Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.

abstract：BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...

journal_title：British journal of cancer

authors： Ko AH,Tempero MA,Shan YS,Su WC,Lin YL,Dito E,Ong A,Wang YW,Yeh CG,Chen LT

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer patients with luminal human epidermal growth factor receptor 2 (HER2)-negative tumours, as defined by immunohistochemistry, who received neo-adjuvant chemotherapy (N...

journal_title：British journal of cancer

authors： Horimoto Y,Arakawa A,Harada-Shoji N,Sonoue H,Yoshida Y,Himuro T,Igari F,Tokuda E,Mamat O,Tanabe M,Hino O,Saito M

更新日期：2015-01-20 00:00:00

abstract：:Germline anomalies of the INK4a-ARF and Cdk4 genes were sought in a series of 89 patients suspected of having a genetic predisposition to melanoma. Patients were selected based on the following criteria: (a) familial melanoma (23 cases), (b) multiple primary melanoma (MPM; 18 cases), (c) melanoma and additional unrela...

journal_title：British journal of cancer

authors： Soufir N,Lacapere JJ,Bertrand G,Matichard E,Meziani R,Mirebeau D,Descamps V,Gérard B,Archimbaud A,Ollivaud L,Bouscarat F,Baccard M,Lanternier G,Saïag P,Lebbé C,Basset-Seguin N,Crickx B,Cave H,Grandchamp B

更新日期：2004-01-26 00:00:00

abstract：BACKGROUND:The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS:We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adeno...

journal_title：British journal of cancer

authors： Strell C,Norberg KJ,Mezheyeuski A,Schnittert J,Kuninty PR,Moro CF,Paulsson J,Schultz NA,Calatayud D,Löhr JM,Frings O,Verbeke CS,Heuchel RL,Prakash J,Johansen JS,Östman A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

journal_title：British journal of cancer

authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

更新日期：2018-11-01 00:00:00

abstract：:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...

journal_title：British journal of cancer

authors： Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski T

更新日期：2002-06-17 00:00:00

abstract：:Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks...

journal_title：British journal of cancer

authors： Safi N,Anazodo A,Dickinson JE,Lui K,Wang AY,Li Z,Sullivan EA

更新日期：2019-10-01 00:00:00

abstract：:Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...

journal_title：British journal of cancer

authors： Vaage J,Harlos JP

更新日期：1991-05-01 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...

journal_title：British journal of cancer

authors： Edwards S,Lalor PF,Tuncer C,Adams DH

更新日期：2006-12-04 00:00:00

abstract：:The growth and spread of tumour cells depends on adequate vasculature. We have previously reported that the expression of interleukin-8 (IL-8) directly correlates with the vascularity of human gastric carcinomas. To provide evidence for a causal role of IL-8 in angiogenesis and tumorigenicity of human gastric cancer, ...

journal_title：British journal of cancer

authors： Kitadai Y,Takahashi Y,Haruma K,Naka K,Sumii K,Yokozaki H,Yasui W,Mukaida N,Ohmoto Y,Kajiyama G,Fidler IJ,Tahara E

更新日期：1999-10-01 00:00:00

abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

journal_title：British journal of cancer

authors： Martell RL,Slapak CA,Levy SB

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS:The rearranged genes were identified by breakpoint mapping, long-range PCR and sequencing. We investigated gene expression in...

journal_title：British journal of cancer

authors： Carter SA,Foster NA,Scarpini CG,Chattopadhyay A,Pett MR,Roberts I,Coleman N

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study...

journal_title：British journal of cancer

authors： Mandilaras V,Bouganim N,Yin H,Asselah J,Azoulay L

更新日期：2017-01-03 00:00:00

abstract：:The growth inhibitory effects of interferons, IFN-alpha and IFN-gamma on human lung cancer cell lines were studied using both a tetrazolium (MTT) colorimetric assay and direct cell counting. Significant discrepancies between the two assays were observed, the MTT assay consistently underestimating the growth inhibitory...

journal_title：British journal of cancer

authors： Jabbar SA,Twentyman PR,Watson JV

更新日期：1989-10-01 00:00:00

abstract：:The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...

journal_title：British journal of cancer

authors： Brown JS,Sundar R,Lopez J

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is highly resistant to chemotherapy because of a high apoptotic threshold. Recent evidences suggest that GSK-3beta positively regulates human pancreatic cancer and leukaemia cell survival in part through regulation of nuclear factor (NF-kappaB)-mediated expression of anti-apoptotic...

journal_title：British journal of cancer

authors： Bilim V,Ougolkov A,Yuuki K,Naito S,Kawazoe H,Muto A,Oya M,Billadeau D,Motoyama T,Tomita Y

更新日期：2009-12-15 00:00:00

abstract：:The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of doceta...

journal_title：British journal of cancer

authors： Clamp AR,Mäenpää J,Cruickshank D,Ledermann J,Wilkinson PM,Welch R,Chan S,Vasey P,Sorbe B,Hindley A,Jayson GC,Scottish Gynaecological Cancer Trials Group.

