Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues.


:Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorectal cancer patients was examined immunohistochemically. To verify VEGF-C mRNA expression, reverse transcriptase-polymerase chain reaction (RT-PCR) was carried out. The expression of VEGF-C correlated with lymphatic involvement, lymph nodes metastasis, and depth of invasion. On the other hand, correlations were nil with regard to gender of the patients, histologic type, venous involvement, and liver metastasis. The expression of VEGF-C in metastatic lymph nodes was fairly consistent with this expression in the primary tumour. Survival time was shorter for VEGF-C positive groups than for VEGF-C negative ones, but with no statistically significant difference. RT-PCR findings revealed that the expression of VEGF-C mRNA correlated mostly with that of VEGF-C protein expression. VEGF-C may play an important role in lymphatic spread of colorectal cancer.


Br J Cancer


Akagi K,Ikeda Y,Miyazaki M,Abe T,Kinoshita J,Maehara Y,Sugimachi K




Has Abstract


2000-10-01 00:00:00














  • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment.

    abstract::Flunarizine is a class IV calcium channel blocker which increases oxygen delivery to hypoxic regions in solid tumours, exerting a radiosensitising effect in vivo in animal tumour models. Precisely how the drug improves oxygenation is not well understood. We hypothesised that metabolic conditions present within solid t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kavanagh BD,Coffey BE,Needham D,Hochmuth RM,Dewhirst MW

    更新日期:1993-04-01 00:00:00

  • Phase II study of docetaxel in patients with metastatic pancreatic cancer: a Japanese cooperative study. Cooperative Group of Docetaxel for Pancreatic Cancer in Japan.

    abstract::Docetaxel has been reported to show promising anti-tumour activity in pancreatic ductal cancer (PC). This study was conducted to evaluate the activity and toxicity of moderate-dose (60 mg m(-2)) docetaxel in Japanese chemo-naive patients with measurable metastatic PC. The patients had a performance status of 0-2. They...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Okada S,Sakata Y,Matsuno S,Kurihara M,Sasaki Y,Ohashi Y,Taguchi T

    更新日期:1999-05-01 00:00:00

  • Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation.

    abstract::Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the DNA-PK complex, i.e....

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Vaganay-Juéry S,Muller C,Marangoni E,Abdulkarim B,Deutsch E,Lambin P,Calsou P,Eschwege F,Salles B,Joiner M,Bourhis J

    更新日期:2000-08-01 00:00:00

  • The inhibition of arginase by proline in cell-free extracts of mouse mammary tumour.

    abstract::Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rao KV,Pai SR,Bapat CV

    更新日期:1974-08-01 00:00:00

  • Clinical value of R-spondins in triple-negative and metaplastic breast cancers.

    abstract:BACKGROUND:RSPO ligands, activators of the Wnt/β-catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). METHODS:Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT-PCR. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Coussy F,Lallemand F,Vacher S,Schnitzler A,Chemlali W,Caly M,Nicolas A,Richon S,Meseure D,El Botty R,De-Plater L,Fuhrmann L,Dubois T,Roman-Roman S,Dangles-Marie V,Marangoni E,Bièche I

    更新日期:2017-06-06 00:00:00

  • A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer.

    abstract::The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

    更新日期:2006-03-27 00:00:00

  • SCOTROC 2B: feasibility of carboplatin followed by docetaxel or docetaxel-irinotecan as first-line therapy for ovarian cancer.

    abstract::The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of doceta...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Clamp AR,Mäenpää J,Cruickshank D,Ledermann J,Wilkinson PM,Welch R,Chan S,Vasey P,Sorbe B,Hindley A,Jayson GC,Scottish Gynaecological Cancer Trials Group.

