Birth characteristics and risk of Wilms' tumour: a nationwide prospective study in Norway.

abstract：BACKGROUND:Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS:The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 partic...

journal_title：British journal of cancer

authors： Pang Y,Kartsonaki C,Guo Y,Chen Y,Yang L,Bian Z,Bragg F,Millwood IY,Mao E,Li Y,Shi L,Chen J,Li L,Holmes MV,Chen Z

更新日期：2018-07-01 00:00:00

abstract：:The aim of this study was to determine the dose-limiting toxicity (DLT) and establish the recommended dose for mitomycin C added every 3 weeks to the standard combination dose of capecitabine. Cohorts of at least three patients with pretreated gastrointestinal carcinoma received capecitabine 1000 mg m(-2) orally twice...

journal_title：British journal of cancer

authors： Hofheinz RD,Hartmann JT,Willer A,Oechsle K,Hartung G,Gnad U,Saussele S,Kreil S,Bokemeyer C,Hehlmann R,Hochhaus A

更新日期：2004-08-31 00:00:00

abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...

journal_title：British journal of cancer

authors： Rand V,Prebble E,Ridley L,Howard M,Wei W,Brundler MA,Fee BE,Riggins GJ,Coyle B,Grundy RG,Children's Cancer and Leukaemia Group Biological Studies Committee.

更新日期：2008-10-07 00:00:00

abstract：:This study evaluates the efficacy of capecitabine using data from a large, well-characterised population of patients with metastatic colorectal cancer (mCRC) treated in two identically designed phase III studies. A total of 1207 patients with previously untreated mCRC were randomised to either oral capecitabine (1250 ...

journal_title：British journal of cancer

authors： Van Cutsem E,Hoff PM,Harper P,Bukowski RM,Cunningham D,Dufour P,Graeven U,Lokich J,Madajewicz S,Maroun JA,Marshall JL,Mitchell EP,Perez-Manga G,Rougier P,Schmiegel W,Schoelmerich J,Sobrero A,Schilsky RL

更新日期：2004-03-22 00:00:00

abstract：BACKGROUND:Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by binding neuropilin-1 (NRP1)...

journal_title：British journal of cancer

authors： Akashi Y,Oda T,Ohara Y,Miyamoto R,Kurokawa T,Hashimoto S,Enomoto T,Yamada K,Satake M,Ohkohchi N

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear. METHODS:Immunohis...

journal_title：British journal of cancer

authors： Li N,Kong J,Lin Z,Yang Y,Jin T,Xu M,Sun J,Chen L

更新日期：2019-04-01 00:00:00

abstract：:In the district of Srikakulam in Andhra Pradesh in South India the habit of reverse smoking is widespread. In a house to house survey of oral cancer and precancerous conditions, comprising 10,169 villagers, 43·8% were reverse smokers; the female: male ratio being 1·7: 1. Ten previously undiagnosed cases of oral cancer...

journal_title：British journal of cancer

authors： Pindborg JJ,Mehta FS,Gupta PC,Daftary DK,Smith CJ

更新日期：1971-03-01 00:00:00

abstract：:Over the period 1966-1995, based on 11,662 patients, the incidence of squamous cell carcinoma of the skin increased three to four times in Norway mainly as a result of an increased number of localized tumours. In men, cancer of the auricle was the second most common site; in women the incidence was low. ...

journal_title：British journal of cancer

authors： Iversen T,Tretli S

更新日期：1999-10-01 00:00:00

abstract：:Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the ...

journal_title：British journal of cancer

authors： Gothoskar SV,Talwalkar GV,Bhide SV

更新日期：1970-09-01 00:00:00

abstract：:Three biochemical markers of collagen metabolism were measured in 39 osteosarcoma patients. The pretreatment values did not predict outcome, and the markers showed no consistent change upon development of metastases. Both the age of the patients and the multimodality therapy affected the collagen metabolites. These fi...

journal_title：British journal of cancer

authors： Wiklund T,Blomqvist C,Risteli L,Risteli J,Karaharju E,Elomaa I

更新日期：1996-01-01 00:00:00

abstract：:To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...

journal_title：British journal of cancer

authors： Panahy C,Puddefoot JR,Anderson E,Vinson GP,Berry CL,Turner MJ,Brown CL,Goode AW

更新日期：1987-04-01 00:00:00

abstract：:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...

journal_title：British journal of cancer

authors： Dowsett M,Shearer RJ,Ponder BA,Malone P,Jeffcoate SL

更新日期：1988-02-01 00:00:00

abstract：:Imatinib mesilate (Glivec), Novartis Pharmaceuticals) is a novel therapy for the treatment of chronic myeloid leukaemia (CML). We evaluated the cost-effectiveness of imatinib (600 mg daily) when used for the treatment of patients in advanced stages of CML (accelerated phase and blast crisis) against conventional thera...

journal_title：British journal of cancer

authors： Gordois A,Scuffham P,Warren E,Ward S

更新日期：2003-08-18 00:00:00

abstract：:A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...

journal_title：British journal of cancer

authors： Oza AM,Ganesan TS,Dorreen M,Johnson PW,Waxman J,Gregory W,Lim J,Wright J,Dadiotis L,Barbounis V

