Abstract:
BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. Here, we assess whether modified treatments for these patients have increased survival and identify new prognostic factors. METHODS:The United Kingdom GTD database was screened to identify all PSTT/ETT cases diagnosed between 1973 and 2014. Data and survival outcomes from our prior patient cohort (1976-2006) were compared to our new modern cohort (2007-2014), when intensified treatments were introduced. RESULTS:Of 54,743 GTD patients, 125 (0.23%) were diagnosed with PSTT and/or ETT. Probability of survival at 5 and 10 years following treatment was 80% (95% CI 72.8-87.6%) and 75% (95% CI 66.3-84.3%), respectively. Univariate analysis identified five prognostic factors for reduced overall survival (age, FIGO stage, time since antecedent pregnancy, hCG level, mitotic index) of which stage IV disease (HR 6.18, 95% CI 1.61-23.81, p = 0.008) and interval ≥48 months since antecedent pregnancy (HR 14.57, 95% CI 4.17-50.96, p < 0.001) were most significant on multivariable analysis. No significant differences in prognostic factors were seen between the old and new patient cohort. However, the new cohort received significantly more cisplatin-based and high-dose chemotherapy, and patients with an interval ≥48 months demonstrated an improved median overall survival (8.3 years, 95% CI 1.53-15.1, versus 2.6 years, 95% CI 0.73-4.44, p = 0.·005). CONCLUSION:PSTT/ETT with advanced FIGO stage or an interval ≥48 months from their last known pregnancy have poorer outcomes. Platinum-based and high-dose chemotherapy may help to improve survival in poor-prognosis patients.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJdoi
10.1038/s41416-019-0402-0subject
Has Abstractpub_date
2019-03-01 00:00:00pages
587-594issue
6eissn
0007-0920issn
1532-1827pii
10.1038/s41416-019-0402-0journal_volume
120pub_type
杂志文章abstract::The brain-specific angiogenesis inhibitor 1 gene has been isolated in an attempt to find fragments with p53 "functional" binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its par...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600067
更新日期:2002-02-01 00:00:00
abstract::Meningiomas are common, mostly benign, tumours arising from leptomeningeal cells of the meninges, which frequently contain mutations in the neurofibromatosis type 2 (NF2) gene. In this study, we analysed a protein product of the neurofibromatosis type 1 (NF1) gene, neurofibromin, in human established leptomeningeal ce...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.456
更新日期:1997-01-01 00:00:00
abstract::Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1/S arrest and leads to an inappropriate entry of cells with damaged DNA into the S phase, following treatment with ioni...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601307
更新日期:2003-10-20 00:00:00
abstract::Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2178
更新日期:2001-12-14 00:00:00
abstract::The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1983.271
更新日期:1983-12-01 00:00:00
abstract::We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.bjc.6603843
更新日期:2007-07-02 00:00:00
abstract::A previous publication (Leith et al., 1992) showed that administration of basic fibroblast growth factor (FGF-2, 0.25 mg kg-1, q.i.d. x 7) to mice bearing xenografted DLD-2 human colon cancers would increase treated tumour growth rates as compared to control neoplasms. Additionally, at the end of the 7 day treatment p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.418
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.526
更新日期:2013-01-15 00:00:00
abstract::In this study, the immunohistochemical expression of a new inducible elastase inhibitor, SKALP (skin-derived anti-leucoproteinase)/elafin, in the tissue of squamous cell carcinoma and uninvolved oesophageal mucosa was studied using a polyclonal rabbit anti-serum against SKALP/elafin. The results were compared with the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.511
更新日期:1997-01-01 00:00:00
abstract::Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of C...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690068
更新日期:1999-02-01 00:00:00
abstract::The aim of this study is to evaluate different options for introducing liquid-based cytology (LBC) and human papillomavirus (HPV) testing into the UK cervical cancer screening programme. These include options that incorporate HPV testing either as a triage for mild and borderline smear abnormalities or as a primary sc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601884
更新日期:2004-07-05 00:00:00
abstract::Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600148
更新日期:2002-02-12 00:00:00
abstract:BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.2012.284
更新日期:2012-07-24 00:00:00
abstract:BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0989-1
更新日期:2020-10-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1971.78
更新日期:1971-12-01 00:00:00
abstract:BACKGROUND:To enhance the success rate of nanocarrier-mediated chemotherapy combined with an anti-angiogenic agent, it is crucial to identify parameters for tumour vasculature that can predict a response to the treatment of the anti-angiogenic agent. METHODS:To apply transforming growth factor (TGF)-beta type I recept...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605367
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS:Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreemen...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.260
更新日期:2016-09-27 00:00:00
abstract::Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1956
更新日期:2001-09-01 00:00:00
abstract::Evidence in the literature suggests that hyperthermia (HT) or inhibitors of calmodulin can increase the sensitivity of rodent cells to bleomycin (BLM) by interfering with DNA repair functions. In an attempt to explore methods of improving the efficacy of thermochemotherapy we have investigated the individual and combi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.14
更新日期:1986-01-01 00:00:00
abstract::In a study of 157 patients with lymphoid malignancy, the phenotype of the tumour cells was correlated with the histological classification of the tumour using the Rappaport and the Kiel classifications. The markers used included E, Fc gamma, Fc micron (IgM) and C3d rosetting, estimation of SIg and CyIg, and tests for ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.137
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.9
更新日期:2014-03-04 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.269
更新日期:1994-07-01 00:00:00
abstract::Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.39
更新日期:1977-03-01 00:00:00
abstract::Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1970.59
更新日期:1970-09-01 00:00:00
abstract:BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.188
更新日期:2015-06-30 00:00:00
abstract:BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.457
更新日期:2014-10-14 00:00:00
abstract::Administration of 5-aminolaevulinic acid (ALA) leads to porphyrin accumulation in malignant and premalignant tissues, and ALA is used as a prodrug in photodynamic therapy (PDT). To understand the mechanism of porphyrin accumulation after the administration of ALA and to investigate whether ALA-induced protoporphyrin I...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.559
更新日期:1998-09-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.20
更新日期:2011-03-01 00:00:00
abstract::Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.45
更新日期:1976-03-01 00:00:00
abstract::Geographical correlations between standardized, mortality ratios (SMRs) of cancers and consumption of different types of alcoholic beverages (saké synthetic saké, shochu, beer, wine, and whisky), of cigarettes, and urbanization were examined for all 46 prefectures in Japan. Suggestive correlations were observed betwee...
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pub_type: 杂志文章
doi:10.1038/bjc.1979.200
更新日期:1979-09-01 00:00:00