当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Differences in oestrogen receptors in malignant and normal breast tissue as identified by the binding of a new synthetic progestogen.

Differences in oestrogen receptors in malignant and normal breast tissue as identified by the binding of a new synthetic progestogen.

Abstract：

:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 soluble protein (Kd 2.1 X 10(-9)-1.4 X 10(-8) mol l-1). In normal breast tissue ERc levels were 33-640 fmol mg-1 soluble protein (Kd 1.3 X 10(-10)-3.2 X 10(-9) mol l-1), ERn was detected in only 2 samples, 8 and 87 fmol mg-1 soluble protein with Kd 3.2 X 10(-9) and 1.4 X 10(-9) l mol-1 respectively. 17 alpha-ethinyl-13 beta-ethyl-17 beta-hydroxy-4,15-gonadiene-3-one (gestodene), a new synthetic progestogen displaced 3H-oestradiol (3H-E2) from both ERc and ERn in malignant tissue but not in normal breast, or these receptors from endometrial tissue. In competition studies gestodene was approximately 3 times more effective in displacing 3H-E2 from ERc and ERn in malignant breast tissue than the natural ligand. Quantitation of ER by gestodene were ERc, 12-1134 fmol gestodene bound mg-1 soluble protein (Kd 1 X 10(-9)-8.1 X 10(-9) mol l-1); ERn, 17-531 fmol gestodene bound mg-1 soluble protein (Kd 1.6 X 10(-9)-1.1 X 10(-8) mol l-1). L-13-ethyl-17 alpha-ethinyl, 17 beta-hydroxy-gonen-3-one (levonorgestrel) showed no binding to ER in malignant breast, normal breast or endometrial tissue. In circulation both gestodene and levonorgestrel displaced E2 from sex hormone binding globulin more than any of the androgens tested. These results suggest that gestodene is a progestogen with oestrogenic and/or antioestrogenic properties and provide strong evidence for differences in ER from malignant and normal breast tissue.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Iqbal MJ,Colletta AA,Houmayoun-Valyani SD,Baum M

doi

10.1038/bjc.1986.196

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

447-52

issue

3

eissn

0007-0920

issn

1532-1827

journal_volume

54

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Cytogenetics of malignant epithelial cells and lymphoblastoid cell lines from nasopharyngeal carcinoma.

    abstract：:The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1978.31

    authors： Finerty S,Jarvis JE,Epstein MA,Trumper PA,Ball G,Giovanella BC

    更新日期：1978-02-01 00:00:00

  • Diminution of 37-kDa laminin binding protein expression reduces tumour formation of murine lung cancer cells.

    abstract：:Expression of the 37-kDa laminin binding protein (37LBP/p40), a precursor of the 67-kDa laminin receptor, is well-correlated with the biological aggressiveness of cancer cells. To elucidate the direct role played by 37LBP/p40 in cancer cells, a murine lung cancer cell line T11, the 37LBP/p40 expression of which was re...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690474

    authors： Satoh K,Narumi K,Abe T,Sakai T,Kikuchi T,Tanaka M,Shimo-Oka T,Uchida M,Tezuka F,Isemura M,Nukiwa T

    更新日期：1999-06-01 00:00:00

  • Metabolism of the broad-spectrum neuropeptide growth factor antagonist: [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P.

    abstract：:Broad-spectrum neuropeptide growth factor antagonists, such as [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P (antagonist D) and [Arg6, D-Trp7,9, NmePhe8]substance P(6-11) (antagonist G), are currently being investigated as possible anti-tumour agents. These compounds are hoped to be effective against neuropeptide-drive...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.126

    authors： Jones DA,Cummings J,Langdon SP,Maclellan AJ,Higgins T,Rozengurt E,Smyth JF

    更新日期：1996-03-01 00:00:00

  • Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16.