更新日期：1992-03-01 00:00:00

abstract：:During the period 1943-1980 a significant increase in the incidence of neuroblastoma was seen in Denmark. The incidence increased from a level corresponding to that in Finland to a level corresponding to that in the USA, and the increase appears to be continuing. The increase relates to children aged under 5 years, an...

journal_title：British journal of cancer

authors： Carlsen NL

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...

journal_title：British journal of cancer

authors： Ng SP,Bahig H,Jethanandani A,Sturgis EM,Johnson FM,Elgohari B,Gunn GB,Ferrarotto R,Phan J,Rosenthal DI,Frank SJ,Fuller CD,Garden AS

更新日期：2020-10-14 00:00:00

abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...

journal_title：British journal of cancer

authors： Coupland CA,Chilvers CE,Davey G,Pike MC,Oliver RT,Forman D

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...

journal_title：British journal of cancer

authors： Tuhkuri A,Saraswat M,Mäkitie A,Mattila P,Silén R,Dickinson A,Carpén T,Tohmola T,Joenväärä S,Renkonen S

更新日期：2018-07-01 00:00:00

abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

journal_title：British journal of cancer

authors： Bálint E E,Vousden KH

更新日期：2001-12-14 00:00:00

abstract：BACKGROUND:CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to dete...

journal_title：British journal of cancer

authors： Alexandre J,Brown C,Coeffic D,Raban N,Pfisterer J,Mäenpää J,Chalchal H,Fitzharris B,Volgger B,Vergote I,Pisano C,Ferrero A,Pujade-Lauraine E

更新日期：2012-02-14 00:00:00

abstract：:The ability of the sister chromatid exchange (SCE) assay to detect heterogeneity in intrinsic radiation sensitivity was investigated. In order to identify tumour cell subpopulations, frequency histograms of cis-diamminedichloroplatinum (II) (cPt)-induced SCEs were generated and compared to those from cultures that had...

journal_title：British journal of cancer

authors： Tofilon PJ,Vines CM,Meyn RE,Wike J,Brock WA

更新日期：1989-01-01 00:00:00

abstract：:Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 i...

journal_title：British journal of cancer

authors： Yousef GM,Scorilas A,Magklara A,Memari N,Ponzone R,Sismondi P,Biglia N,Abd Ellatif M,Diamandis EP

更新日期：2002-11-18 00:00:00

abstract：:Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the changes within the major ...

journal_title：British journal of cancer

authors： Hearle N,Humphreys J,Damato BE,Wort R,Talaban R,Wixey J,Green H,Easton DF,Houlston RS

更新日期：2003-11-17 00:00:00

abstract：:HMGI-C belongs to the high-mobility-group-protein (HMG) family of architectural transcription factors and considerable interest has recently been shown in its expression in neoplastic tissues and apparent involvement in tumorigenesis. We could previously demonstrate an expression of HMGI-C mRNA in the peripheral blood...

journal_title：British journal of cancer

authors： Langelotz C,Schmid P,Jakob C,Heider U,Wernecke KD,Possinger K,Sezer O

更新日期：2003-05-06 00:00:00

abstract：:This report presents the results of a study into the effect of breast self-examination (BSE) in a large defined population within the City of Nottingham since 1979. We have examined the effect of breast self-examination in a group of patients invited to attend for education in BSE compared with a group of historical c...

journal_title：British journal of cancer

authors： Locker AP,Caseldine J,Mitchell AK,Blamey RW,Roebuck EJ,Elston CW

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...

journal_title：British journal of cancer

authors： von Bueren AO,Bacolod MD,Hagel C,Heinimann K,Fedier A,Kordes U,Pietsch T,Koster J,Grotzer MA,Friedman HS,Marra G,Kool M,Rutkowski S

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:A combination of S-1 and cisplatin has been shown to be effective with acceptable safety for the first-line treatment of far-advanced gastric cancer in Japan. This is the first randomised phase II trial to compare S-1+paclitaxel with S-1+cisplatin in this setting. METHODS:Patients with unresectable and/or r...

journal_title：British journal of cancer

authors： Mochiki E,Ogata K,Ohno T,Toyomasu Y,Haga N,Fukai Y,Aihara R,Ando H,Uchida N,Asao T,Kuwano H,North Kanto Gastric Cancer Study Group.

更新日期：2012-06-26 00:00:00

abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...

journal_title：British journal of cancer

authors： Connell JR

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...

journal_title：British journal of cancer

authors： Saunders EJ,Dadaev T,Leongamornlert DA,Al Olama AA,Benlloch S,Giles GG,Wiklund F,Gronberg H,Haiman CA,Schleutker J,Nordestgaard BG,Travis RC,Neal D,Pasayan N,Khaw KT,Stanford JL,Blot WJ,Thibodeau SN,Maier C,Kibel AS

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes. METHODS:Ovid MEDLINE and EMBASE were searched ...

journal_title：British journal of cancer

authors： Mei Z,Liu Y,Liu C,Cui A,Liang Z,Wang G,Peng H,Cui L,Li C

更新日期：2014-03-18 00:00:00