Cigarette smoking and thyroid cancer risk: a cohort study.

Abstract:

BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. RESULTS:During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current smoking, pack-years, and thyroid cancer. After adjustment for confounders, adjusted hazard ratios (95% confidence intervals) for thyroid cancer comparing current and former smokers to never smokers were 0.58 (0.45-0.75) and 0.93 (0.73-1.18), respectively. After further adjustment for BMI and TSH as potential mediators, this association was slightly attenuated, but remained significant. For women, current smokers tended to have a lower risk of thyroid cancer, but this association did not reach statistical significance. CONCLUSIONS:In this cohort study, current smoking was associated with a decreased risk of incident thyroid cancer in men but not in women and this association was observed even after adjusting for TSH and BMI levels as potential mediators. Further mechanistic studies are needed to elucidate the possible effect of smoking on the pathogenesis of thyroid cancer development.

journal_name

Br J Cancer

authors

Cho A,Chang Y,Ahn J,Shin H,Ryu S

doi

10.1038/s41416-018-0224-5

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

638-645

issue

5

eissn

0007-0920

issn

1532-1827

pii

10.1038/s41416-018-0224-5

journal_volume

119

pub_type

杂志文章
  • A prospective study of urinary oestrogen excretion and breast cancer risk.

    abstract::To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.304

    authors: Key TJ,Wang DY,Brown JB,Hermon C,Allen DS,Moore JW,Bulbrook RD,Fentiman IS,Pike MC

    更新日期:1996-06-01 00:00:00

  • Phase I study of Carzelesin (U-80,244) given (4-weekly) by intravenous bolus schedule.

    abstract::Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min i.v. infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1-5) at one of nine dose levels: 24, 48, ...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.bjc.6690232

    authors: Awada A,Punt CJ,Piccart MJ,Van Tellingen O,Van Manen L,Kerger J,Groot Y,Wanders J,Verweij J,Wagener DJ

    更新日期:1999-03-01 00:00:00

  • The effect of MDR-1 gene expression on outcome in acute myeloblastic leukaemia.

    abstract::Resistance to cytotoxic agents may be encountered during the treatment of acute myeloblastic leukaemia (AML). P-glycoprotein encoded by the MDR-1 gene has been implicated as a potential drug resistance mechanism in leukaemic cells. In recent years, many data have been accrued concerning the expression of P-glycoprotei...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/bjc.1994.70

    authors: Holmes JA,West RR

    更新日期:1994-02-01 00:00:00

  • Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study.

    abstract:BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2011.114

    authors: Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

    更新日期:2011-04-26 00:00:00

  • Hormonal treatment of pancreatic carcinoma: a phase II study of LHRH agonist goserelin plus hydrocortisone.

    abstract::Eighteen consecutive patients with measurable locally advanced or metastatic pancreatic adenocarcinoma were treated with goserelin (Zoladex) 3.6 mg subcutaneously every 4 weeks. Hydrocortisone 20 milligrams twice daily was commenced with the second injection of goserelin. Objective tumour response was monitored by com...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/bjc.1993.69

    authors: Philip PA,Carmichael J,Tonkin K,Buamah PK,Britton J,Dowsett M,Harris AL

    更新日期:1993-02-01 00:00:00

  • The potential for oral combination chemotherapy of 5'-deoxy-5-fluorouridine, a 5-FU prodrug, and cyclophosphamide for metastatic breast cancer.

    abstract::Preclinical studies have demonstrated the synergistic anti-tumour activity of combination therapy with the oral cytostatics, 5'-deoxy-5-fluorouridine (5'-DFUR) and cyclophosphamide (CPA), in human breast cancer xenograft models. This study was performed to evaluate the efficacy and safety of this oral combination chem...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.bjc.6601350

    authors: Yoshimoto M,Tada K,Tokudome N,Kutomi G,Tanabe M,Goto T,Nishimura S,Makita M,Kasumi F

    更新日期:2003-11-03 00:00:00

  • Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study.

