How to minimise the effect of tumour cell content in detection of aberrant genetic markers in neuroblastoma.

abstract：:Fluorescence polarization measurement during the progress of fluorochromasia has been used to study the response of human lymphocytes to phytohaemagglutinin (PHA) and to tumour-associated antigens, as a basis for the detection of malignant disease. Polarization (P) values of both stimulated and unstimulated lymphocyte...

journal_title：British journal of cancer

authors： Balding P,Light PA,Preece AW

更新日期：1980-01-01 00:00:00

abstract：:Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemo...

journal_title：British journal of cancer

authors： Hone P,Edwards A,Halls J,Cox R,Lloyd D

更新日期：2003-06-16 00:00:00

abstract：BACKGROUND:Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decrease...

journal_title：British journal of cancer

authors： Mull BB,Livingston JA,Patel N,Bui T,Hunt KK,Keyomarsi K

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:CD26 is a multifunctional membrane-bound glycoprotein that regulates tumour growth in addition to its other activities. Because disease aggressiveness is correlated with CD26 expression in several T-cell malignancies, we decided to investigate the invasiveness of cells expressing different levels of CD26. M...

journal_title：British journal of cancer

authors： Havre PA,Abe M,Urasaki Y,Ohnuma K,Morimoto C,Dang NH

更新日期：2009-09-15 00:00:00

abstract：:We followed 353 women referred with abnormal cervical cytology in a non-intervention cohort study. In 91 pregnant women we compared high-risk human papilloma virus rates in the subsequent trimesters and postpartum in comparison to 262 non-pregnant women. High-risk human papilloma virus clearance was compared with 179 ...

journal_title：British journal of cancer

authors： Nobbenhuis MA,Helmerhorst TJ,van den Brule AJ,Rozendaal L,Bezemer PD,Voorhorst FJ,Meijer CJ

更新日期：2002-07-01 00:00:00

abstract：:We assessed incidence and mortality of colorectal cancer (CRC) at various ages among women and men in 38 European countries. The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening gui...

journal_title：British journal of cancer

authors： Brenner H,Hoffmeister M,Haug U

更新日期：2008-08-05 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND:Cisplatin-radiotherapy is a preferred standard for locally advanced, head and neck squamous cell carcinoma (HNSCC). However, the cisplatin-attributable survival benefit is small and toxicity substantial. A biomarker of cisplatin resistance could guide treatment selection and spare morbidity. The ERCC1-XPF nu...

journal_title：British journal of cancer

authors： Bauman JE,Austin MC,Schmidt R,Kurland BF,Vaezi A,Hayes DN,Mendez E,Parvathaneni U,Chai X,Sampath S,Martins RG

更新日期：2013-10-15 00:00:00

abstract：BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...

journal_title：British journal of cancer

authors： Verkouteren BJA,Wakkee M,Reyners AKL,Nelemans P,Aarts MJB,Rácz E,Terra JB,Devriese LA,Alers RJ,Kapiteijn E,van Doorn R,Bekkenk MW,Reinders MGHC,Mosterd K

更新日期：2021-01-19 00:00:00

abstract：:Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from pa...

journal_title：British journal of cancer

authors： Mori N,Oka M,Hazama S,Iizuka N,Yamamoto K,Yoshino S,Tangoku A,Noma T,Hirose K

更新日期：2000-10-01 00:00:00

abstract：:A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...

journal_title：British journal of cancer

authors： Altieri A,Bosetti C,Talamini R,Gallus S,Franceschi S,Levi F,Dal Maso L,Negri E,La Vecchia C

更新日期：2002-11-18 00:00:00

abstract：:Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients with minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmaco...

journal_title：British journal of cancer

authors： Brada M,Judson I,Beale P,Moore S,Reidenberg P,Statkevich P,Dugan M,Batra V,Cutler D

更新日期：1999-11-01 00:00:00

abstract：:Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-us...

journal_title：British journal of cancer

authors： Jernström H,Frenander J,Fernö M,Olsson H

更新日期：1999-07-01 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon after Cisplatin-Bleomycin-Vinblastine combination chemotherapy, its relationship to polyneuropathy, and response to transcutaneous nerve stimulation (TNS), was studied in eight patients previously treated for testicular cancer. Peripheral circulation in the index finger was ...

journal_title：British journal of cancer

authors： Heier MS,Nilsen T,Graver V,Aass N,Fosså SD

更新日期：1991-04-01 00:00:00

abstract：:Evidence in the literature suggests that hyperthermia (HT) or inhibitors of calmodulin can increase the sensitivity of rodent cells to bleomycin (BLM) by interfering with DNA repair functions. In an attempt to explore methods of improving the efficacy of thermochemotherapy we have investigated the individual and combi...