    abstract：:In the endeavour to develop a model for studying gene therapy of cancers associated with human papillomaviruses (HPVs), mouse cells were transformed with the HPV type 16 (HPV16) and activated H-ras oncogenes. This was done by cotransfection of plasmid p16HHMo, carrying the HPV16 E6/E7 oncogenes, and plasmid pEJ6.6, ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1615

    authors： Smahel M,Sobotková E,Bubeník J,Símová J,Zák R,Ludviková V,Hájková R,Kovarík J,Jelínek F,Povýsil C,Marinov J,Vonka V

    更新日期：2001-02-02 00:00:00

  • Randomised study of adjuvant chemotherapy for completely resected p-stage I-IIIA non-small cell lung cancer.

    abstract：:We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underw...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/sj.bjc.6603336

    authors： Nakagawa K,Tada H,Akashi A,Yasumitsu T,Iuchi K,Taki T,Kodama K,Osaka Lung Cancer Study Group, Japan.

    更新日期：2006-10-09 00:00:00

  • Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma: a phase II trial.

    abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.468

    authors： Hitre E,Budai B,Takácsi-Nagy Z,Rubovszky G,Tóth E,Remenár É,Polgár C,Láng I

    更新日期：2013-09-03 00:00:00

  • Quantification of the role of smoking and chewing tobacco in oral, pharyngeal, and oesophageal cancers.

    abstract：:The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.31

    authors： Jayant K,Balakrishnan V,Sanghvi LD,Jussawalla DJ

    更新日期：1977-02-01 00:00:00

  • 'Proteolytic switching': opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression.

    abstract：:Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690385

    authors： MacDougall JR,Bani MR,Lin Y,Muschel RJ,Kerbel RS

    更新日期：1999-05-01 00:00:00

  • Cytotoxic antibody in acute myeloblastic leukaemia during immunotherapy: lack of tumour specificity.

    abstract：:Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.40

    authors： Gale DG,MacLennan IC

    更新日期：1977-03-01 00:00:00

  • CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.

    abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.314

    authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

    更新日期：2013-07-23 00:00:00

  • Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis.

    abstract：:Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601913

    authors： Din FV,Dunlop MG,Stark LA

    更新日期：2004-07-19 00:00:00

  • Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2).

    abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca2+-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is oncogenic and overexpressed...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0675-3

    authors： James AD,Richardson DA,Oh IW,Sritangos P,Attard T,Barrett L,Bruce JIE

    更新日期：2020-01-01 00:00:00

  • Pharmacokinetics and cytotoxicity of RSU-1069 in subcutaneous 9L tumours under oxic and hypoxic conditions.

    abstract：:The acute toxicity, pharmacokinetics and hypoxic cytotoxicity of RSU-1069 were investigated using the subcutaneous (sc) rat 9L tumour model. The pharmacokinetics were studied after i.p. injection of RSU-1069 (20 mg kg-1 or 100 mg kg-1). For both doses, the elimination of RSU-1069 followed first-order kinetics in both ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1991.116

    authors： Wong KH,Koch CJ,Wallen CA,Wheeler KT

    更新日期：1991-04-01 00:00:00

  • Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.

    abstract：:Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01105-y

    authors： Mout L,Moll JM,Chen M,de Morrée ES,de Ridder CMA,Gibson A,Stuurman D,Aghai A,Erkens-Schulze S,Mathijssen RHJ,Sparreboom A,de Wit R,Lolkema MP,van Weerden WM

    更新日期：2020-12-01 00:00:00

  • Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status.

    abstract：:Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.241

    authors： Masson P,Pålsson B,Andrén-Sandberg A

    更新日期：1990-07-01 00:00:00

  • Breast density and outcome of mammography screening: a cohort study.

    abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604989

    authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

    更新日期：2009-04-07 00:00:00

  • The opposing roles of Wnt-5a in cancer.

    abstract：:Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to tr...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6605174

    authors： McDonald SL,Silver A

    更新日期：2009-07-21 00:00:00

  • Molecular alterations associated with liver metastases development in colorectal cancer patients.

    abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.184

    authors： Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJ

    更新日期：2011-07-12 00:00:00

  • A quantitative morphological analysis of the response of a transplantable rat fibrosarcoma to cyclophosphamide.