更新日期：2006-01-16 00:00:00

abstract：:Oesopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumours of the upper aero-digestive tract and the oesophagus. In this study, we compared cytological evaluation and molecular analysis for the detection of exfoliated cancer cells sampled with an OPB. A total of ...

journal_title：British journal of cancer

authors： Temam S,Trassard M,Leroux G,Bosq J,Luboinski B,Lenoir G,Bénard J,Janot F

更新日期：2003-06-02 00:00:00

abstract：:Manganese superoxide dismutase (SOD2) is an enzyme that catalyses the dismutation of superoxide in the mitochondria, leading to reduced levels of reactive oxygen species. Reduced expression levels of SOD2 have been shown to result in increased DNA damage and sod2 heterozygous mice have increased incidences of cancer. ...

journal_title：British journal of cancer

authors： Hurt EM,Thomas SB,Peng B,Farrar WL

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhag...

journal_title：British journal of cancer

authors： Piqueras M,Navarro S,Cañete A,Castel V,Noguera R

更新日期：2011-06-28 00:00:00

abstract：:Mutation and overexpression are the main activating mechanisms for the ras family of genes in human cancer and the variable tandem repeat (VTR) located at the 3' end of H-ras has been associated with this risk. In the present study, we have analysed the relative levels of expression of H-ras mRNA in 26 samples of squa...

journal_title：British journal of cancer

authors： Kiaris H,Spandidos DA,Jones AS,Vaughan ED,Field JK

更新日期：1995-07-01 00:00:00

abstract：:Trastuzumab is the only HER2/neu-directed therapy to have received Food and Drug Administration approval for the treatment of patients with metastatic breast cancer. The efficacy of trastuzumab depends on the HER2/neu status of the tumour and the patient's prior treatment, but even when patients are selected on the ba...

journal_title：British journal of cancer

authors： Fujita T,Doihara H,Kawasaki K,Takabatake D,Takahashi H,Washio K,Tsukuda K,Ogasawara Y,Shimizu N

更新日期：2006-01-30 00:00:00

abstract：BACKGROUND:Veliparib is a potent poly(ADP-ribose) polymerase inhibitor. This phase 1 study aimed to establish the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of veliparib combined with various FOLFIRI regimens in patients with solid tumours. METHODS:Patients received veliparib (10-270 mg BID, days...

journal_title：British journal of cancer

authors： Berlin J,Ramanathan RK,Strickler JH,Subramaniam DS,Marshall J,Kang YK,Hetman R,Dudley MW,Zeng J,Nickner C,Xiong H,Komarnitsky P,Shepherd SP,Hurwitz H,Lenz HJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express d...

journal_title：British journal of cancer

authors： Nitta T,Mitsuhashi T,Hatanaka Y,Miyamoto M,Oba K,Tsuchikawa T,Suzuki Y,Hatanaka KC,Hirano S,Matsuno Y

更新日期：2014-09-23 00:00:00

abstract：:We assessed incidence and mortality of colorectal cancer (CRC) at various ages among women and men in 38 European countries. The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening gui...

journal_title：British journal of cancer

authors： Brenner H,Hoffmeister M,Haug U

更新日期：2008-08-05 00:00:00

abstract：:Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...

journal_title：British journal of cancer

authors： MacDougall JR,Bani MR,Lin Y,Muschel RJ,Kerbel RS

更新日期：1999-05-01 00:00:00

abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...

journal_title：British journal of cancer

authors： Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

更新日期：1992-02-01 00:00:00

abstract：:The combination effect of docetaxel and capecitabine on tumour response rate and survival was demonstrated recently in metastatic breast cancer patients. This combination was based on an experimental hypothesis that taxane can increase tumour sensitivity to the effect of capecitabine through the upregulation of thymid...

journal_title：British journal of cancer

authors： Toi M,Bando H,Horiguchi S,Takada M,Kataoka A,Ueno T,Saji S,Muta M,Funata N,Ohno S

更新日期：2004-06-14 00:00:00