Abstract:
:Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suitability as markers of basal-like phenotype. Caveolin-1 and CAV2 protein expression was assessed on a tissue microarray containing 880 unselected invasive breast cancer cases, by means of immunohistochemistry. Caveolin-1 and CAV2 expression was observed in 13.4 and 5.9% of all breast cancer, respectively. Their expression was strongly associated with high histological grade, lack of steroid hormone receptor positivity (ER and PR), and expression of basal markers (basal cytokeratins, P63, P-cadherin). Furthermore, there was a significant association between CAV1 and CAV2 expression and basal-like phenotype. On univariate analysis only CAV2 had a prognostic impact on breast cancer-specific survival; however, this was not independent from other traditional markers on multivariate analysis. Our results demonstrate that both CAV1 and CAV2 are associated with basal-like phenotype. Further studies are warranted to determine whether they play an oncogenic role in basal-like/triple-negative breast cancer development or are just surrogate markers for this subgroup.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Elsheikh SE,Green AR,Rakha EA,Samaka RM,Ammar AA,Powe D,Reis-Filho JS,Ellis IOdoi
10.1038/sj.bjc.6604463subject
Has Abstractpub_date
2008-07-22 00:00:00pages
327-34issue
2eissn
0007-0920issn
1532-1827pii
6604463journal_volume
99pub_type
杂志文章abstract:BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.63
更新日期:2015-03-31 00:00:00
abstract:BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.223
更新日期:2014-05-27 00:00:00
abstract::To test the feasibility and efficacy of epirubicin and ifosfamide added to first-line chemotherapy with cisplatin and paclitaxel in a phase II randomised clinical trial. Patients with histologically proven epithelial ovarian cancer were randomly assigned to receive first-line polychemotherapy with cisplatin/paclitaxel...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6604231
更新日期:2008-02-26 00:00:00
abstract::The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- di...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.9
更新日期:1981-01-01 00:00:00
abstract::Functionally active telomerase is affected at various steps including transcriptional and post-transcriptional levels of major telomerase components (hTR and human telomerase reverse transcriptase (hTERT)). We therefore developed a rapid and sensitive method to quantify hTERT and its splicing variants as well as the h...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602546
更新日期:2005-05-23 00:00:00
abstract:BACKGROUND:It has been reported that although young patients present with more advanced disease, when adjusted for stage, cancer-specific survival is not different after surgery for colorectal cancer. However, few studies have examined non-cancer survival in young patients and 10-year survival has rarely been reported....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605222
更新日期:2009-08-18 00:00:00
abstract:BACKGROUND:To describe the prescription patterns of analgesics during the last 3 months of life in lung cancer and to determine the associated factors. METHODS:Data on lung cancer patients (N=10,202) who died during 2000-2008 were extracted from the General Practice Research Database (GPRD). This database records pres...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.150
更新日期:2011-05-24 00:00:00
abstract::A death certificate-based case-control study was conducted on 207 women aged 25-44 who died of bladder cancer in England and Wales in the period 1971-89 and 411 controls matched on sex, year of death and age at death. An odds ratio of 12.0 (95% CI 1.5-99.7) was found for women with a history of paraplegia. Four of the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.269
更新日期:1994-07-01 00:00:00
abstract::The efficacy of radioimmunotherapy of tumours with radiolabelled monoclonal antibodies (MAbs) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. In the case of MAbs directed against intracellular antigens, increasing the permeability of the cytoplasmic membrane may augment t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.468
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...
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pub_type: 杂志文章
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更新日期:2017-01-03 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.337
更新日期:2014-08-12 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2011-04-12 00:00:00
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.2013.158
更新日期:2013-04-30 00:00:00
abstract::The in vitro deamination, cytotoxicity, cellular drug uptake, distribution and cellular pharmacology in HL-60 cells of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a lipophilic derivative of arabinofuranosylcytosine (ara-C), were studied. Compared with ara-C, NHAC in liposomal formulations was highly resista...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.185
更新日期:1995-05-01 00:00:00
abstract::This randomised trial compared platinum-based to anthracycline-based chemotherapy in patients with small-cell lung cancer (limited or extensive stage) and journal_title:British journal of cancer pub_type: 杂志文章,随机对照试验 doi:10.1038/sj.bjc.6604480 更新日期:2008-08-05 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6603415
更新日期:2006-11-06 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2011.585
更新日期:2012-01-31 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604348
更新日期:2008-05-06 00:00:00
abstract::Maturation of monocytes into macrophages in vitro has been assayed by a quantitative microtitre assay in patients with squamous-cell carcinoma of the lung. Monocyte maturation in autologous serum was significantly depressed in patients with both limited and extensive disease compared with normal controls, patients wit...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.71
更新日期:1981-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6603968
更新日期:2007-10-08 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1988-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602029
更新日期:2004-08-31 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602054
更新日期:2004-08-31 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.410
更新日期:2012-10-09 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0359-4
更新日期:2019-02-01 00:00:00
abstract::In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604292
更新日期:2008-04-08 00:00:00
abstract::The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block i...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1993.325
更新日期:1993-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.310
更新日期:1998-06-01 00:00:00