Abstract：
:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles share binding motifs, designated HLA-A3 supertype alleles, and because the Lck is preferentially expressed in metastatic cancer. Twenty-one Lck-derived peptides were prepared based on the binding motif to the HLA-A3 supertype alleles. They were first screened for their recognisability by immunoglobulin G (IgG) in the plasma of prostate cancer patients, and the selected candidates were subsequently tested for their potential to induce peptide-specific CTLs from peripheral blood mononuclear cells of HLA-A3 supertype(+) cancer patients. As a result, four Lck peptides were frequently recognised by IgGs, and three of them - Lck(90-99), Lck(449-458), and Lck(450-458) - efficiently induced peptide-specific and cancer-reactive CTLs. Their cytotoxicity towards cancer cells was mainly ascribed to HLA class I-restricted and peptide-specific CD8(+) T cells. These results indicate that these three Lck peptides are applicable to HLA-A3 supertype(+) cancer patients, especially those with metastasis. This information could facilitate the development of peptide-based anti-cancer vaccine for patients with alleles other than HLA-A2 and -A24.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada Mdoi
10.1038/sj.bjc.6604071subject
Has Abstractpub_date
2007-12-17 00:00:00pages
1648-54issue
12eissn
0007-0920issn
1532-1827pii
6604071journal_volume
97pub_type
杂志文章abstract：:In a population-based prospective study of 19,998 Japanese individuals, consumption of vegetables, green-yellow and green leafy vegetables was inversely associated with the risk of hepatocellular carcinoma (101 cases), with multivariable hazard ratios for the highest vs lowest tertile of 0.61 (95% confidence interval ...
journal_title：British journal of cancer
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doi：10.1038/sj.bjc.6604843
更新日期：2009-01-13 00:00:00
abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603029
更新日期：2006-03-27 00:00:00
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journal_title：British journal of cancer
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doi：10.1038/sj.bjc.6602704
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journal_title：British journal of cancer
pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.418
更新日期：1992-12-01 00:00:00
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journal_title：British journal of cancer
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journal_title：British journal of cancer
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doi：10.1038/sj.bjc.6602713
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605024
更新日期：2009-05-05 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600598
更新日期：2002-11-04 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.88
更新日期：1992-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605660
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.269
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journal_title：British journal of cancer
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journal_title：British journal of cancer
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journal_title：British journal of cancer
pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1989-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
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journal_title：British journal of cancer
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doi：10.1038/bjc.2013.692
更新日期：2014-01-07 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690183
更新日期：1999-03-01 00:00:00
abstract：:Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biop...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1998.654
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