Abstract:
BACKGROUND:Non-invasive biomarkers of disease progression in mice with cancer are lacking making it challenging to implement appropriate humane end points. We investigated whether body temperature, food and water consumption could be used to predict tumour burden. METHODS:Thirty-six male, wild-type C57Bl/6 mice were implanted with subcutaneous RFID temperature sensors and inoculated with Eμ-myc tumours that infiltrate lymphoid tissue. RESULTS:Decrease in body temperature over the course of the study positively predicted post-mortem lymph node tumour burden (R(2)=0.68, F(1,22)=44.8, P<0.001). At experimental and humane end points, all mice that had a mean decrease in body temperature of 0.7 °C or greater had lymph nodes heavier than 0.5 g (100% sensitivity), whereas a mean decrease in body temperature <0.7 °C always predicted lymph nodes lighter than 0.5 g (100% specificity). The mean decrease in food consumption in each cage also predicted mean post-mortem lymph node tumour burden at 3 weeks (R(2)=0.89, F(1,3)=23.2, P=0.017). CONCLUSION:Temperature, food and water consumption were useful biomarkers of disease progression in mice with lymphoma and could potentially be used more widely to monitor mice with other forms of cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Hunter JE,Butterworth J,Perkins ND,Bateson M,Richardson CAdoi
10.1038/bjc.2013.818subject
Has Abstractpub_date
2014-02-18 00:00:00pages
928-34issue
4eissn
0007-0920issn
1532-1827pii
bjc2013818journal_volume
110pub_type
杂志文章abstract::The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.173
更新日期:1994-05-01 00:00:00
abstract::Cancer of the colon and rectum is one of the most frequent malignancies both in the US and Europe. Standard palliative therapy is based on 5-fluorouracil/folinic acid combinations, with or without oxaliplatin or irinotecan, given intravenously. Oral medication has the advantage of greater patient convenience and accep...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6600781
更新日期:2003-03-10 00:00:00
abstract::Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution de...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.252
更新日期:1991-07-01 00:00:00
abstract::An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.43
更新日期:1981-03-01 00:00:00
abstract::Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1628
更新日期:2001-02-01 00:00:00
abstract::Thirty-three patients with squamous cell carcinoma of the head and neck region were studied concerning p53 protein expression and mutations in exons 4-9 of the p53 gene using immunohistochemistry, polymerase chain reaction (PCR)-single strand conformation polymorphism analysis and DNA sequencing. Immunoreactivity was ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.159
更新日期:1995-04-01 00:00:00
abstract::Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the inf...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.281
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer. METHODS:A tissue microarray of 1420 primary colorectal cancers and 57 normal mucosa samples was immunostained for CD133, CD...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605762
更新日期:2010-07-27 00:00:00
abstract:BACKGROUND:The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. METHODS:From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605281
更新日期:2009-10-06 00:00:00
abstract::With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0938
更新日期:2000-01-01 00:00:00
abstract::Studies in animal models of mouse mammary carcinoma have shown that ovine submaxillary mucin, which carries multiple sialyl-Tn (STn) epitopes, is effective in stimulating an immune response and inhibiting tumour growth. In similar studies using carbohydrate antigens, pretreatment with low-dose cyclophosphamide has bee...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1996.532
更新日期:1996-10-01 00:00:00
abstract::This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,评审
doi:10.1038/sj.bjc.6690715
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to dete...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2011.593
更新日期:2012-02-14 00:00:00
abstract:BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2014.257
更新日期:2014-07-08 00:00:00
abstract::Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyse...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604142
更新日期:2008-01-15 00:00:00
abstract::I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.94
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.330
更新日期:2012-08-07 00:00:00
abstract:BACKGROUND:Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME is expressed in vari...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.187
更新日期:2016-08-09 00:00:00
abstract::The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.172
更新日期:1978-07-01 00:00:00
abstract::The cytotoxic mechanism of a conjugate of doxorubicin (DXR) and glutathione (GSH) via glutaraldehyde (GSH-DXR) was investigated using DXR-sensitive (AH66P) and -resistant (AH66DR) rat hepatoma cells. GSH-DXR accumulated in AH66DR cells as well as in AH66P cells without efflux by P-gp and exhibited the potent cytocidal...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.557
更新日期:1997-01-01 00:00:00
abstract::Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where su...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.270
更新日期:2014-10-14 00:00:00
abstract::Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.196
更新日期:1986-09-01 00:00:00
abstract::The ultrastructure of two lymphoblastoid cell lines derived from Marek's disease lymphomata has been studied. The cells varied from 5 to 12 mum in diameter and had large round or oval nuclei. A nucleolus was occasionally present and about 3% of cells showed projections of the nuclear envelope. The cytoplasm contained ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.2
更新日期:1975-01-01 00:00:00
abstract::Our purpose was to determine the response rate and median and overall survival of gemcitabine as monotherapy versus gemcitabine plus irinotecan in advanced or metastatic pancreatic cancer. Patients with histologically or cytologically confirmed adenocarcinoma who were chemotherapy and radiotherapy naive were enrolled....
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6603301
更新日期:2006-09-04 00:00:00
abstract:BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605381
更新日期:2009-11-17 00:00:00
abstract::The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curativ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601202
更新日期:2003-09-01 00:00:00
abstract::We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cell death was associated with phosphorylation and hence inactivation of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1818
更新日期:2001-06-01 00:00:00
abstract::Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600700
更新日期:2003-02-10 00:00:00
abstract:BACKGROUND:The overexpression of oestrogen-related receptor-β (ERRβ) in breast cancer patients is correlated with improved prognosis and longer relapse-free survival, and the level of ERRβ mRNA is inversely correlated with the S-phase fraction of cells from breast cancer patients. METHODS:Chromatin immunoprecipitation...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.53
更新日期:2014-04-15 00:00:00
abstract:BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in w...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.518
更新日期:2013-09-17 00:00:00