A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells.

abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

journal_title：British journal of cancer

authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

更新日期：2021-01-21 00:00:00

abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...

journal_title：British journal of cancer

authors： Baeuerle PA,Gires O

更新日期：2007-02-12 00:00:00

abstract：:HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...

journal_title：British journal of cancer

authors： Tanaka H,Tsunoda T,Nukaya I,Sette A,Matsuda K,Umano Y,Yamaue H,Takesako K,Tanimura H

更新日期：2001-01-05 00:00:00

abstract：:The 62 kDa protein product of the c-myc oncogene (p62 c-myc) is thought to be involved in the control of normal cellular proliferation and differentiation. We have measured oncoprotein levels using a flow cytometric assay in 141 operable breast cancers and have correlated levels with prognostic variables, patient surv...

journal_title：British journal of cancer

authors： Locker AP,Dowle CS,Ellis IO,Elston CW,Blamey RW,Sikora K,Evan G,Robins RA

更新日期：1989-11-01 00:00:00

abstract：:NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of the NQO2 homologue NQO1. NRH:quinone oxidoreductase 2 catalysed the r...

journal_title：British journal of cancer

authors： Jamieson D,Tung AT,Knox RJ,Boddy AV

更新日期：2006-11-06 00:00:00

abstract：:Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...

journal_title：British journal of cancer

authors： Dworkin MJ,Carnochan P,Allen-Mersh TG

更新日期：1997-01-01 00:00:00

abstract：:Several radiotherapeutic schedules compatible with continued structural-functional integrity of the gastrointestinal (GI) mucosa were compared utilizing the P815X2 murine mastocytoma grown as a solid subcutaneous tumour. Both the tumour and underlying normal tissues were irradiated during the treatments. The tumour ex...

journal_title：British journal of cancer

authors： Schenken LL,Poulakos L,Hagemann RF

更新日期：1975-02-01 00:00:00

abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...

journal_title：British journal of cancer

authors： Abid SH,Khoobyarian N

更新日期：1976-04-01 00:00:00

abstract：:We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...

journal_title：British journal of cancer

authors： Nawa G,Miyoshi Y,Yoshikawa H,Ochi T,Nakamura Y

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...

journal_title：British journal of cancer

authors： Dashti SG,Li WY,Buchanan DD,Clendenning M,Rosty C,Winship IM,Macrae FA,Giles GG,Hardikar S,Hua X,Thibodeau SN,Figueiredo JC,Casey G,Haile RW,Gallinger S,Le Marchand L,Newcomb PA,Potter JD,Lindor NM,Hopper JL,Jenki

更新日期：2019-11-01 00:00:00

abstract：:Oxygen is an essential regulator of cellular metabolism, survival, and proliferation. Cellular responses to oxygen levels are monitored, in part, by the transcriptional activity of the hypoxia inducible factors (HIFs). Under hypoxia, HIFs regulate a variety of pro-angiogenic and pro-glycolysis pathways. In solid cance...

journal_title：British journal of cancer

authors： Heddleston JM,Li Z,Lathia JD,Bao S,Hjelmeland AB,Rich JN

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the associat...

journal_title：British journal of cancer

authors： Quinn DI,Stricker PD,Kench JG,Grogan J,Haynes AM,Henshall SM,Grygiel JJ,Delprado W,Turner JJ,Horvath LG,Mahon KL

更新日期：2019-10-01 00:00:00

abstract：:This randomised trial compared platinum-based to anthracycline-based chemotherapy in patients with small-cell lung cancer (limited or extensive stage) and

journal_title：British journal of cancer

authors： Baka S,Califano R,Ferraldeschi R,Aschroft L,Thatcher N,Taylor P,Faivre-Finn C,Blackhall F,Lorigan P

更新日期：2008-08-05 00:00:00

abstract：:The interaction between laminin and the oncoprotein encoded by the c-erbB-2 oncogene was studied in vitro and in vivo in human breast carcinomas. In vitro analysis of breast carcinoma cell lines overexpressing p185HER2 revealed that laminin, but not fibronectin, induced tyrosine phosphorylation and down-modulation of ...

