Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project.

abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...

journal_title：British journal of cancer

authors： Boeck S,Wittwer C,Heinemann V,Haas M,Kern C,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-04-30 00:00:00

abstract：:The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted radiotherapy, an alternative strategy for brain tumour treatment that offers the exciting pro...

journal_title：British journal of cancer

authors： Zalutsky MR

更新日期：2004-04-19 00:00:00

abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...

journal_title：British journal of cancer

authors： Coupland CA,Chilvers CE,Davey G,Pike MC,Oliver RT,Forman D

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers. The mechanism(s) underlying deregulated expression and the clinical consequences of changes in expression are ...

journal_title：British journal of cancer

authors： Wang H,Lee S,Nigro CL,Lattanzio L,Merlano M,Monteverde M,Matin R,Purdie K,Mladkova N,Bergamaschi D,Harwood C,Syed N,Szlosarek P,Briasoulis E,McHugh A,Thompson A,Evans A,Leigh I,Fleming C,Inman GJ,Hatzimichael E,

更新日期：2012-04-10 00:00:00

abstract：:Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...

journal_title：British journal of cancer

authors： Houston A,Bennett MW,O'Sullivan GC,Shanahan F,O'Connell J

更新日期：2003-10-06 00:00:00

abstract：:Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...

journal_title：British journal of cancer

authors： De Lorenzo C,Troise F,Cafaro V,D'Alessio G

更新日期：2007-11-19 00:00:00

abstract：:In the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250 mg of FA. 5-MTHF rapidly appeared in plasma, the maximu...

journal_title：British journal of cancer

authors： Thyss A,Milano G,Etienne MC,Paquis P,Roche JL,Grelier P,Schneider M

更新日期：1989-04-01 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：:Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...

journal_title：British journal of cancer

authors： de Jong JS,van Diest PJ,Baak JP

更新日期：2000-01-01 00:00:00

abstract：:A study was conducted on the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on peroxisomal enzyme activities in mouse embryo fibroblasts C3H/10T1/2 C18 cells and chemically transformed C3H/10T1/2 MCA16 cells. TPA is a potent tumour promoter and treatment with this compound of the two cell lines induced peroxis...

journal_title：British journal of cancer

authors： Lillehaug JR,Berge RK

更新日期：1986-01-01 00:00:00

abstract：:DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...

journal_title：British journal of cancer

authors： Jaeckle KA,Phuphanich S,Bent MJ,Aiken R,Batchelor T,Campbell T,Fulton D,Gilbert M,Heros D,Rogers L,O'Day SJ,Akerley W,Allen J,Baidas S,Gertler SZ,Greenberg HS,LaFollette S,Lesser G,Mason W,Recht L,Wong E,Chamber

更新日期：2001-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or sp...

journal_title：British journal of cancer

authors： Ward DG,Suggett N,Cheng Y,Wei W,Johnson H,Billingham LJ,Ismail T,Wakelam MJ,Johnson PJ,Martin A

更新日期：2006-06-19 00:00:00

abstract：:The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child's immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprisi...

journal_title：British journal of cancer

authors： Schüz J,Kaletsch U,Meinert R,Kaatsch P,Michaelis J

更新日期：1999-05-01 00:00:00

abstract：:The present study was designed in order to evaluate the response rate and the toxicity of continuous infusion of Interleukin 2 (IL2) in patients over 65 with metastatic renal cell carcinoma. Twenty-five patients, median age 69 (range 65-77), without any prior systemic anticancer therapy received a continuous infusion ...

journal_title：British journal of cancer

authors： Négrier S,Mercatello A,Bret M,Thiesse P,Blay JY,Coronel B,Merrouche Y,Oskam R,Franks CR,Clavel M

更新日期：1992-05-01 00:00:00

abstract：:Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988...

journal_title：British journal of cancer

authors： Bucchi L,Barchielli A,Ravaioli A,Federico M,De Lisi V,Ferretti S,Paci E,Vettorazzi M,Patriarca S,Frigerio A,Buiatti E,SCREENREG Working Group.

更新日期：2005-01-17 00:00:00

abstract：BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...

journal_title：British journal of cancer

authors： Xie C,Jing Z,Luo H,Jiang W,Ma L,Hu W,Zheng A,Li D,Ding L,Zhang H,Xie C,Lian X,Du D,Chen M,Bian X,Tan B,Xia B,Xie R,Liu Q,Wang L,Wu S

更新日期：2020-11-01 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2004-01-12 00:00:00

abstract：:To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...

journal_title：British journal of cancer

authors： Jammes H,Peyrat JP,Ban E,Vilain MO,Haour F,Djiane J,Bonneterre J

更新日期：1992-08-01 00:00:00

abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...

journal_title：British journal of cancer

authors： Cubeddu LX,Hoffmann IS,Fuenmayor NT,Malave JJ

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：:L-Glutamine is a requirement for many cells in tissue culture, an intermediate in many metabolic pathways, and an alternative substrate to glucose for energy metabolism. These properties suggest that glutamine concentration might be a determinant of cell viability in tumours, especially in regions that are deficient i...

journal_title：British journal of cancer

authors： Tannock IF,Steele D,Roberts J

更新日期：1986-11-01 00:00:00

abstract：:There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....

journal_title：British journal of cancer

authors： Campbell NC,Elliott AM,Sharp L,Ritchie LD,Cassidy J,Little J

更新日期：2001-04-06 00:00:00

abstract：:Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has be...

journal_title：British journal of cancer

authors： Yuen HF,Chan YP,Chan KK,Chu YY,Wong ML,Law SY,Srivastava G,Wong YC,Wang X,Chan KW

更新日期：2007-11-19 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

journal_title：British journal of cancer

authors： Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

更新日期：2005-04-25 00:00:00

abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...

journal_title：British journal of cancer

authors： Manning LS,Radin NS

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Biomarkers for metastatic castration-resistant prostatic cancer (mCRPC) are an unmet medical need. METHODS:The prognostic and predictive value for survival and response to salvage hormonal therapy (SHT) of baseline testosterone level (TL) was analysed in a cohort of 101 mCRPC patients participating in 9 non...

journal_title：British journal of cancer

authors： de Liaño AG,Reig O,Mellado B,Martin C,Rull EU,Maroto JP

更新日期：2014-04-29 00:00:00

abstract：:Combination chemotherapy with cytosine arabinoside, cyclophosphamide and L-asparaginase (Asnase) was given to 22 children with acute lymphocytic leukaemia (ALL) with a white-cell count greater than 30 X 10(9)/1, and other features suggestive of poor prognosis. Complete remission was induced in all patients--in 19 afte...

journal_title：British journal of cancer

authors： Ekert H,Waters KD,Smith PJ,Matthews RN,Ellis WM

更新日期：1978-11-01 00:00:00

abstract：:Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with ...

journal_title：British journal of cancer

authors： Dodd NJ,Silcock JM

更新日期：1976-11-01 00:00:00

abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

journal_title：British journal of cancer

authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

更新日期：2000-06-01 00:00:00

abstract：:Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb. (1)H magnetic resonance spectra of live cells showed an increase in methylene signal as well as methylene/methyl ratio of fatty acid side chains at 5 and 24 h foll...

journal_title：British journal of cancer

authors： Al-Saffar NM,Titley JC,Robertson D,Clarke PA,Jackson LE,Leach MO,Ronen SM

更新日期：2002-03-18 00:00:00