Abstract：
:The reaction patterns of eight antibodies directed against blood group substances A, B and H, respectively, against Lewis B antigen, difucosylated carbohydrate antigens (DFCA), gastrointestinal cancer antigen CA 19-9 (GICA), carcinoma-associated antigen CA-50 and CEA, were studied in 68 rectal carcinomas using the avidin-biotin-peroxidase method. A pronounced intratumoral antigenic heterogeneity was revealed for most antigens. It thus became evident that an interpretation based upon small preoperative biopsies would be inaccurate. The overall proportion of positive carcinoma cells, however, did not vary much between larger samples taken postoperatively from different regions of the tumours. The intertumoral antigenic variability was also considerable: nearly all tumours had an individual immunohistochemical profile according to the proportions of positive cells. Heterogeneous staining patterns were also present within metastases, and lymph node metastases from the primary tumour in some cases differed completely from each other. The staining pattern did not correlate with Dukes' stage, and degree of differentiation; the expression of any individual antigen, or several antigens in combination.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Enblad P,Glimelius B,Busch C,Pontén J,Påhlman Ldoi
10.1038/bjc.1987.102subject
Has Abstractpub_date
1987-05-01 00:00:00pages
503-8issue
5eissn
0007-0920issn
1532-1827journal_volume
55pub_type
杂志文章abstract：:A mini-review of the literature concerning epigenetic gene regulation in cancer. ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1054/bjoc.2000.1549
更新日期：2000-12-01 00:00:00
abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604989
更新日期：2009-04-07 00:00:00
abstract：:There is considerable interest in immunohistochemical markers of proliferation which are suitable for use on routinely fixed clinical material. The novel proliferation-associated antibody Ki-S1 shows promise in this respect. In this study we have: (i) defined the pattern of Ki-S1 labelling relative to the cell cycle p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.122
更新日期：1993-04-01 00:00:00
abstract：:Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602048
更新日期：2004-08-16 00:00:00
abstract：:Apurinic/apyrimidinic (AP) sites in DNA are potentially lethal and mutagenic. They can arise spontaneously or following DNA damage from reactive oxygen species or alkylating agents, and they constitute a significant product of DNA damage following cellular exposure to ionizing radiation. The major AP endonuclease resp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690447
更新日期：1999-06-01 00:00:00
abstract：:The normal epithelial cell-specific 1 (NES1) gene (official name kallikrein gene 10; KLK10) is a new member of the expanding human kallikrein gene family and encodes for a secreted serine protease. Experimental evidence suggests that NES1 controls normal cell growth and may function as a tumour suppressor. NES1 is dow...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1870
更新日期：2001-07-20 00:00:00
abstract：:Raltitrexed, a thymidylate synthase inhibitor, was given to 21 patients with advanced small-cell lung cancer, at a dose of 3 mg m(-2) as a 15-min intravenous infusion at 21-day intervals. All of the patients had extensive disease and 17 had received prior therapy. Patients with disease refractory to primary chemothera...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1997.373
更新日期：1997-01-01 00:00:00
abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602392
更新日期：2005-04-11 00:00:00
abstract：BACKGROUND:OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as embryonal carcinoma. OCT3/4 is crucial for the regulation of pluripot...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.270
更新日期：2011-09-06 00:00:00
abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604621
更新日期：2008-09-16 00:00:00
abstract：BACKGROUND:A combination of S-1 and cisplatin has been shown to be effective with acceptable safety for the first-line treatment of far-advanced gastric cancer in Japan. This is the first randomised phase II trial to compare S-1+paclitaxel with S-1+cisplatin in this setting. METHODS:Patients with unresectable and/or r...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2012.222
更新日期：2012-06-26 00:00:00
abstract：:The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the retinoblastoma protein (pRB), on the radiation response in bladder cancer. In order to obtain a truly objective response measure, patient...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601063
更新日期：2003-07-21 00:00:00
abstract：:We evaluated the risk of bladder cancer in a cohort of 79,280 Swedish men hospitalised for benign prostatic hyperplasia (BPH), identified in the Swedish Inpatient Register between 1964 and 1983 and followed until 1989 via multiple record linkages with nationwide data on cancer registry, death and emigration. Standardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603730
更新日期：2007-05-07 00:00:00
abstract：:In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse here data on haemoglobin adducts of 14 aromatic amines in order to ascertain if the inter-individual variability left unexp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.120
更新日期：1990-04-01 00:00:00
abstract：:Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603819
更新日期：2007-06-18 00:00:00
abstract：:This study was planned to evaluate the feasibility of mouth self-examination (MSE). Some 450 college students distributed to 9000 households a brochure describing the risk factors of oral cancer, the appearance of premalignant and malignant lesions of the oral cavity and the methods of MSE with pictures. All subjects ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.1995.81
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epidemiology studies, such as studies of disease prognosis. However, TMA data are particularly prone to missingness. A variety of methods to deal with missing data are available. However, the v...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6606078
更新日期：2011-02-15 00:00:00
abstract：BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.188
更新日期：2013-05-28 00:00:00
abstract：:The combination of heat and chemotherapy was studied in an intraperitoneal tumour model. Rats bearing peritoneal CC531 tumours (2-6 mm) were treated i.p. with cDDP or CBDCA [maximal tolerated dose (MTD)] in combination with regional hyperthermia (41.5 degrees C, 1 h) of the peritoneal cavity. The addition of hyperther...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.45
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/bjc.2015.342
更新日期：2015-11-03 00:00:00
abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1900
更新日期：2001-08-03 00:00:00
abstract：:Germline anomalies of the INK4a-ARF and Cdk4 genes were sought in a series of 89 patients suspected of having a genetic predisposition to melanoma. Patients were selected based on the following criteria: (a) familial melanoma (23 cases), (b) multiple primary melanoma (MPM; 18 cases), (c) melanoma and additional unrela...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601503
更新日期：2004-01-26 00:00:00
abstract：:The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690088
更新日期：1999-02-01 00:00:00
abstract：:The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in the treatment of advanced colorectal carcinoma. Laboratory studies of IFN-beta suggest that this agent may offer theoretical advantages over IFN-alpha in combination with 5-FU. A total of 27 patients with advanced or rec...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1997.69
更新日期：1997-01-01 00:00:00
abstract：:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.255
更新日期：1981-11-01 00:00:00
abstract：:In spite of the wide range of tumours successfully treated with 5-aminolevulinic acid mediated photodynamic therapy, the fact that 5-aminolevulinic acid has low lipid solubility, limits its clinical application. More lipophilic 5-aminolevulinic acid prodrugs and the use of liposomal carriers are two approaches aimed a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600144
更新日期：2002-03-04 00:00:00
abstract：:Perforin (PFP) is a cytotoxic protein released from killer cells. PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody. PFP was detected in the cytoplasm of 10% of PBL. We perform...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.283
更新日期：1991-08-01 00:00:00
abstract：:In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.258
更新日期：1991-07-01 00:00:00
abstract：:Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1628
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.341
更新日期：2017-12-05 00:00:00
