听力与言语-语言病理学

行为科学

医学伦理学

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  • First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients: a propensity-matched survival analysis.

    abstract:BACKGROUND:Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line an...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01229-1

    authors: van Breeschoten J,Wouters MWJM,Hilarius DL,Haanen JB,Blank CU,Aarts MJB,van den Berkmortel FWPJ,de Groot JB,Hospers GAP,Kapiteijn E,Piersma D,van Rijn RS,Suijkerbuijk KPM,Blokx WAM,Tije BJT,Veldt AAMV,Vreugdenhil A,Boer

    更新日期:2021-01-26 00:00:00

  • Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases.

    abstract:BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01254-0

    authors: Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

    更新日期:2021-01-21 00:00:00

  • Eight years of experience with vismodegib for advanced and multiple basal cell carcinoma patients in the Netherlands: a retrospective cohort study.

    abstract:BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01220-w

    authors: Verkouteren BJA,Wakkee M,Reyners AKL,Nelemans P,Aarts MJB,Rácz E,Terra JB,Devriese LA,Alers RJ,Kapiteijn E,van Doorn R,Bekkenk MW,Reinders MGHC,Mosterd K

    更新日期:2021-01-19 00:00:00

  • Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial).

    abstract:BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01222-8

    authors: Ueno H,Ishiguro M,Nakatani E,Ishikawa T,Uetake H,Murotani K,Matsui S,Teramukai S,Sugai T,Ajioka Y,Maruo H,Kotaka M,Tsujie M,Munemoto Y,Yamaguchi T,Kuroda H,Fukunaga M,Tomita N,Sugihara K

    更新日期:2021-01-07 00:00:00

  • Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer.

    abstract::Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue of the British Journal of Cancer provide in vivo evidence that the degree to which various breast cancer cell lines acidify their e...

    journal_title:British journal of cancer

    pub_type: 社论

    doi:10.1038/s41416-020-01171-2

    authors: Rolver MG,Pedersen SF

    更新日期:2021-01-01 00:00:00

  • Emerging immunotherapies for metastasis.

    abstract::Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and a...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/s41416-020-01160-5

    authors: Edwards SC,Hoevenaar WHM,Coffelt SB

    更新日期:2021-01-01 00:00:00

  • Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.

    abstract:BACKGROUND:Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT t...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01095-x

    authors: Siddiqui MA,Gollavilli PN,Ramesh V,Parma B,Schwab A,Vazakidou ME,Natesan R,Saatci O,Rapa I,Bironzo P,Schuhwerk H,Asangani IA,Sahin O,Volante M,Ceppi P

    更新日期:2021-01-01 00:00:00

  • Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project.

    abstract:BACKGROUND:Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes fr...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01181-0

    authors: Millen GC,Arnold R,Cazier JB,Curley H,Feltbower RG,Gamble A,Glaser AW,Grundy RG,Lee LYW,McCabe MG,Phillips RS,Stiller CA,Várnai C,Kearns PR

    更新日期:2020-12-10 00:00:00

  • The current treatment landscape in the UK for stage III NSCLC.

    abstract::For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/s41416-020-01069-z

    authors: Evison M,AstraZeneca UK Limited.

    更新日期:2020-12-01 00:00:00

  • Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.

    abstract:BACKGROUND:Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, many additional genetic ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01084-0

    authors: Zhou Y,Dagli Hernandez C,Lauschke VM

    更新日期:2020-12-01 00:00:00

  • Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.

    abstract::Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01105-y

    authors: Mout L,Moll JM,Chen M,de Morrée ES,de Ridder CMA,Gibson A,Stuurman D,Aghai A,Erkens-Schulze S,Mathijssen RHJ,Sparreboom A,de Wit R,Lolkema MP,van Weerden WM

    更新日期:2020-12-01 00:00:00

  • The COVID-19 pandemic and impact on breast cancer diagnoses: what happened in England in the first half of 2020.

    abstract::Delays in cancer diagnosis and treatment due to the COVID-19 pandemic is a widespread source of concern, but the scale of the challenge for different tumour sites is not known. Routinely collected NHS England Cancer Waiting Time data were analysed to compare activity for breast cancer in the first 6 months of 2020 com...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01182-z

    authors: Gathani T,Clayton G,MacInnes E,Horgan K

    更新日期:2020-11-30 00:00:00

  • A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours.

    abstract:BACKGROUND:This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/t...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01151-6

    authors: van Bussel MTJ,Awada A,de Jonge MJA,Mau-Sørensen M,Nielsen D,Schöffski P,Verheul HMW,Sarholz B,Berghoff K,El Bawab S,Kuipers M,Damstrup L,Diaz-Padilla I,Schellens JHM

    更新日期:2020-11-24 00:00:00

  • Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project.

    abstract:BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01152-5

    authors: Shaaban AM,Hilton B,Clements K,Provenzano E,Cheung S,Wallis MG,Sawyer E,Thomas JS,Hanby AM,Pinder SE,Thompson AM,Sloane Project Steering Committee.