    更新日期:2006-01-16 00:00:00

  • Changes in psychological distress after cancer genetic counselling: a comparison of affected and unaffected women.

    abstract::This study sought to examine changes in psychological distress following cancer genetic counselling. Women attending a family cancer clinic completed questionnaires before their appointment and at 2 weeks, 6 months and 12 months after their appointment. Twenty-six women were at low risk of developing breast or ovarian...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bish A,Sutton S,Jacobs C,Levene S,Ramirez A,Hodgson S

    更新日期:2002-01-07 00:00:00

  • Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer.

    abstract::Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cance...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ryan B,O'Donovan N,Browne B,O'Shea C,Crown J,Hill AD,McDermott E,O'Higgins N,Duffy MJ

    更新日期:2005-01-17 00:00:00

  • Salt intake and gastric cancer risk according to Helicobacter pylori infection, smoking, tumour site and histological type.

    abstract:BACKGROUND:Although salt intake is considered a probable risk factor for gastric cancer, relevant studies have provided heterogeneous results, and the magnitude of the association has not been accurately quantified. METHODS:To quantify gastric cancer risk in relation to dietary salt exposure according to Helicobacter ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Peleteiro B,Lopes C,Figueiredo C,Lunet N

    更新日期:2011-01-04 00:00:00

  • Mitomycin C, vinblastine and cis-platin. An active regimen for advanced non-small cell lung cancer.

    abstract::Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

    更新日期:1987-10-01 00:00:00

  • Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer.

    abstract:BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Greystoke A,Dean E,Saunders MP,Cummings J,Hughes A,Ranson M,Dive C,Renehan AG

    更新日期:2012-10-23 00:00:00

  • Avascular and vascular phases of tumour growth in the chick embryo.

    abstract::The chick embryo was used to study the relationship between the onset of tumour neovascularization and tumour growth. Walker 256 carcinosarcoma was implanted on the chrioallantoic membrane (CAM) of about 600 embryos aged 5-16 days. Tumour diameter and changes in the CAM vasculature in response to the implants were rec...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Knighton D,Ausprunk D,Tapper D,Folkman J

    更新日期:1977-03-01 00:00:00

  • Doppler assessment of the uterine circulation and the clinical behaviour of gestational trophoblastic tumours requiring chemotherapy.

    abstract::The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Long MG,Boultbee JE,Langley R,Newlands ES,Begent RH,Bagshawe KD

    更新日期:1992-11-01 00:00:00

  • Pharmacokinetics and binding of the bioreductive probe for hypoxia, NITP: effect of route of administration.

    abstract::The novel compound 7(-)[4'-(2-nitroimidazol-l-yl)-butyl]-theophylline (NITP) can be used as an immunologically detectable probe for hypoxic cells. Because of the limited water solubility of NITP, it has been administered dissolved in peanut oil with 10% dimethylsulphoxide (DMSO). A new aqueous formulation has been dev...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hodgkiss RJ,Stratford MR,Dennis MF,Hill SA

    更新日期:1995-12-01 00:00:00

  • 'Proteolytic switching': opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression.

    abstract::Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: MacDougall JR,Bani MR,Lin Y,Muschel RJ,Kerbel RS

    更新日期:1999-05-01 00:00:00

  • Changes in expression of cellular oncogenes and endogenous retrovirus-like sequences during hepatocarcinogenesis induced by a peroxisome proliferator.

    abstract::Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hsieh LL,Shinozuka H,Weinstein IB

    更新日期:1991-11-01 00:00:00

  • Breast cancer risk among first-generation migrants in the Netherlands.

    abstract::We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Visser O,van der Kooy K,van Peppen AM,Ory FG,van Leeuwen FE

    更新日期:2004-06-01 00:00:00

  • Cells bearing Fc receptors in human malignant solid tumours.

    abstract::Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells i...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Svennevig JL,Andersson TR

    更新日期:1982-02-01 00:00:00

  • RNA-tumour-virus genes and transforming genes: patterns of transmission.

    abstract::RNA tumour virus genes are contained in the chromosomal DNA of most vertebrates, and may be transmitted vertically from parent to progeny along with other cellular genes, as well as horizontally as infectious particles. Activation of these viral genes may be part of the means by which RNA tumour viruses produce cancer...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Todaro GJ

    更新日期:1978-02-01 00:00:00

  • Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response.

