解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01229-1
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01254-0
更新日期:2021-01-21 00:00:00
abstract:BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01220-w
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01222-8
更新日期:2021-01-07 00:00:00
abstract::Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue of the British Journal of Cancer provide in vivo evidence that the degree to which various breast cancer cell lines acidify their e...
journal_title:British journal of cancer
pub_type: 社论
doi:10.1038/s41416-020-01171-2
更新日期:2021-01-01 00:00:00
abstract::Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and a...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-020-01160-5
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01095-x
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes fr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01181-0
更新日期:2020-12-10 00:00:00
abstract::For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-020-01069-z
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, many additional genetic ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01084-0
更新日期:2020-12-01 00:00:00
abstract::Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01105-y
更新日期:2020-12-01 00:00:00
abstract::Delays in cancer diagnosis and treatment due to the COVID-19 pandemic is a widespread source of concern, but the scale of the challenge for different tumour sites is not known. Routinely collected NHS England Cancer Waiting Time data were analysed to compare activity for breast cancer in the first 6 months of 2020 com...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01182-z
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01151-6
更新日期:2020-11-24 00:00:00
abstract:BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01152-5
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:Cetuximab plus FOLFIRI improved overall survival compared with bevacizumab plus FOLFIRI in KRAS wild-type metastatic colorectal cancer (mCRC) in FIRE-3, but no corresponding benefit was found for progression-free survival. This analysis aimed to determine whether cetuximab improves response and survival vers...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01140-9
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01054-6
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01049-3
更新日期:2020-11-01 00:00:00
abstract::In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01134-7
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01106-x
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0989-1
更新日期:2020-10-01 00:00:00
abstract::Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberration...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0999-z
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01029-7
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker. METHODS:Forty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by tar...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-1002-8
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0964-x
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0933-4
更新日期:2020-09-01 00:00:00
abstract::Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0961-0
更新日期:2020-09-01 00:00:00
abstract::With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to o...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-020-0949-9
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0937-0
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0867-x
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0883-x
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0916-5
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription. BRD4 has been implicated in cell proliferation, metast...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0907-6
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. METHODS:Canc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0869-8
更新日期:2020-08-01 00:00:00
abstract::Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0927-2
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0910-y
更新日期:2020-08-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:British journal of cancer
pub_type: 已发布勘误
doi:10.1038/s41416-020-0879-6
更新日期:2020-08-01 00:00:00
abstract::During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0856-0
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0892-9
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0864-0
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Kaposi's Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly infiltrate Kaposi's sarc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0872-0
更新日期:2020-07-01 00:00:00