Abstract：
:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected information for the years 1991-2001 on screening outcome, incident BCs (screen-, interval-, and later detected), and BC deaths. Breast density was dichotomised into fatty (F) and mixed/dense (M/D) breasts. Screening sensitivity was measured as the odds ratio of interval versus screen-detected cancer for dense versus F breasts. Poisson regression was used to estimate the ratios for BC incidence, case fatality, and mortality between women with M/D and F breasts. For women with M/D breasts, the odds ratio of an interval cancer was 1.62 (95% confidence interval, CI, 1.14-2.30), and the age-adjusted rate ratios were 2.45 (95% CI 2.14-2.81) for BC incidence, 0.60 (95% CI 0.43-0.84) for case fatality, and 1.78 (95% CI 1.17-2.72) for BC mortality. The study shows that BC in women with M/D breasts is more frequent, but on average less severe, than in women with F breasts.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge Edoi
10.1038/sj.bjc.6604989subject
Has Abstractpub_date
2009-04-07 00:00:00pages
1205-8issue
7eissn
0007-0920issn
1532-1827pii
6604989journal_volume
100pub_type
杂志文章abstract：:Photodynamic therapy (PDT) is a form of cancer treatment based on the destruction of cells by the interaction of light, oxygen and a photosensitizer. Aminolaevulinic acid (ALA) is the prodrug of the photosensitizer protoporphyrin IX (PpIX). ALA-induced PDT depends on the rate of cellular synthesis of PpIX, which may v...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.441
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.129
更新日期：2012-05-08 00:00:00
abstract：:Circulating serum factors have been said to abrogate the effects of immune response in cancer, i.e. "blocking" and "antigenic inhibition". The aim of this investigation was to isolate such specific factors in a purified and native state. F(ab)2 fragments isolated from hypernephroma were insolubilized on the surfaces o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.279
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epith...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605544
更新日期：2010-03-02 00:00:00
abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1997.127
更新日期：1997-01-01 00:00:00
abstract：:To evaluate whether green tea consumption provides protection against stomach cancer death, relative risks were calculated using Cox proportional hazards regression analysis in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600487
更新日期：2002-07-29 00:00:00
abstract：:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600326
更新日期：2002-06-17 00:00:00
abstract：:Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.302
更新日期：1988-12-01 00:00:00
abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1998.393
更新日期：1998-06-01 00:00:00
abstract：:Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.126
更新日期：1987-06-01 00:00:00
abstract：:We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated patients with ovarian cancer. These cells may be used to provide safe and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.637
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20-30% of patients. Drug repurposing for anti-cancer treatments is gaining momentum, but the potential...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2017.175
更新日期：2017-07-11 00:00:00
abstract：:Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602048
更新日期：2004-08-16 00:00:00
abstract：:It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells has not been fully elucidated. The present study was undertaken to characterise an activator of latent TGF-beta 1 secrete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.393
更新日期：1995-09-01 00:00:00
abstract：:Human peripheral-blood mononuclear cells, separated by Isopaque-Ficoll flotation and E-rosette formation, were tested by the fluorescein fluorescence polarization method of Cercek & Cercek (the SCM test). The response to stimulation with PHA or cancer tissue leads to a decreased polarization value TP). The responding ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.228
更新日期：1979-10-01 00:00:00
abstract：:The establishment and characterisation (morphology, ultrastructure, tumourigenicity) of six cell lines from primary human colorectal adenocarcinomas is described. These lines were established from surgical specimens, from 49 unselected patients, without the use of 'feeder' cells, 'conditioned' medium or passage of cel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.132
更新日期：1986-06-01 00:00:00
abstract：:Local infiltrates of eosinophilic leucocytes and macrophages and the deposition of acid mucopolysaccharides (AMPS) in 72 operable primary lung cancers and 17 isolated pulmonary metastases of known origin were correlated to tumour stage (radically or non-radically operable) and clinical course, by following the patient...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.196
更新日期：1979-09-01 00:00:00
abstract：:HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605084
更新日期：2009-06-16 00:00:00
abstract：:One hundred cancer patients undergoing active treatment were interviewed to determine how they perceived their illness and how their perceptions compared with those of their attending physicians. Ninety-eight patients recognized that they had cancer and 87 correctly identified the tumour type. Sixty-four of 67 patient...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.218
更新日期：1988-09-01 00:00:00
abstract：:The WWOX (WW-domain containing oxidoreductase) is a candidate tumour suppressor gene spanning the same chromosome region, 16q23, as the second most common fragile site (FS), FRA16D. Deletions detected by comparative genomic hybridisation (CGH) and loss of heterozygosity at microsatellite markers on chromosome 16q are ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602023
更新日期：2004-08-16 00:00:00
abstract：:This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearrange...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.279
更新日期：1997-01-01 00:00:00
abstract：:Lysophosphatidic acid (LPA) is a potent lipid mediator that acts on a series of specific G protein-coupled receptors, leading to diverse biological actions. Lysophosphatidic acid induces cell proliferation, survival and migration, which are critically required for tumour formation and metastasis. This bioactive lipid ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605588
更新日期：2010-03-16 00:00:00
abstract：:A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for phase I clinical trials due to commence in 1997. AMD473 was rationally designed to react preferentially with nucleic acids over sulphur ligands such as glutathione. This report documents the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.59
更新日期：1998-01-01 00:00:00
abstract：:The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo. Cells grown in the presence of increasing concentrations of DX and of 1 microM VRP, tested at several passages, were more resistant than...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.79
更新日期：1988-04-01 00:00:00
abstract：:Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603824
更新日期：2007-06-18 00:00:00
abstract：:The tumour vasculature is vital for the establishment, growth and metastasis of solid tumours. Its physiological properties limit the effectiveness of conventional anti-cancer strategies. Therapeutic approaches directed at the tumour vasculature are reviewed, suggesting the potential of anti-angiogenesis and the targe...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1995.323
更新日期：1995-08-01 00:00:00
abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.242
更新日期：1992-07-01 00:00:00
abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.340
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the associat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0549-8
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Current international guidelines recommend the use of platinum-based chemotherapy with thoracic radiotherapy (TRT) for patients with locally advanced non-small-cell lung cancer (NSCLC). METHODS:Patients with unresectable stage IIIA or IIIB NSCLC were treated with nedaplatin (NP) at 50 mg m(-2) and irinoteca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605875
更新日期：2010-10-26 00:00:00