    abstract:METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605169

    authors: Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

    更新日期:2009-08-04 00:00:00

  • Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study.

    abstract::A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m(2)3-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1054/bjoc.2000.1541

    authors: Gridelli C,Manzione L,Perrone F,Veltri E,Cioffi R,Caprio MG,Frontini L,Rossi A,Barletta E,Barzelloni ML,Bilancia D,Gallo C

    更新日期:2001-01-05 00:00:00

  • An investigation of factors influencing serum NCA (non-specific cross-reacting antigen) level in patients with chronic myeloid leukaemia.

    abstract::The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1982.269

    authors: Frénoy N,Ben-Bunant M,Berruel C,Child JA,Gendron MC,Missett JL,Razafimahaleo E,Burtin P

    更新日期:1982-11-01 00:00:00

  • A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer.

    abstract::To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.2001.2037

    authors: Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda K

    更新日期:2001-09-28 00:00:00

  • Five years' experience with ChlVPP: effective low-toxicity combination chemotherapy for Hodgkin's disease.

    abstract::Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 91% for patients previously treated with radiotherapy and 55% for patients previously treated w...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1982.137

    authors: Dady PJ,McElwain TJ,Austin DE,Barrett A,Peckham MJ

    更新日期:1982-06-01 00:00:00

  • Reduction by anti-inflammatory corticosteroids of clonogenic growth of allogeneic tumour cells in normal and irradiated tissues of the rat.

    abstract::Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1974.84

    authors: Van Den Brenk HA,Kelly H,Orton C

    更新日期:1974-05-01 00:00:00

  • Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

    abstract::To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bjc.6601991

    authors: Verburg FA,Lips CJ,Lentjes EG,de Klerk JM

    更新日期:2004-07-19 00:00:00

  • Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: influence of growth kinetics, growth environment and DNA packaging.

    abstract::Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1993.97

    authors: Olive PL,Banáth JP,Evans HH

    更新日期:1993-03-01 00:00:00

  • Neuromuscular toxicities of paclitaxel 210 mg m(-2) by 3-hour infusion.

    abstract::We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.278

    authors: Kunitoh H,Saijo N,Furuse K,Noda K,Ogawa M

    更新日期:1998-05-01 00:00:00

  • Treatment with interleukin-2 in malignant pleural mesothelioma: immunological and angiogenetic assessment and prognostic impact.

    abstract:BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605438

    authors: Alì G,Boldrini L,Lucchi M,Picchi A,Dell'Omodarme M,Prati MC,Mussi A,Corsi V,Fontanini G

    更新日期:2009-12-01 00:00:00

  • Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph node metastasis.

    abstract::The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR) techniques. The expression of u-...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.588

    authors: Yoshino H,Endo Y,Watanabe Y,Sasaki T

    更新日期:1998-09-01 00:00:00

  • Irinotecan+5-fluorouracil with concomitant pre-operative radiotherapy in locally advanced non-resectable rectal cancer: a phase I/II study.

    abstract::In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604292

    authors: Iles S,Gollins S,Susnerwala S,Haylock B,Myint S,Biswas A,Swindell R,Levine E

    更新日期:2008-04-08 00:00:00

  • Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane.

    abstract::The effects of suramin, an inhibitor of growth factor mitogenic activity, were evaluated on basic fibroblast growth factor (bFGF)-induced proliferation of bovine aortic endothelial cells and on angiogenesis in the chorioallantoic membrane (CAM) of chick embryos. The role of bFGF gene expression in endothelial cell gro...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1993.457

    authors: Danesi R,Del Bianchi S,Soldani P,Campagni A,La Rocca RV,Myers CE,Paparelli A,Del Tacca M

    更新日期:1993-11-01 00:00:00

  • Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

    abstract::NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. We have previously characterized a homozygous point mutation in the BE human colon carcinoma cell line that leads...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1997.11

    authors: Traver RD,Siegel D,Beall HD,Phillips RM,Gibson NW,Franklin WA,Ross D

    更新日期:1997-01-01 00:00:00

  • Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.

