Vegetable, fruit and antioxidant nutrient consumption and subsequent risk of hepatocellular carcinoma: a prospective cohort study in Japan.

abstract：:Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...

journal_title：British journal of cancer

authors： Makkar R,Butt J,Huang WY,McGlynn KA,Koshiol J,Pawlita M,Waterboer T,Freedman ND,Murphy G

更新日期：2020-09-01 00:00:00

abstract：:In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. In this study, we performed mutatio...

journal_title：British journal of cancer

authors： Zuidervaart W,van Nieuwpoort F,Stark M,Dijkman R,Packer L,Borgstein AM,Pavey S,van der Velden P,Out C,Jager MJ,Hayward NK,Gruis NA

更新日期：2005-06-06 00:00:00

abstract：:The relationship between circulating C-reactive protein concentrations and potential cytokine and receptor mediators (interleukin-6, leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), soluble IL-6 receptor, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and interleukin-8 (IL...

journal_title：British journal of cancer

authors： McKeown DJ,Brown DJ,Kelly A,Wallace AM,McMillan DC

更新日期：2004-12-13 00:00:00

abstract：:The duration of the DNA synthesis period in normal and malignant human tissues from the larynx, trachea bronchus and esophagus of 13 patient has been estimated by a tritiated thymidine, carbon-14 thymidine double-labeling method in vitro. The DNA synthesis times range from approximately 10 to 25 hours, are shortest in...

journal_title：British journal of cancer

authors： Fabrikant JI

更新日期：1970-03-01 00:00:00

abstract：:Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastas...

journal_title：British journal of cancer

authors： Paterson CR,Robins SP,Horobin JM,Preece PE,Cuschieri A

更新日期：1991-11-01 00:00:00

abstract：:In vitro cloned lines derived from a primary nickel-induced rat rhabdomyosarcoma exhibited diverse levels of susceptibility to spontaneous NK activity. The presence of NK target structures was revealed by competition assays on all cloned cell lines, and the NK susceptibility of the tumour lines varied according to the...

journal_title：British journal of cancer

authors： Poupon MF,Judde JG,Pot-Deprun J,Sweeney F,Lespinats G

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-...

journal_title：British journal of cancer

authors： Bessell EM,Bouliotis G,Armstrong S,Baddeley J,Haynes AP,O'Connor S,Nicholls-Elliott H,Bradley M

更新日期：2012-07-24 00:00:00

abstract：:In oncology, prognostic markers are clinical measures used to help elicit an individual patient's risk of a future outcome, such as recurrence of disease after primary treatment. They thus facilitate individual treatment choice and aid in patient counselling. Evidence-based results regarding prognostic markers are the...

journal_title：British journal of cancer

authors： Riley RD,Sauerbrei W,Altman DG

更新日期：2009-04-21 00:00:00

abstract：:The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...

journal_title：British journal of cancer

authors： Wolf DA,Kohlhuber F,Schulz P,Fittler F,Eick D

更新日期：1992-03-01 00:00:00

abstract：:The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

journal_title：British journal of cancer

authors： Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

更新日期：1993-05-01 00:00:00

abstract：:Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...

journal_title：British journal of cancer

authors： Wang ZJ,Churchman M,Campbell IG,Xu WH,Yan ZY,McCluggage WG,Foulkes WD,Tomlinson IP

更新日期：1999-04-01 00:00:00

abstract：:Photodynamic diagnosis and therapy have emerged as a promising tool in oncology. Using the visible fluorescence from photosensitisers excited by light, clinicians can both identify and treat tumour cells in situ. Protoporphyrin IX, produced in the penultimate step of the haem synthesis pathway, is a naturally occurrin...

journal_title：British journal of cancer

authors： McNicholas K,MacGregor MN,Gleadle JM

更新日期：2019-10-01 00:00:00

abstract：:Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ an...

journal_title：British journal of cancer

authors： Kadagidze ZG,Tupitsyn NN,Baryshnikov AJ,Kadyrov KP,Blinov VM,Bernard A,Amiot M,Boumsell L

更新日期：1990-02-01 00:00:00

abstract：:Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...

journal_title：British journal of cancer

authors： Champion HR,Wallace IW,Prescott RJ

更新日期：1972-04-01 00:00:00

abstract：:Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suita...

journal_title：British journal of cancer

authors： Elsheikh SE,Green AR,Rakha EA,Samaka RM,Ammar AA,Powe D,Reis-Filho JS,Ellis IO

更新日期：2008-07-22 00:00:00

abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...

journal_title：British journal of cancer

authors： Lindahl T

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...

journal_title：British journal of cancer

authors： Takahashi Y,Sakaguchi K,Horio H,Hiramatsu K,Moriya S,Takahashi K,Kawakita M