    abstract：:The response of a transplantable rat fibrosarcoma, RIB(5), to a single injection of 100 mg/kg body weight of cyclophosphamide, 0·5, 1, 2 and 3 days after treatment, has been studied by means of a morphometric analysis of tumour sections and has been compared to the changes occurring in untreated tumours. The results s...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.9

    authors： Peel S,Cowen DM

    更新日期：1973-01-01 00:00:00

  • Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer.

    abstract：:Monocyte-macrophage series have an important role in host surveillance against cancer. The cytotoxic/cytostatic activity of macrophages is, to a great extent, attributed to the up-regulation of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Here, in 28 patients with primary lung cancer and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.528

    authors： Liu CY,Wang CH,Chen TC,Lin HC,Yu CT,Kuo HP

    更新日期：1998-08-01 00:00:00

  • The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468.

    abstract：:Using the breast carcinoma cell line MDA-MB 468 as immunogen, we have produced six new rat monoclonal antibodies (mAbs) against the human EGF receptor (EGFR) and are investigating their use for diagnostic and therapeutic applications in cancer patients whose tumours overexpress these receptors. The mAbs (three IgG2b a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.48

    authors： Modjtahedi H,Styles JM,Dean CJ

    更新日期：1993-02-01 00:00:00

  • Comparison of nuclear texture analysis and image cytometric DNA analysis for the assessment of dysplasia in Barrett's oesophagus.

    abstract：BACKGROUND:Dysplasia is a marker of cancer risk in Barrett's oesophagus (BO), but this risk is variable and diagnosis is subject to inter-observer variability. Cancer risk in BO is increased when chromosomal instability is present. Nucleotyping (NT) is a new method that uses high-resolution digital images of nuclei to ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.353

    authors： Dunn JM,Hveem T,Pretorius M,Oukrif D,Nielsen B,Albregtsen F,Lovat LB,Novelli MR,Danielsen HE

    更新日期：2011-10-11 00:00:00

  • A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.

    abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1982.138

    authors： Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

    更新日期：1982-06-01 00:00:00

  • Pyridinium crosslinks as markers of bone resorption in patients with breast cancer.

    abstract：:Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastas...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1991.419

    authors： Paterson CR,Robins SP,Horobin JM,Preece PE,Cuschieri A

    更新日期：1991-11-01 00:00:00

  • Detailed cytogenetic study of a metastatic bronchial carcinoma.

    abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1976.162

    authors： Pickthall VJ

    更新日期：1976-09-01 00:00:00

  • Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial).

    abstract：BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01222-8

    authors： Ueno H,Ishiguro M,Nakatani E,Ishikawa T,Uetake H,Murotani K,Matsui S,Teramukai S,Sugai T,Ajioka Y,Maruo H,Kotaka M,Tsujie M,Munemoto Y,Yamaguchi T,Kuroda H,Fukunaga M,Tomita N,Sugihara K

    更新日期：2021-01-07 00:00:00

  • Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion.

    abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.438

    authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

    更新日期：2014-09-09 00:00:00

  • CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis.

    abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0779-9

    authors： Qin B,Zou S,Li K,Wang H,Wei W,Zhang B,Xiao L,Choi HH,Tang Q,Huang D,Liu Q,Pan Q,Meng M,Fang L,Lee MH

    更新日期：2020-05-01 00:00:00

  • CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.

    abstract：:The cytochrome P450 CYP1B1 is consistently overexpressed in tumour cells as compared to their normal counterparts, but its precise role in drug resistance is yet to be defined. It has been reported that transfection of CYP1B1 results in increased resistance to docetaxel in V79 cells (McFadyen et al, 2001). In this stu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604195

    authors： Martinez VG,O'Connor R,Liang Y,Clynes M

    更新日期：2008-02-12 00:00:00

  • Tumour-marker levels and prognosis in malignant teratoma of the testis.

    abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1980.332

    authors： Germa-Lluch JR,Begent RH,Bagshawe KD

    更新日期：1980-12-01 00:00:00