Tumour vasculature--a potential therapeutic target.

abstract：:The RNASEL gene on chromosome 1q25 has been identified as a prostate cancer susceptibility gene. We screened for RNASEL germline mutations in familial prostate cancer patients, and performed a case-control study to examine the association of specific variants with prostate cancer risk in the Japanese. Three variants w...

journal_title：British journal of cancer

authors： Nakazato H,Suzuki K,Matsui H,Ohtake N,Nakata S,Yamanaka H

更新日期：2003-08-18 00:00:00

abstract：:We investigated whether dietary intakes of total fat, monounsaturated fat (MUFA), polyunsaturated fat (PUFA) and saturated fat (SFA) were associated with breast cancer risk in a prospective cohort of 49 261 Swedish women (30-49 years at enrolment), which yielded 974 breast cancer cases by December 2005. Further, we ev...

journal_title：British journal of cancer

authors： Löf M,Sandin S,Lagiou P,Hilakivi-Clarke L,Trichopoulos D,Adami HO,Weiderpass E

更新日期：2007-12-03 00:00:00

abstract：BACKGROUND:Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises f...

journal_title：British journal of cancer

authors： Jones CI,Zabolotskaya MV,King AJ,Stewart HJ,Horne GA,Chevassut TJ,Newbury SF

更新日期：2012-12-04 00:00:00

abstract：:Neurofilaments (NFs) are specific intermediate filaments to neural cells. Mammalian NFs are protein triplets composed of three major subunits with respective molecular weights of approximately 70, 150 and 200 kD. Using an immunohistochemical method, 13 carcinoid tumours from different sites were examined for the prese...

journal_title：British journal of cancer

authors： Astarloa R,Sánchez-Franco F,Cacicedo L,García-Villanueva M

更新日期：1991-05-01 00:00:00

abstract：:The survival of 64 consecutive patients with disseminated midgut carcinoid tumours was compared in a retrospective study with that of 25 consecutive patients with sporadic malignant endocrine pancreatic tumours treated according to similar surgical principles. The presence of hepatic metastases implied a worse prognos...

journal_title：British journal of cancer

authors： Johanson V,Tisell LE,Olbe L,Wängberg B,Nilsson O,Ahlman H

更新日期：1999-06-01 00:00:00

abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

journal_title：British journal of cancer

authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

更新日期：1996-02-01 00:00:00

abstract：:The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...

journal_title：British journal of cancer

authors： Thomas GJ,Hart IR,Speight PM,Marshall JF

更新日期：2002-10-07 00:00:00

abstract：:The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immun...

journal_title：British journal of cancer

authors： Stirpe F,Wawrzynczak EJ,Brown AN,Knyba RE,Watson GJ,Barbieri L,Thorpe PE

更新日期：1988-11-01 00:00:00

abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...

journal_title：British journal of cancer

authors： Collet JF,Hurbain I,Prengel C,Utzmann O,Scetbon F,Bernaudin JF,Fajac A

更新日期：2005-11-14 00:00:00

abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

journal_title：British journal of cancer

authors： Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

更新日期：2019-03-01 00:00:00

abstract：:The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional...

journal_title：British journal of cancer

authors： Andersson SW,Bengtsson C,Hallberg L,Lapidus L,Niklasson A,Wallgren A,Hulthén L

更新日期：2001-05-04 00:00:00

abstract：:Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We report lymphocytic DPD data concerning a group of 53 patients (23 men, 30 women, mean age 58, range 36-73), treated by 5-FU-based chemotherapy in different French institutions and who developed unantic...

journal_title：British journal of cancer

authors： Milano G,Etienne MC,Pierrefite V,Barberi-Heyob M,Deporte-Fety R,Renée N

更新日期：1999-02-01 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...

journal_title：British journal of cancer

authors： Sidebottom E,Clark SR

更新日期：1983-03-01 00:00:00

abstract：:Time trends in therapeutic approaches and in the prognosis of colon cancer for patients aged 75 years and above have been investigated in comparison with corresponding trends for younger patients using a population-based series of 2089 colon cancer patients diagnosed between 1976 and 1990 in the Côte-d'Or area (478,00...

journal_title：British journal of cancer

authors： Arveux I,Boutron MC,El Mrini T,Arveux P,Liabeuf A,Pfitzenmeyer P,Faivre J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

journal_title：British journal of cancer

authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

更新日期：2017-01-17 00:00:00

abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...

journal_title：British journal of cancer

authors： Fjeld JG,Benestad HB,Stigbrand T,Nustad K

更新日期：1992-07-01 00:00:00

abstract：:In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...

journal_title：British journal of cancer

authors： Iles S,Gollins S,Susnerwala S,Haylock B,Myint S,Biswas A,Swindell R,Levine E

更新日期：2008-04-08 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...

journal_title：British journal of cancer

authors： Pavlenko M,Roos AK,Lundqvist A,Palmborg A,Miller AM,Ozenci V,Bergman B,Egevad L,Hellström M,Kiessling R,Masucci G,Wersäll P,Nilsson S,Pisa P

更新日期：2004-08-16 00:00:00

abstract：:Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...

journal_title：British journal of cancer

authors： Meier J,Coleman MS,Hutton JJ

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...

journal_title：British journal of cancer

authors： Basso M,Strippoli A,Orlandi A,Martini M,Calegari MA,Schinzari G,Di Salvatore M,Cenci T,Cassano A,Larocca LM,Barone C

更新日期：2013-01-15 00:00:00

abstract：:This paper illustrates the efficacy of DNA vaccination through electroporation in the prevention of oral transplantable carcinoma in Syrian hamsters. At 21 and 7 days before tumour challenge, 19 hamsters were vaccinated with plasmids coding for the extracellular and transmembrane domains of rat HER-2 receptor (EC-TM p...

journal_title：British journal of cancer

authors： Berta GN,Mognetti B,Spadaro M,Trione E,Amici A,Forni G,Di Carlo F,Cavallo F

更新日期：2005-11-28 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Comparative genomic hybridization (CGH) was used to detect copy number changes of DNA sequences in the Ewing family of tumours (ET). We analysed 20 samples from 17 patients. Fifteen tumours (75%) showed copy number changes. Gains of DNA sequences were much more frequent than losses, the majority of the gains affecting...

journal_title：British journal of cancer

authors： Armengol G,Tarkkanen M,Virolainen M,Forus A,Valle J,Böhling T,Asko-Seljavaara S,Blomqvist C,Elomaa I,Karaharju E,Kivioja AH,Siimes MA,Tukiainen E,Caballín MR,Myklebost O,Knuutila S

更新日期：1997-01-01 00:00:00

abstract：:Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...

journal_title：British journal of cancer

authors： Vaage J,Harlos JP

更新日期：1991-05-01 00:00:00

abstract：:The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...

journal_title：British journal of cancer

authors： Brenner H

更新日期：1995-08-01 00:00:00

abstract：:Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...

journal_title：British journal of cancer

authors： Gale DG,MacLennan IC

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years....

journal_title：British journal of cancer

authors： Cho A,Chang Y,Ahn J,Shin H,Ryu S

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...

journal_title：British journal of cancer

authors： Fløtten Ø,Grønberg BH,Bremnes R,Amundsen T,Sundstrøm S,Rolke H,Hornslien K,Wentzel-Larsen T,Aasebø U,von Plessen C

更新日期：2012-07-24 00:00:00

abstract：:Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of ...

journal_title：British journal of cancer

authors： Seufferlein T,Seckl MJ,Schwarz E,Beil M,v Wichert G,Baust H,Lührs H,Schmid RM,Adler G

更新日期：2002-04-08 00:00:00