Quantification of the role of smoking and chewing tobacco in oral, pharyngeal, and oesophageal cancers.

abstract：BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC...

journal_title：British journal of cancer

authors： Takahashi Y,Sawada G,Kurashige J,Uchi R,Matsumura T,Ueo H,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Doki Y,Mori M,Mimori K

更新日期：2013-07-23 00:00:00

abstract：:A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m(2)3-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial...

journal_title：British journal of cancer

authors： Gridelli C,Manzione L,Perrone F,Veltri E,Cioffi R,Caprio MG,Frontini L,Rossi A,Barletta E,Barzelloni ML,Bilancia D,Gallo C

更新日期：2001-01-05 00:00:00

abstract：BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...

journal_title：British journal of cancer

authors： Po'uha ST,Le Grand M,Brandl MB,Gifford AJ,Goodall GJ,Khew-Goodall Y,Kavallaris M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...

journal_title：British journal of cancer

authors： van Schoor G,Moss SM,Otten JD,Donders R,Paap E,den Heeten GJ,Holland R,Broeders MJ,Verbeek AL

更新日期：2011-03-15 00:00:00

abstract：:Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the ge...

journal_title：British journal of cancer

authors： Soeripto,Jensen OM,Muir CS

更新日期：1977-07-01 00:00:00

abstract：:We have previously reported that interleukin 10 (IL-10) signalling stimulated activation of a specific enhancer element, termed HTE-1, to promote tissue inhibitor of matrix metalloproteinase1 (TIMP-1) expression in human bone metastatic PC-3 subclone (PC-3 ML) cells. Recently, we have identified an IL-10 responsive si...

journal_title：British journal of cancer

authors： Wang M,Hu Y,Stearns ME

更新日期：2003-05-19 00:00:00

abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...

journal_title：British journal of cancer

authors： Wang W,Chen H,Liu Z,Qu P,Lan J,Chen H,Zou L,Qiu J

更新日期：2016-02-02 00:00:00

abstract：:The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean a...

journal_title：British journal of cancer

authors： Dowsett M,Harris AL,Stuart-Harris R,Hill M,Cantwell BM,Smith IE,Jeffcoate SL

更新日期：1985-10-01 00:00:00

abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1997-01-01 00:00:00

abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

journal_title：British journal of cancer

authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

更新日期：1994-03-01 00:00:00

abstract：:Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy. Many prognostic factors have been identified often based on retrospective, underpowered studies with unclear analyses. ...

journal_title：British journal of cancer

authors： Stocken DD,Hassan AB,Altman DG,Billingham LJ,Bramhall SR,Johnson PJ,Freemantle N

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Evasion of apoptosis contributes to the pathogenesis of solid tumours including non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). METHODS:A phenylurea-based small molecule inhibitor of XIAP, XI...

journal_title：British journal of cancer

authors： Dean EJ,Ward T,Pinilla C,Houghten R,Welsh K,Makin G,Ranson M,Dive C

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Period analysis is increasingly used to compute long-term cancer survival, as it provides better prediction of survival of newly diagnosed patients than traditional cohort analysis. However, the patient population to which period survival estimates best pertain to and which should be described in a study is ...

journal_title：British journal of cancer

authors： Jansen L,Hakulinen T,Brenner H

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

journal_title：British journal of cancer

authors： Leber TM,Balkwill FR

更新日期：1998-09-01 00:00:00

abstract：:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...

journal_title：British journal of cancer

authors： Mattern J,Bak M Jr,Hoever KH,Volm M

更新日期：1988-07-01 00:00:00

abstract：:High-throughput microarrays are being used in expression profiling analyses with the objectives of gene and pathway discovery, functional characterization of genes, and tumor subclassification. This review summarizes bladder cancer studies dealing with both in vitro models and clinical specimens, using distinct microa...

journal_title：British journal of cancer

authors： Sánchez-Carbayo M,Cordon-Cardo C

更新日期：2003-12-15 00:00:00

abstract：:Within a population-based cohort study, 40,708 men aged 45-79 years followed from 1998 to 2004. After adjusting for potential confounders, we observed a strong inverse linear association between total daily physical activity (PA) and death from cancer (n=1153). For each increment of 4 metabolic equivalent (MET)-h day(...

journal_title：British journal of cancer

authors： Orsini N,Mantzoros CS,Wolk A

更新日期：2008-06-03 00:00:00

abstract：:The zinc finger protein glioma-associated oncogene homologue 1 (Gli-1) is a critical component of the Hedgehog (Hh) signalling pathway, which is essential for morphogenesis and stem-cell renewal, and is dysregulated in many cancer types. As data were not available on the role of Gli-1 expression in oesophageal cancer ...

journal_title：British journal of cancer

authors： Yoshikawa R,Nakano Y,Tao L,Koishi K,Matsumoto T,Sasako M,Tsujimura T,Hashimoto-Tamaoki T,Fujiwara Y

更新日期：2008-05-20 00:00:00

abstract：:I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of...

journal_title：British journal of cancer

authors： Conroy PJ,Von Burg R,Penney DP,Passalacqua W,Sutherland RM

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：:Urethane was found to be uniformly distributed in all the major organs of foetal, young and adult ICR/Jcl mice and then to disappear rapidly as measured by the incorporation of urethane-carbonyl-14C, thus permitting the accurate comparison of tumour susceptibility of cells in various organs of mice at different ages. ...

journal_title：British journal of cancer

authors： Nomura T

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. METHODS:Data on age c...

journal_title：British journal of cancer

authors： Brustugun OT,Møller B,Helland A

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:It has been reported that although young patients present with more advanced disease, when adjusted for stage, cancer-specific survival is not different after surgery for colorectal cancer. However, few studies have examined non-cancer survival in young patients and 10-year survival has rarely been reported....

journal_title：British journal of cancer

authors： McMillan DC,McArdle CS

更新日期：2009-08-18 00:00:00

abstract：:We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...

journal_title：British journal of cancer

authors： Nawa G,Miyoshi Y,Yoshikawa H,Ochi T,Nakamura Y

更新日期：1999-06-01 00:00:00

abstract：:The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45(neg) myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45(neg) Myeloma p...

journal_title：British journal of cancer

authors： Descamps G,Gomez-Bougie P,Venot C,Moreau P,Bataille R,Amiot M

更新日期：2009-01-27 00:00:00

abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

journal_title：British journal of cancer

authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...

journal_title：British journal of cancer

authors： Yang Z,Wang XL,Bai R,Liu WY,Li X,Liu M,Tang H

更新日期：2016-09-06 00:00:00

abstract：:Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This st...

journal_title：British journal of cancer

authors： De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli G

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the associat...

journal_title：British journal of cancer

authors： Quinn DI,Stricker PD,Kench JG,Grogan J,Haynes AM,Henshall SM,Grygiel JJ,Delprado W,Turner JJ,Horvath LG,Mahon KL

更新日期：2019-10-01 00:00:00