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：:2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...

journal_title：British journal of cancer

authors： Jodrell DI,Bowman A,Rye R,Byrne B,Boddy A,Rafi I,Taylor GA,Johnston A,Clendeninn NJ

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Epstein-Barr virus-positive post-transplant lymphoproliferative disease (PTLD) is a potentially lethal complication of iatrogenic immunosupression after transplantation. Predicting the development of PTLD allowing early and effective intervention is therefore of importance. Polymorphisms within cytokine gene...

journal_title：British journal of cancer

authors： McAulay KA,Haque T,Crawford DH

更新日期：2009-09-15 00:00:00

abstract：:This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2-3). We evaluated 130 suitable women: 63 were screened biannually by Pap ...

journal_title：British journal of cancer

authors： Almog B,Gamzu R,Bornstein J,Levin I,Fainaru O,Niv J,Lessing JB,Bar-Am A

更新日期：2003-07-07 00:00:00

abstract：:Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 recepto...

journal_title：British journal of cancer

authors： Rivera E,Arrieta O,Guevara P,Duarte-Rojo A,Sotelo J

更新日期：2001-11-02 00:00:00

abstract：:Isomerisation to all-trans-retinoic acid (ATRA) is widely accepted as the key mechanism underlying the favourable clinical properties of 13-cis-retinoic acid (13cisRA). As intracellular metabolism of ATRA by CYP26 may result in clinical resistance to 13cisRA, an increase in efficacy may be achieved through modulation ...

journal_title：British journal of cancer

authors： Armstrong JL,Taylor GA,Thomas HD,Boddy AV,Redfern CP,Veal GJ

更新日期：2007-06-04 00:00:00

abstract：:Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-cont...

journal_title：British journal of cancer

authors： Fallowfield L,Gagnon D,Zagari M,Cella D,Bresnahan B,Littlewood TJ,McNulty P,Gorzegno G,Freund M,Epoetin Alfa Study Group.

更新日期：2002-12-02 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：:Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug...

journal_title：British journal of cancer

authors： Kerr DJ,Rustin GJ,Kaye SB,Selby P,Bleehen NM,Harper P,Brampton MH

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

journal_title：British journal of cancer

authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Testing for high-risk human papillomavirus (HPV) in primary screening for cervical cancer is considered more sensitive, but less specific, in comparison with Pap-smear cytology. Women with persistent HPV infections have a higher risk of developing cervical intraepithelial neoplasia 2+ (CIN2+) lesions. This s...

journal_title：British journal of cancer

authors： Gyllensten U,Sanner K,Gustavsson I,Lindell M,Wikström I,Wilander E

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...

journal_title：British journal of cancer

authors： Belin L,Tan A,De Rycke Y,Dechartres A

更新日期：2020-05-01 00:00:00

abstract：:The tolerability, anti-tumour activity and pharmacokinetic interaction of high-dose intravenous cyclosporin combined with intravenous etoposide was evaluated in children. Eighteen patients with recurrent or refractory tumours, all of whom had previously received etoposide, were treated with a combination of high-dose ...

journal_title：British journal of cancer

authors： Bisogno G,Cowie F,Boddy A,Thomas HD,Dick G,Pinkerton CR

更新日期：1998-06-01 00:00:00

abstract：:The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

journal_title：British journal of cancer

authors： Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

更新日期：1993-05-01 00:00:00

abstract：:An enzyme activity with the characteristics of reverse transcriptase was detected in marrow from patients with leukaemia in relapse and in firm haematological remission. The endogenous enzyme activities increased following culture, and in remission patients the enzyme activities reached levels equal to or exceeding th...

journal_title：British journal of cancer

authors： Mak TW,Aye MT,Messner H,Sheinin R,Till JE,McCulloch EA

更新日期：1974-06-01 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

journal_title：British journal of cancer

authors： Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

更新日期：2015-06-30 00:00:00

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00