Abstract：
BACKGROUND:Tumour heterogeneity is documented for many characters, including the production of growth factors, one of the hallmarks of cancer. What maintains heterogeneity remains an open question that has implications for diagnosis and treatment, as drugs that target growth factors are susceptible to the evolution of resistance. METHODS:I use evolutionary game theory to model collective interactions between cancer cells, to analyse the dynamics of the production of growth factors and the effect of therapies that reduce their amount. RESULTS:Five types of dynamics are possible, including the coexistence of producer and non-producer cells, depending on the production cost of the growth factor, on its diffusion range and on the degree of synergy of the benefit it confers to the cells. Perturbations of the equilibrium mimicking therapies that target growth factors are effective in reducing the amount of growth factor in the long term only if the reduction is extremely efficient and immediate. CONCLUSION:Collective interactions within the tumour can maintain heterogeneity for the production of growth factors and explain why therapies like anti-angiogenic drugs and RNA interference that reduce the amount of available growth factors are effective in the short term but often lead to relapse. Alternative strategies for evolutionarily stable treatments are discussed.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Archetti Mdoi
10.1038/bjc.2013.336subject
Has Abstractpub_date
2013-08-20 00:00:00pages
1056-62issue
4eissn
0007-0920issn
1532-1827pii
bjc2013336journal_volume
109pub_type
杂志文章abstract：:Large-scale genomic analyses of cutaneous melanoma have revealed insights into the aetiology and heterogeneity of this disease, as well as opportunities to further personalise treatment for patients with targeted and immune therapies. Herein, we review the proposed genomic classification of cutaneous melanoma from lar...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2016.195
更新日期：2016-07-12 00:00:00
abstract：:Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...
journal_title：British journal of cancer
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abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...
journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.170
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journal_title：British journal of cancer
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pub_type： 杂志文章
doi：10.1038/bjc.1974.98
更新日期：1974-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.62
更新日期：1986-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.40
更新日期：1977-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：2002-08-27 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6604539
更新日期：2008-08-19 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.29
更新日期：1996-01-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.255
更新日期：1985-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6603917
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pub_type： 杂志文章,评审
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.270
更新日期：2014-10-14 00:00:00