    更新日期:2020-11-17 00:00:00

  • FOLFIRI plus cetuximab or bevacizumab for advanced colorectal cancer: final survival and per-protocol analysis of FIRE-3, a randomised clinical trial.

    abstract:BACKGROUND:Cetuximab plus FOLFIRI improved overall survival compared with bevacizumab plus FOLFIRI in KRAS wild-type metastatic colorectal cancer (mCRC) in FIRE-3, but no corresponding benefit was found for progression-free survival. This analysis aimed to determine whether cetuximab improves response and survival vers...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01140-9

    authors: Heinemann V,von Weikersthal LF,Decker T,Kiani A,Kaiser F,Al-Batran SE,Heintges T,Lerchenmüller C,Kahl C,Seipelt G,Kullmann F,Moehler M,Scheithauer W,Held S,Miller-Phillips L,Modest DP,Jung A,Kirchner T,Stintzing S

    更新日期:2020-11-06 00:00:00

  • Chemoradiotherapy with extended nodal irradiation and/or erlotinib in locally advanced oesophageal squamous cell cancer: long-term update of a randomised phase 3 trial.

    abstract:BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01054-6

    authors: Xie C,Jing Z,Luo H,Jiang W,Ma L,Hu W,Zheng A,Li D,Ding L,Zhang H,Xie C,Lian X,Du D,Chen M,Bian X,Tan B,Xia B,Xie R,Liu Q,Wang L,Wu S

    更新日期:2020-11-01 00:00:00

  • Vascular aging in long-term survivors of testicular cancer more than 20 years after treatment with cisplatin-based chemotherapy.

    abstract:BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01049-3

    authors: Stelwagen J,Lubberts S,Steggink LC,Steursma G,Kruyt LM,Donkerbroek JW,van Roon AM,van Gessel AI,van de Zande SC,Meijer C,Gräfin Zu Eulenburg CH,Oosting SF,Nuver J,Walenkamp AME,Jan de Jong I,Lefrandt JD,Gietema JA

    更新日期:2020-11-01 00:00:00

  • Platelets enhance malignant behaviours of gastric cancer cells via direct contacts.

    abstract::In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01134-7

    authors: Saito R,Shoda K,Maruyama S,Yamamoto A,Takiguchi K,Furuya S,Hosomura N,Akaike H,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Suzuki-Inoue K,Ichikawa D

    更新日期:2020-10-28 00:00:00

  • Prognostic significance of pre-treatment neutrophil-to-lymphocyte ratio (NLR) in patients with oropharyngeal cancer treated with radiotherapy.

    abstract:BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01106-x

    authors: Ng SP,Bahig H,Jethanandani A,Sturgis EM,Johnson FM,Elgohari B,Gunn GB,Ferrarotto R,Phan J,Rosenthal DI,Frank SJ,Fuller CD,Garden AS

    更新日期:2020-10-14 00:00:00

  • Association between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response after neoadjuvant chemoradiotherapy and resection.

    abstract:BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0989-1

    authors: He F,Ju HQ,Ding Y,Jiang Z,Li Z,Huang B,Wang X,Zhao Y,Li Y,Qi B,Luo W,Zhang Z,Pei Q,Chen H,Liu S,Pang X,Zheng J,Wang J,Ajani JA,Wan XB

    更新日期:2020-10-01 00:00:00

  • Whole-exome sequencing of long-term, never relapse exceptional responders of trastuzumab-treated HER2+ metastatic breast cancer.

    abstract::Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberration...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0999-z

    authors: Walsh N,Andrieu C,O'Donovan P,Quinn C,Maguire A,Furney SJ,Gullo G,Crown J

    更新日期:2020-10-01 00:00:00

  • Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer - translational results from the AIO-PK0104 Phase 3 study.

    abstract:BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01029-7

    authors: Guenther M,Haas M,Heinemann V,Kruger S,Westphalen CB,von Bergwelt-Baildon M,Mayerle J,Werner J,Kirchner T,Boeck S,Ormanns S

    更新日期:2020-10-01 00:00:00

  • Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma.

    abstract:BACKGROUND:Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker. METHODS:Forty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by tar...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-1002-8

    authors: Openshaw MR,Mohamed AA,Ottolini B,Fernandez-Garcia D,Richards CJ,Page K,Guttery DS,Thomas AL,Shaw JA

    更新日期:2020-10-01 00:00:00

  • Evaluation of p16INK4a expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation.

    abstract:BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0964-x

    authors: Wagner S,Prigge ES,Wuerdemann N,Reder H,Bushnak A,Sharma SJ,Obermueller T,von Knebel Doeberitz M,Dreyer T,Gattenlöhner S,Wolf G,Pons-Kühnemann J,Wittekindt C,Klussmann JP

    更新日期:2020-09-01 00:00:00

  • Examining treatment responses of diagnostic marrow in murine xenografts to predict relapse in children with acute lymphoblastic leukaemia.

