Abstract:
:The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of docetaxel 100 mg m(-2) (arm A, n=51) or docetaxel 60 mg m(-2) with irinotecan 200 mg m(-2) (arm B, n=49). Neither arm met the formal feasibility criterion of an eight-cycle treatment completion rate that was statistically greater than 60% (arm A 71% (90% confidence interval (CI) 58-81%; P=0.079; arm B 67% (90% CI 55-78%; P=0.184)). Median-dose intensities were >85% of planned dose for all agents. In arms A and B, 15.6 and 12.2% of patients, respectively, withdrew owing to treatment-related toxicity. Grade 3-4 sensory neurotoxicity was more common in arm A (1.9 vs 0%) and grade 3-4 diarrhoea was more common in arm B (0.6 vs 3.5%). Of patients with radiologically evaluable disease at baseline, 50 and 48% responded to therapy in arms A and B, respectively; at median 17.1 months' follow-up, median progression-free survival was 17.1 and 15.9 months, respectively. Although both arms just failed to meet the formal statistical feasibility criteria, the observed completion rates of around 70% were reasonable. The addition of irinotecan to first-line carboplatin and docetaxel chemotherapy was generally well tolerated although associated with increased gastrointestinal toxicity. Further exploratory studies of topoisomerase-I inhibitors in this setting may be warranted.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Clamp AR,Mäenpää J,Cruickshank D,Ledermann J,Wilkinson PM,Welch R,Chan S,Vasey P,Sorbe B,Hindley A,Jayson GC,Scottish Gynaecological Cancer Trials Group.doi
10.1038/sj.bjc.6602910subject
Has Abstractpub_date
2006-01-16 00:00:00pages
55-61issue
1eissn
0007-0920issn
1532-1827pii
6602910journal_volume
94pub_type
临床试验,杂志文章,随机对照试验abstract::Protein kinase B/Akt has been described as a central mediator of anti-apoptotic signals transduced by the PI3 kinase. Although the role of Akt in the suppression of apoptosis is well elucidated, a potential function of Akt in tumorigenesis and chemoresistance is less intensively documented. In this study, we describe ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600566
更新日期:2002-10-07 00:00:00
abstract::Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who had low excretion of ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1993.295
更新日期:1993-07-01 00:00:00
abstract::Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.520
更新日期:1995-12-01 00:00:00
abstract::Molecular and immunohistochemical studies of genetic events on chromosome 17p were prospectively compared with conventional clinical and pathological parameters and disease behaviour at a minimum of 72 months follow-up. In a series of 91 patients with primary operable breast cancer, 37 out of 91 (41%) patients had dis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.129
更新日期:1998-03-01 00:00:00
abstract::Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601614
更新日期:2004-02-09 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor receptor-3 (VEGFR-3) signalling mediates lymphangiogenesis and lymphatic invasion; however, the effect of VEGFR-3 inhibition on the lymph node (LN) metastasis remains unclear. The aim of this study is to clarify the benefit of a VEGFR-3 inhibitor Ki23057 for LN metastasis. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605296
更新日期:2009-10-06 00:00:00
abstract::Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1974.123
更新日期:1974-08-01 00:00:00
abstract::Anti-vascular effects of the novel Vinca alkaloid, vinflunine have been investigated in the MAC 15A transplantable murine colon adenocarcinoma model and compared with those induced by the most recently identified clinically useful third generation Vinca. Administration of the maximum tolerated dose of either vinflunin...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1587
更新日期:2001-01-01 00:00:00
abstract::Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604296
更新日期:2008-04-08 00:00:00
abstract::NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. We have previously characterized a homozygous point mutation in the BE human colon carcinoma cell line that leads...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.11
更新日期:1997-01-01 00:00:00
abstract::'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1824
更新日期:2001-06-01 00:00:00
abstract::We have investigated the influence of tumour cell DNA content (ploidy) on survival of 416 patients undergoing excisional surgery for colorectal cancer. Two hundred and eleven (51%) tumours had an abnormal DNA content (aneuploid or tetraploid). There was no correlation between ploidy status, sex, age and pathological s...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.393
更新日期:1990-11-01 00:00:00
abstract::Wnt genes are transforming to mouse breast epithelium and are hormonally regulated in vivo. To assess their role in another endocrine-responsive human cancer, the expression of seven Wnt genes (Wnt 2, 3, 4, 5a, 7a, 7b and 10b) in normal human endometrium and endometrial cells, and endometrial carcinoma tissues and cel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.195
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decrease...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0707-z
更新日期:2020-03-01 00:00:00
abstract::The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.310
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0580-9
更新日期:2019-11-01 00:00:00
abstract::The brain-specific angiogenesis inhibitor 1 gene has been isolated in an attempt to find fragments with p53 "functional" binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its par...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600067
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0523-5
更新日期:2019-08-01 00:00:00
abstract::Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.104
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/bjc.2013.378
更新日期:2013-08-06 00:00:00
abstract::Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resectio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604177
更新日期:2008-02-12 00:00:00
abstract:BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2011.104
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.405
更新日期:2012-10-23 00:00:00
abstract:BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.144
更新日期:2013-05-28 00:00:00
abstract::Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0948
更新日期:2000-01-01 00:00:00
abstract::SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is an anti-tumour agent that has a highly selective toxicity to hypoxic cells. In this study we delineate the role of several different bioreductive enzymes in the metabolism of SR 4233 by two tumour cell lines HT 1080 (human fibrosarcoma) and SCCVII (mouse carcinoma)....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.59
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01049-3
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk. TERTp-mut creates a binding site for Ets/TCF transc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.538
更新日期:2014-11-11 00:00:00
abstract::We used data from a prospective cohort study of twins to investigate the influence of unmeasured genetic and measured and unmeasured environmental factors on the smoking behaviour of adolescents and young adults. Twins were surveyed in 1988 (aged 11-18 years), 1991, 1996 and 2004 with data from 1409, 1121, 732 and 758...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604250
更新日期:2008-04-22 00:00:00
abstract::HER-2/neu is a tumour antigen that is overexpressed in human breast tumours. Among the vaccine strategies developed to overcome immune tolerance to self-proteins, vaccination with anti-idiotypic (anti-Id) antibodies has been described as a promising approach for treatment of several malignant diseases. To develop an a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601825
更新日期:2004-05-17 00:00:00