journal_title：British journal of cancer

authors： Tagliabue E,Ardini E,Pellegrini R,Campiglio M,Bufalino R,Jeschke M,Groner B,Colnaghi MI,Ménard S

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

journal_title：British journal of cancer

authors： Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

更新日期：2014-05-27 00:00:00

abstract：:Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suita...

journal_title：British journal of cancer

authors： Elsheikh SE,Green AR,Rakha EA,Samaka RM,Ammar AA,Powe D,Reis-Filho JS,Ellis IO

更新日期：2008-07-22 00:00:00

abstract：:Platinum diamine dichloride and tetrachloride inhibit the formation of antibody-forming cells in the mouse spleen after injection of sheep red cells. The dichloride is the more effective agent. It acts best when given 2 days after the antigen, which suggests that cells are more sensitive to its action when they are ra...

journal_title：British journal of cancer

authors： Berenbaum MC

更新日期：1971-03-01 00:00:00

abstract：:As part of an NHS Executive Trent regional initiative we considered the role and cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma. The key trials and case series show an additional patient benefit of 0.8-1.1 life years over standard chemotherapy. We...

journal_title：British journal of cancer

authors： Beard SM,Lorigan PC,Sampson FC

更新日期：2000-01-01 00:00:00

abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

journal_title：British journal of cancer

authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

更新日期：1998-09-01 00:00:00

abstract：:Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of ...

journal_title：British journal of cancer

authors： Seufferlein T,Seckl MJ,Schwarz E,Beil M,v Wichert G,Baust H,Lührs H,Schmid RM,Adler G

更新日期：2002-04-08 00:00:00

abstract：:To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...

journal_title：British journal of cancer

authors： Panahy C,Puddefoot JR,Anderson E,Vinson GP,Berry CL,Turner MJ,Brown CL,Goode AW

更新日期：1987-04-01 00:00:00

abstract：:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attend...

journal_title：British journal of cancer

authors： Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

更新日期：1996-08-01 00:00:00

abstract：:The reaction patterns of eight antibodies directed against blood group substances A, B and H, respectively, against Lewis B antigen, difucosylated carbohydrate antigens (DFCA), gastrointestinal cancer antigen CA 19-9 (GICA), carcinoma-associated antigen CA-50 and CEA, were studied in 68 rectal carcinomas using the avi...

journal_title：British journal of cancer

authors： Enblad P,Glimelius B,Busch C,Pontén J,Påhlman L

更新日期：1987-05-01 00:00:00

abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...

journal_title：British journal of cancer

authors： Couteau C,Chouaki N,Leyvraz S,Oulid-Aissa D,Lebecq A,Domenge C,Groult V,Bordessoule S,Janot F,De Forni M,Armand JP

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...

journal_title：British journal of cancer

authors： Alì G,Boldrini L,Lucchi M,Picchi A,Dell'Omodarme M,Prati MC,Mussi A,Corsi V,Fontanini G

更新日期：2009-12-01 00:00:00

abstract：:In the family reported here, a mother and both of her children developed a Wilms tumour, and all three tumours were of the relatively rare monomorphous epithelial histopathological subtype. Using restriction fragment length polymorphism analysis, both sibs were shown to inherit the same maternal allele from the 11p13 ...

journal_title：British journal of cancer

authors： Baird PN,Pritchard J,Cowell JK

更新日期：1994-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Gkotzamanidou M,Sfikakis PP,Kyrtopoulos SA,Bamia C,Dimopoulos MA,Souliotis VL

更新日期：2020-05-01 00:00:00

abstract：:In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...

journal_title：British journal of cancer

authors： Bracarda S,Porta C,Sisani M,Marrocolo F,Paglino C,Hamzaj A,D Buono S,Sternberg CN

更新日期：2015-01-06 00:00:00

abstract：:The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...

journal_title：British journal of cancer

authors： Hsieh LL,Huang TH,Chen IH,Liao CT,Wang HM,Lai CH,Liou SH,Chang JT,Cheng AJ

更新日期：2005-01-17 00:00:00