    abstract:BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0933-4

    authors: Alruwetei AM,Bendak K,Yadav BD,Carol H,Evans K,Mayoh C,Sutton R,Marshall GM,Lock RB

    更新日期:2020-09-01 00:00:00

  • Seropositivity for Helicobacter pylori and hepatobiliary cancers in the PLCO study.

    abstract::Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0961-0

    authors: Makkar R,Butt J,Huang WY,McGlynn KA,Koshiol J,Pawlita M,Waterboer T,Freedman ND,Murphy G

    更新日期:2020-09-01 00:00:00

  • Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events.

    abstract::With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to o...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/s41416-020-0949-9

    authors: Grünwald V,Voss MH,Rini BI,Powles T,Albiges L,Giles RH,Jonasch E

    更新日期:2020-09-01 00:00:00

  • Machine learning-based lifetime breast cancer risk reclassification compared with the BOADICEA model: impact on screening recommendations.

    abstract:BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0937-0

    authors: Ming C,Viassolo V,Probst-Hensch N,Dinov ID,Chappuis PO,Katapodi MC

    更新日期:2020-09-01 00:00:00

  • Neoadjuvant modified FOLFIRINOX followed by postoperative gemcitabine in borderline resectable pancreatic adenocarcinoma: a Phase 2 study for clinical and biomarker analysis.

    abstract:BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0867-x

    authors: Yoo C,Lee SS,Song KB,Jeong JH,Hyung J,Park DH,Song TJ,Seo DW,Lee SK,Kim MH,Lee SS,Kim JH,Jin HS,Park JH,Hwang DW,Lee JH,Lee W,Chang HM,Kim KP,Ryoo BY,Kim SC

    更新日期:2020-08-01 00:00:00

  • Association between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality.

    abstract:BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0883-x

    authors: Kim JH,Han KD,Lee JK,Kim HS,Cha JM,Park S,Kim JS,Kim WH,Big Data Research Group (BDRG) of the Korean Society of Gastroenterology (KSG).

    更新日期:2020-08-01 00:00:00

  • First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor.

    abstract:BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0916-5

    authors: Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

    更新日期:2020-08-01 00:00:00

  • BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene.

    abstract:BACKGROUND:Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription. BRD4 has been implicated in cell proliferation, metast...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0907-6

    authors: Yamamoto T,Hirosue A,Nakamoto M,Yoshida R,Sakata J,Matsuoka Y,Kawahara K,Nagao Y,Nagata M,Takahashi N,Hiraki A,Shinohara M,Nakao M,Saitoh N,Nakayama H

    更新日期:2020-08-01 00:00:00

  • Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study.

    abstract:BACKGROUND:The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. METHODS:Canc...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0869-8

    authors: Welch CA,Sweeting MJ,Lambert PC,Rutherford MJ,Jack RH,West D,Adlam D,Peake M

    更新日期:2020-08-01 00:00:00

  • The myth of pulmonary metastasectomy.

    abstract::Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0927-2

    authors: Macbeth F,Fallowfield L

    更新日期:2020-08-01 00:00:00

  • The association of diabetes with risk of prostate cancer defined by clinical and molecular features.

    abstract:BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0910-y

    authors: Feng X,Song M,Preston MA,Ma W,Hu Y,Pernar CH,Stopsack KH,Ebot EM,Fu BC,Zhang Y,Li N,Dai M,Liu L,Giovannucci EL,Mucci LA

    更新日期:2020-08-01 00:00:00

  • Correction: Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误

    doi:10.1038/s41416-020-0879-6

    authors: Gao M,Lin M,Moffitt RA,Salazar MA,Park J,Vacirca J,Huang C,Shroyer KR,Choi M,Georgakis GV,Sasson AR,Talamini MA,Kim J

    更新日期:2020-08-01 00:00:00

  • Lessons to Europe from China for cancer treatment during the COVID-19 pandemic.

    abstract::During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0856-0

    authors: Peng L,Yang JS,Stebbing J

    更新日期:2020-07-01 00:00:00

  • Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC.

    abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0892-9

    authors: Rong C,Muller MF,Xiang F,Jensen A,Weichert W,Major G,Plinkert PK,Hess J,Affolter A

    更新日期:2020-07-01 00:00:00

  • Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection.

    abstract:BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0864-0

    authors: Liu WR,Tian MX,Tang Z,Fang Y,Zhou YF,Song SS,Jiang XF,Wang H,Tao CY,Zhou PY,Qu WF,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH

    更新日期:2020-07-01 00:00:00

  • KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression.

    abstract:BACKGROUND:Kaposi's Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly infiltrate Kaposi's sarc...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0872-0

    authors: Gilardini Montani MS,Falcinelli L,Santarelli R,Granato M,Romeo MA,Cecere N,Gonnella R,D'Orazi G,Faggioni A,Cirone M

    更新日期:2020-07-01 00:00:00

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