更新日期：2015-11-17 00:00:00

abstract：:The expression of heat shock proteins (HSP) of the 65 kD family (groEL) has been observed by flow cytometry using murine monoclonal antibody (MoAb) anti-HSP 65 kD (ML30) on the surface of B (Daudi) or T (H9) lymphoma cells, on a monocyte cell line (U937) and also on a primary culture of a human pancreatic carcinoma (H...

journal_title：British journal of cancer

authors： Poccia F,Piselli P,Di Cesare S,Bach S,Colizzi V,Mattei M,Bolognesi A,Stirpe F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line an...

journal_title：British journal of cancer

authors： van Breeschoten J,Wouters MWJM,Hilarius DL,Haanen JB,Blank CU,Aarts MJB,van den Berkmortel FWPJ,de Groot JB,Hospers GAP,Kapiteijn E,Piersma D,van Rijn RS,Suijkerbuijk KPM,Blokx WAM,Tije BJT,Veldt AAMV,Vreugdenhil A,Boer

更新日期：2021-01-26 00:00:00

abstract：:A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and...

journal_title：British journal of cancer

authors： Pathak S,Nemeth MA,Multani AS,Thalmann GN,von Eschenbach AC,Chung LW

更新日期：1997-01-01 00:00:00

abstract：:Since hyperinsulinaemia may promote obesity-linked cancers, we compared type 2 diabetes prevalence among oesophageal adenocarcinoma (OAC) patients and population controls. Diabetes increased the risk of OAC (adjusted odds ratio 1.59, 95% confidence interval (CI) 1.04-2.43), although the risk was attenuated after furth...

journal_title：British journal of cancer

authors： Neale RE,Doecke JD,Pandeya N,Sadeghi S,Green AC,Webb PM,Whiteman DC,Australian Cancer Study.

更新日期：2009-03-10 00:00:00

abstract：BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...

journal_title：British journal of cancer

authors： Wang X,Zhao L,Liu H,Zhong D,Liu W,Shan G,Dong F,Gao W,Bai C,Li X

更新日期：2016-06-14 00:00:00

abstract：:The pharmacological interest in lonidamine is related to its ability to enhance the cytotoxic effects of several DNA-damaging anti-tumour agents. This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinom...

journal_title：British journal of cancer

authors： De Cesare M,Pratesi G,Giusti A,Polizzi D,Zunino F

更新日期：1998-01-01 00:00:00

abstract：:6-Mercaptopurine (MP)-sensitive and -resistant cell culture lines were used to further characterize the apparent ability of MP nucleotide derivatives to overcome resistance to the parent drug. 6-Mercaptopurine-9-beta-D-ribofuranoside 5'-monophosphate [MPRP], bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5', 5"'-monoph...

journal_title：British journal of cancer

authors： Johnston HP,Hawley P,White SE,Gibson I,Tidd DM

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies. METHODS:We detected ALK protein expression by immunohistochemistry and gene rearrangements by fluorescenc...

journal_title：British journal of cancer

authors： Amatu A,Somaschini A,Cerea G,Bosotti R,Valtorta E,Buonandi P,Marrapese G,Veronese S,Luo D,Hornby Z,Multani P,Murphy D,Shoemaker R,Lauricella C,Giannetta L,Maiolani M,Vanzulli A,Ardini E,Galvani A,Isacchi A,Sartore

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure to infectious agents, normal delivery, and exposure to animals in early life) have been suggested to decrease the risk of childhood acute lymphoblastic leukaemia (ALL). METHODS:The national registry-based case-con...

journal_title：British journal of cancer

authors： Ajrouche R,Rudant J,Orsi L,Petit A,Baruchel A,Lambilliotte A,Gambart M,Michel G,Bertrand Y,Ducassou S,Gandemer V,Paillard C,Saumet L,Blin N,Hémon D,Clavel J

更新日期：2015-03-17 00:00:00

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) and juvenile polyposis (JPS) are both characterized by the presence of hamartomatous polyps and increased risk of malignancy in the gastrointestinal tract. Mutations of the LKB1 and SMAD4 genes have been shown recently to cause a number of PJS and JPS cases respectively, but there remains ...

journal_title：British journal of cancer

authors： Woodford-Richens KL,Halford S,Rowan A,Bevan S,Aaltonen LA,Wasan H,Bicknell D,Bodmer WF,Houlston RS,Tomlinson IP

更新日期：2001-05-18 00:00:00

abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...

journal_title：British journal of cancer

authors： Downing A,Aravani A,Macleod U,Oliver S,Finan PJ,Thomas JD,Quirke P,Wilkinson JR,Morris EJ

更新日期：2013-02-19 00:00:00

abstract：:The effects of X-radiation on the Nembutal-induced redistribution of the cardiac output in two types of transplanted mouse tumours and some normal mouse tissues have been investigated, using rubidium-86 and 125I-human serum albumin. Irradiation causes an increase in 86Rb uptake (relative blood perfusion) by the tumour...

journal_title：British journal of cancer

authors： Zanelli GD,Lucas PB

更新日期：1976-10-01 00:00:00