    abstract::It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.23

    authors: Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

    更新日期:1998-01-01 00:00:00

  • Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice.

    abstract::BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1973.143

    authors: Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

    更新日期:1973-09-01 00:00:00

  • Childhood acute lymphoblastic leukaemia and indicators of early immune stimulation: the Estelle study (SFCE).

    abstract:BACKGROUND:Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure to infectious agents, normal delivery, and exposure to animals in early life) have been suggested to decrease the risk of childhood acute lymphoblastic leukaemia (ALL). METHODS:The national registry-based case-con...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2015.53

    authors: Ajrouche R,Rudant J,Orsi L,Petit A,Baruchel A,Lambilliotte A,Gambart M,Michel G,Bertrand Y,Ducassou S,Gandemer V,Paillard C,Saumet L,Blin N,Hémon D,Clavel J

    更新日期:2015-03-17 00:00:00

  • Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell priming.

    abstract::Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6602518

    authors: Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

    更新日期:2005-04-25 00:00:00

  • Altered expression of topoisomerase IIalpha contributes to cross-resistant to etoposide K562/MX2 cell line by aberrant methylation.

    abstract::KRN 8602 (MX2) is a novel morpholino anthracycline derivative having the chemical structure 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride. To investigate the mechanisms of resistance to MX2, we established an MX2-resistant phenotype (K562/MX2) of the human myelogeneous leukaemia cell line (K56...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6602498

    authors: Asano T,Nakamura K,Fujii H,Horichi N,Ohmori T,Hasegawa K,Isoe T,Adachi M,Otake N,Fukunaga Y

    更新日期:2005-04-25 00:00:00

  • Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1beta.

    abstract::Expression of vascular endothelial growth factor (VEGF), an important angiogenic factor in colon cancer, is tightly regulated by factors in the microenvironment. However, specific factors indigenous to the organ microenvironment of colon cancer growth that regulate VEGF expression in human colon cancer are not well de...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6690553

    authors: Akagi Y,Liu W,Xie K,Zebrowski B,Shaheen RM,Ellis LM

    更新日期:1999-07-01 00:00:00

  • E-cadherin relates to EGFR expression and lymph node metastasis in primary breast carcinoma.

    abstract::Expression of the calcium-dependent cell-cell adhesion molecule E-cadherin has been examined in 187 primary breast carcinomas using an immunohistochemical technique. The pattern and extent of reactivity has been correlated with clinicopathological data including tumour type, grade and lymph node status and with other ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.522

    authors: Jones JL,Royall JE,Walker RA

    更新日期:1996-10-01 00:00:00

  • ICI 182,780 (Fulvestrant)--the first oestrogen receptor down-regulator--current clinical data.

    abstract::ICI 182,780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antioestrogens--the oestrogen receptor (ER) down-regulators. Its unique mode of action and the absence of partial agonist activity make it a candidate for the treatment of advanced breast cancer in both pre- and postmenopausal women. Tam...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1054/bjoc.2001.1982

    authors: Robertson JF

    更新日期:2001-11-01 00:00:00

  • Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians.

    abstract:BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-019-0500-z

    authors: Nam GE,Cho KH,Han K,Kim CM,Han B,Cho SJ,Jung SJ,Kwon Y,Kim YH,Kim DH,Kim SM,Choi YS,Roh YK,Park YG

    更新日期:2019-07-01 00:00:00

  • Hospitalisation for venous thromboembolism in cancer patients and the general population: a population-based cohort study in Denmark, 1997-2006.

    abstract:BACKGROUND:Venous thromboembolism (VTE) frequently complicates cancer. Data on tumour-specific VTE predictors are limited, but may inform strategies to prevent thrombosis. METHODS:We computed incidence rates (IRs) with 95% confidence intervals (CIs) for VTE hospitalisation in a cohort of cancer patients (n=57,591) and...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605883

    authors: Cronin-Fenton DP,Søndergaard F,Pedersen LA,Fryzek JP,Cetin K,Acquavella J,Baron JA,Sørensen HT

    更新日期:2010-09-28 00:00:00