Abstract：
:The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child's immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprising more than 1000 children with acute leukaemia. Neither being the first-born child, nor a short duration of breastfeeding, indicators of a deficit in viral contacts during infancy or the number of infectious diseases, were significant risk factors. We observed a strong association with fewer routine immunizations with a 3.2-fold increase for those children getting less than four immunizations, but this association could partly be explained by reporting bias. While tonsillectomy or appendectomy increased the risk of leukaemia in our studies, a protective effect of allergies could be seen. In summary, we found only weak support for the delayed exposure hypothesis. To some extent this may be due to the chosen surrogate markers which reflect, rather indirectly, immunological isolation in infancy and delayed exposure to common viruses. However, the significant findings for routine immunizations, tonsillectomy and allergies of the child or its parents merit further investigation.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Schüz J,Kaletsch U,Meinert R,Kaatsch P,Michaelis Jdoi
10.1038/sj.bjc.6690395subject
Has Abstractpub_date
1999-05-01 00:00:00pages
585-90issue
3-4eissn
0007-0920issn
1532-1827journal_volume
80pub_type
杂志文章abstract：:The results of treating two series of patients with Burkitt's lymphoma are presented in the form of survival curves. The second series shows an improved survival rate which seems to be due to a potentiating effect by potassium iodide on oral cyclophosphamide. So far no reason for this effect has been found. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.6
更新日期：1971-03-01 00:00:00
abstract：:We investigated whether dietary intakes of total fat, monounsaturated fat (MUFA), polyunsaturated fat (PUFA) and saturated fat (SFA) were associated with breast cancer risk in a prospective cohort of 49 261 Swedish women (30-49 years at enrolment), which yielded 974 breast cancer cases by December 2005. Further, we ev...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604033
更新日期：2007-12-03 00:00:00
abstract：:Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601570
更新日期：2004-02-09 00:00:00
abstract：:Oestrogen receptor alpha (ER-alpha) gene has two specific promoters, distal (P0) and proximal (P1), which induce almost identical transcripts in size due to different splicing. We examined the methylation at both promoter regions of the ER-alpha gene using HpaII, a methylation-sensitive restriction enzyme, prior to po...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690631
更新日期：1999-08-01 00:00:00
abstract：:Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation. The extracellular immunoglobulin (IgG)-like domains II and III are responsible for ligand binding; alternative usa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601249
更新日期：2003-10-06 00:00:00
abstract：BACKGROUND:Tumour stromal cells differ from its normal counterpart. We have shown that tumour endothelial cells (TECs) isolated from tumour tissues are also abnormal. Furthermore, we found that mRNAs of vascular endothelial growth factor-A (VEGF-A) and cyclooxygenase-2 (COX-2) were upregulated in TECs. Vascular endothe...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.20
更新日期：2011-03-01 00:00:00
abstract：:Acute inflammatory reactions were induced in rats by the intravenous injection of cellulose sulphate (CS) or an extract of normal rat lung homogenate (LH), or by intraperitoneal injections of Compound 48/80. These treatments greatly increased survival and clonogenic growth in the lungs of rats of intravenously injecte...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.189
更新日期：1974-09-01 00:00:00
abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-019-0505-7
更新日期：2019-07-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may c...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6690291
更新日期：1999-04-01 00:00:00
abstract：:Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.547
更新日期：1997-01-01 00:00:00
abstract：:Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.97
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Non-invasive biomarkers of disease progression in mice with cancer are lacking making it challenging to implement appropriate humane end points. We investigated whether body temperature, food and water consumption could be used to predict tumour burden. METHODS:Thirty-six male, wild-type C57Bl/6 mice were i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.818
更新日期：2014-02-18 00:00:00
abstract：:A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.156
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Faecal immunochemical tests (FITs) have replaced guaiac-based faecal occult blood test (gFOBTs) in several colorectal cancer (CRC) screening programmes. We aimed to evaluate the benefits of this transition based on the Wallonia-Brussels-organised CRC screening programme. METHODS:A total of 1,569,868 individ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0754-5
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.330
更新日期：2012-08-07 00:00:00
abstract：:The cell population kinetics of the transmissible venereal tumour of the dog was studied at two different stages of tumour growth using the labelled mitoses technique. At the first stage the tumours were growing with a doubling time of about 4 days; at the second stage their growth rate was limited, probably by an imm...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1972.54
更新日期：1972-10-01 00:00:00
abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.1993.147
更新日期：1993-04-01 00:00:00
abstract：:To investigate possible relationships between genetic alterations and hormonal deregulation during breast cancer development and/or progression, we examined 616 primary breast cancers for loss of heterozygosity (LOH) at chromosomal regions 16q24, 17p13.3 and 17q21, and for amplifications of the ERBB2 and c-MYC loci. A...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.89
更新日期：1995-03-01 00:00:00
abstract：:In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into func...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602476
更新日期：2005-04-11 00:00:00
abstract：:Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601454
更新日期：2004-01-12 00:00:00
abstract：:We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2,203,500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603713
更新日期：2007-05-07 00:00:00
abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.136
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.50
更新日期：2016-04-12 00:00:00
abstract：:Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.644
更新日期：1998-11-01 00:00:00
abstract：:Leukaemia L 1210 cells preincubated in vitro with neuraminidase preparations derived either from Vibrio cholerae (VCN) or Clostridium perfringens (CPN) lost their i.p. transplantability for normal DBA/2 mice. This loss of transplantability could not be observed when the enzyme treated cells were implanted in mice whos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.14
更新日期：1973-02-01 00:00:00
abstract：:A sedentary lifestyle, obesity, and a Westernized diet have been implicated in the aetiology of both colorectal cancer and non-insulin dependent diabetes mellitus, leading to the hypothesis that hyperinsulinaemia may promote colorectal cancer. We prospectively examined the association between colorectal cancer risk an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1582
更新日期：2001-02-02 00:00:00
abstract：:Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue of the British Journal of Cancer provide in vivo evidence that the degree to which various breast cancer cell lines acidify their e...
journal_title：British journal of cancer
pub_type： 社论
doi：10.1038/s41416-020-01171-2
更新日期：2021-01-01 00:00:00
abstract：:A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.421
更新日期：1990-12-01 00:00:00
abstract：:In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patie...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.242
更新日期：1996-05-01 00:00:00
abstract：:Regional lymph node metastasis is a very important prognostic indicator. In the metastatic process, reduction in cell to cell adhesion including E-cadherin-catenin cell adhesion complex is an essential step. We investigated immunohistochemical expression of E-cadherin, alpha-catenin and beta-catenin in 159 tissue samp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601124
更新日期：2003-08-04 00:00:00