    abstract::Recent studies have suggested a correlation between the rate and incidence of apoptosis and the radiation response of particular cell lines. However, we found that increasing the rate of induction of apoptosis in the fibroblast line 208F, by transfecting it with human c-myc, did not lead to a change in its clonogenic ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Aldridge DR,Arends MJ,Radford IR

    更新日期:1995-03-01 00:00:00

  • Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma.

    abstract:BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Goeppert B,Roessler S,Renner M,Singer S,Mehrabi A,Vogel MN,Pathil A,Czink E,Köhler B,Springfeld C,Pfeiffenberger J,Rupp C,Weiss KH,Schirmacher P,von Knebel Doeberitz M,Kloor M

    更新日期:2019-01-01 00:00:00

  • Two types of soft tissue sarcoma of uncertain histogenesis.

    abstract::A brief account is given of two types of rare soft tissue sarcoma of uncertain histogenesis. The danger of mistaking the epitheloid sarcoma for a benign lesion is emphasized. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Mackenzie DH

    更新日期:1971-09-01 00:00:00

  • KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.

    abstract:BACKGROUND:Pancreatic cancer is highly malignant and characterised by rapid and uncontrolled growth. While some of the important regulatory networks involved in pancreatic cancer have been determined, the cancer relevant genes have not been fully identified. METHODS:We screened genes that may control proliferation in ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wang J,Guo X,Xie C,Jiang J

    更新日期:2017-07-11 00:00:00

  • Early toxicity predicts long-term survival in high-grade glioma.

    abstract:BACKGROUND:Patients with high-grade gliomas are treated with surgery followed by chemoradiation. The risk factors and implications of neurological side effects are not known. METHODS:Acute and late ≥ grade 3 neurological toxicities (NTs) were analysed among 2761 patients from 14 RTOG trials accrued from 1983 to 2003. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lawrence YR,Wang M,Dicker AP,Andrews D,Curran WJ Jr,Michalski JM,Souhami L,Yung WK,Mehta M

    更新日期:2011-04-26 00:00:00

  • The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo.

    abstract::The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Grau C,Khalil AA,Nordsmark M,Horsman MR,Overgaard J

    更新日期:1994-01-01 00:00:00

  • Phase Ib study of CP-868,596, a PDGFR inhibitor, combined with docetaxel with or without axitinib, a VEGFR inhibitor.

    abstract:BACKGROUND:Tumoural interstitial hypertension, possibly modulated by platelet-derived and vascular endothelial growth factor receptors (PDGFR and VEGFR), may mediate resistance to chemotherapy. METHODS:Forty-eight patients with advanced solid tumours received oral PDGFR inhibitor CP-868,596 (60-100 mg twice daily (BID...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Michael M,Vlahovic G,Khamly K,Pierce KJ,Guo F,Olszanski AJ

    更新日期:2010-11-09 00:00:00

  • Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes.

    abstract::Besides cytotoxicity, taxanes induce other biological effects, especially in the immune system. Taxanes have demonstrated immunostimulatory effects against neoplasms, supporting the idea that these agents suppress cancer through several mechanisms and not solely through inhibiting cell division. The purpose of the pre...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tsavaris N,Kosmas C,Vadiaka M,Kanelopoulos P,Boulamatsis D

    更新日期:2002-07-01 00:00:00

  • Molecular analysis of local relapse in high-risk breast cancer patients: can radiotherapy fractionation and time factors make a difference?

    abstract::Large primary breast tumours and extensive lymph node involvement are linked to a high rate of local recurrence after surgery. In 10-20% of such high-risk breast cancer patients, local relapse will occur despite postoperative radiotherapy. In the present study, we investigated whether molecular features, such as angio...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Koukourakis MI,Giatromanolaki A,Galazios G,Sivridis E

    更新日期:2003-03-10 00:00:00

  • Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.

    abstract::The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ford CE,Lau SK,Zhu CQ,Andersson T,Tsao MS,Vogel WF

    更新日期:2007-03-12 00:00:00