Abstract:
BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. RESULTS:During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current smoking, pack-years, and thyroid cancer. After adjustment for confounders, adjusted hazard ratios (95% confidence intervals) for thyroid cancer comparing current and former smokers to never smokers were 0.58 (0.45-0.75) and 0.93 (0.73-1.18), respectively. After further adjustment for BMI and TSH as potential mediators, this association was slightly attenuated, but remained significant. For women, current smokers tended to have a lower risk of thyroid cancer, but this association did not reach statistical significance. CONCLUSIONS:In this cohort study, current smoking was associated with a decreased risk of incident thyroid cancer in men but not in women and this association was observed even after adjusting for TSH and BMI levels as potential mediators. Further mechanistic studies are needed to elucidate the possible effect of smoking on the pathogenesis of thyroid cancer development.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Cho A,Chang Y,Ahn J,Shin H,Ryu Sdoi
10.1038/s41416-018-0224-5subject
Has Abstractpub_date
2018-08-01 00:00:00pages
638-645issue
5eissn
0007-0920issn
1532-1827pii
10.1038/s41416-018-0224-5journal_volume
119pub_type
杂志文章abstract::To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.304
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pub_type: 临床试验,杂志文章
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journal_title:British journal of cancer
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.269
更新日期:1982-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1054/bjoc.2001.2037
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.137
更新日期:1982-06-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1974.84
更新日期:1974-05-01 00:00:00
abstract::To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6601991
更新日期:2004-07-19 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.97
更新日期:1993-03-01 00:00:00
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6605438
更新日期:2009-12-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.588
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更新日期:2008-04-08 00:00:00
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doi:10.1038/bjc.1993.457
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更新日期:1973-09-01 00:00:00
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更新日期:2015-03-17 00:00:00
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更新日期:2005-04-25 00:00:00
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pub_type: 杂志文章
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更新日期:2005-04-25 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6690553
更新日期:1999-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.1996.522
更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1054/bjoc.2001.1982
更新日期:2001-11-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0500-z
更新日期:2019-07-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605883
更新日期:2010-09-28 00:00:00