journal_title：British journal of cancer

authors： Mircheva J,Smith PJ,Bleehen NM

更新日期：1986-01-01 00:00:00

abstract：:This article was originally published under a standard license to Publish, but has now been made available under a CC BY license. The PDF and HTML versions of the paper have been modified accordingly.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Evans TRJ,Kudo M,Finn RS,Han KH,Cheng AL,Ikeda M,Kraljevic S,Ren M,Dutcus CE,Piscaglia F,Sung MW

更新日期：2019-10-01 00:00:00

abstract：:Sublines of a human myeloid leukaemia cell line, KBM-3, with increasing degrees of resistance to the antileukaemic agent 4'-(9-acridinlylamino) methanesulphon-m-anisidide (m-AMSA) were evaluated for their response to this drug using a clonogenic assay to measure cell survival and alkaline elution to assess m-AMSA indu...

journal_title：British journal of cancer

authors： Skinner WL,Murray D,Kohli V,Beran M,McCredie KB,Freireich EJ,Andersson BS

更新日期：1990-01-01 00:00:00

abstract：:Laminin promotes the malignant phenotype, and the expression of certain laminin receptors is increased in malignancy. Previously, we demonstrated that a laminin-adhesive subclone of a human colon cancer cell line showed increased tumorigenicity in nude mice and increased affinity of the beta1 integrin for laminin rela...

journal_title：British journal of cancer

authors： Kim WH,Lee BL,Jun SH,Song SY,Kleinman HK

更新日期：1998-01-01 00:00:00

abstract：:The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...

journal_title：British journal of cancer

authors： Ford CE,Lau SK,Zhu CQ,Andersson T,Tsao MS,Vogel WF

更新日期：2007-03-12 00:00:00

abstract：:Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorect...

journal_title：British journal of cancer

authors： Akagi K,Ikeda Y,Miyazaki M,Abe T,Kinoshita J,Maehara Y,Sugimachi K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is highly resistant to chemotherapy because of a high apoptotic threshold. Recent evidences suggest that GSK-3beta positively regulates human pancreatic cancer and leukaemia cell survival in part through regulation of nuclear factor (NF-kappaB)-mediated expression of anti-apoptotic...

journal_title：British journal of cancer

authors： Bilim V,Ougolkov A,Yuuki K,Naito S,Kawazoe H,Muto A,Oya M,Billadeau D,Motoyama T,Tomita Y

更新日期：2009-12-15 00:00:00

abstract：:To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994-2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and o...

journal_title：British journal of cancer

authors： Ross PJ,Ashley S,Norton A,Priest K,Waters JS,Eisen T,Smith IE,O'Brien ME

更新日期：2004-05-17 00:00:00

abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...

journal_title：British journal of cancer

authors： Wang W,Chen H,Liu Z,Qu P,Lan J,Chen H,Zou L,Qiu J

更新日期：2016-02-02 00:00:00

abstract：:Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...

journal_title：British journal of cancer

authors： Symonds RP,Lord K,Mitchell AJ,Raghavan D

更新日期：2012-09-25 00:00:00

abstract：:Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significant...

journal_title：British journal of cancer

authors： Heuch JM,Heuch I,Kvåle G

更新日期：1996-10-01 00:00:00

abstract：:A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and -negative anal cancers. As part of a population-based case-control study in Denmark and Sweden, we interviewed 4...

journal_title：British journal of cancer

authors： Frisch M,Glimelius B,van den Brule AJ,Wohlfahrt J,Meijer CJ,Walboomers JM,Adami HO,Melbye M

更新日期：1998-12-01 00:00:00

abstract：:The effect of LiCl on melanoma cell growth and differentiation was studied in mouse and human melanoma cell lines. LiCl markedly inhibited B16 and HT-144 melanoma cell growth in vitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatment of B16 mouse melanoma cells with Li...

journal_title：British journal of cancer

authors： Nordenberg J,Panet C,Wasserman L,Malik Z,Fuchs A,Stenzel KH,Novogrodsky A

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rates using ovarian cancer as an example. METHODS:From the General Practi...

journal_title：British journal of cancer

authors： Tate AR,Nicholson A,Cassell JA

更新日期：2010-03-16 00:00:00

abstract：:Genomic alterations in the p53 tumour-suppressor gene and overexpression of p53 protein, resulting from gene mutations, are frequently found in pancreatic cancer. In this study we analysed the sera of 160 patients with malignant and benign pancreatic diseases for the presence of circulating antibodies to the p53 prote...

journal_title：British journal of cancer

authors： Marxsen J,Schmiegel W,Röder C,Harder R,Juhl H,Henne-Bruns D,Kremer B,Kalthoff H

更新日期：1994-11-01 00:00:00

abstract：:The orally administered tubulin-binding agent 1069C85 was developed with the hope of overcoming the multidrug resistance associated with existing anti-tubulin agents, such as the vinca alkaloids. A phase I study was performed using a single oral dose every 3 weeks, administered as a suspension reconstituted in 0.1% Tw...

journal_title：British journal of cancer

authors： Judson I,Briasoulis E,Raynaud F,Hanwell J,Berry C,Lacey H

更新日期：1997-01-01 00:00:00