Abstract:
:We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including the first report of an abnormal clone in LCH. The clone showed a t(7;12)(q11.2;p13) translocation and was detected in only a small percentage of cells. This case and a further three also contained non-clonal abnormalities and an increase in chromosome breakage. The fifth case, the only one in which no acquired abnormalities were seen, had a constitutional paracentric inversion of chromosome 13q.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Betts DR,Leibundgut KE,Feldges A,Plüss HJ,Niggli FKdoi
10.1038/bjc.1998.89subject
Has Abstractpub_date
1998-02-01 00:00:00pages
552-5issue
4eissn
0007-0920issn
1532-1827journal_volume
77pub_type
杂志文章abstract::Defects in the apoptotic system are likely to play a role in tumorigenesis. Pancreatic carcinoma cells are extremely resistant to apoptosis induction by chemotherapy suggesting that the apoptosis machinery is faulty. We investigated the integrity of the cytochrome c-dependent apoptotic apparatus in 10 human pancreatic...
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