Intrathecal chemotherapy. Selection of cytostatic agents.

abstract：:Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...

journal_title：British journal of cancer

authors： Rao KV,Pai SR,Bapat CV

更新日期：1974-08-01 00:00:00

abstract：:The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and ...

journal_title：British journal of cancer

authors： Rubens RD,Vaughan-Smith S,Dulbecco R

更新日期：1975-09-01 00:00:00

abstract：:There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....

journal_title：British journal of cancer

authors： Campbell NC,Elliott AM,Sharp L,Ritchie LD,Cassidy J,Little J

更新日期：2001-04-06 00:00:00

abstract：:SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is an anti-tumour agent that has a highly selective toxicity to hypoxic cells. In this study we delineate the role of several different bioreductive enzymes in the metabolism of SR 4233 by two tumour cell lines HT 1080 (human fibrosarcoma) and SCCVII (mouse carcinoma)....

journal_title：British journal of cancer

authors： Wang J,Biedermann KA,Wolf CR,Brown JM

更新日期：1993-02-01 00:00:00

abstract：:Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the ge...

journal_title：British journal of cancer

authors： Soeripto,Jensen OM,Muir CS

更新日期：1977-07-01 00:00:00

abstract：:Lines of fibroblasts have been established from normal individuals and from patients diagnosed as suffering from one of the mucopolysaccharidoses or mucopolysaccharide-storage diseases. Transformation of these lines with SV40 virus has been found to reduce their capacity to secrete sulphated mucopolysaccharides into t...

journal_title：British journal of cancer

authors： Webb T

更新日期：1977-07-01 00:00:00

abstract：:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new ...

journal_title：British journal of cancer

authors： Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis S

更新日期：2009-05-05 00:00:00

abstract：:This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearrange...

journal_title：British journal of cancer

authors： Butler M,Corbally N,Dervan PA,Carney DN

更新日期：1997-01-01 00:00:00

abstract：:Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic signifi...

journal_title：British journal of cancer

authors： Cheng HL,Liu HS,Lin YJ,Chen HH,Hsu PY,Chang TY,Ho CL,Tzai TS,Chow NH

更新日期：2005-05-23 00:00:00

abstract：:The association between body height and the incidence rate of breast cancer has been examined in 236 cases of breast cancer that occurred among 23,831 Norwegian women during 11-14 years of follow-up. At the time of height measurement they were 35-51 years of age. The age-adjusted incidence rate ratio (IRR) of breast c...

journal_title：British journal of cancer

authors： Vatten LJ,Kvinnsland S

更新日期：1990-06-01 00:00:00

abstract：:In advanced pancreatic cancer, level one evidence has established a significant survival advantage with chemotherapy, compared to best supportive care. The treatment-associated toxicity needs to be evaluated. This study examines the secondary outcome measures for chemotherapy in advanced pancreatic cancer using meta-a...

journal_title：British journal of cancer

authors： Sultana A,Tudur Smith C,Cunningham D,Starling N,Neoptolemos JP,Ghaneh P

更新日期：2008-07-08 00:00:00

abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

journal_title：British journal of cancer

authors： Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

更新日期：2010-01-19 00:00:00

abstract：:Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...

journal_title：British journal of cancer

authors： Wang ZJ,Churchman M,Campbell IG,Xu WH,Yan ZY,McCluggage WG,Foulkes WD,Tomlinson IP

更新日期：1999-04-01 00:00:00

abstract：:Detailed data and statistics per each morphological site of various digestive neoplasms were obtained for the period 1976-87 from the Vaud Cancer Registry datafile, a population-based cancer registration scheme covering about 530,000 inhabitants from the French-speaking part of Switzerland. Tabulations presented inclu...

journal_title：British journal of cancer

authors： Levi F,La Vecchia C,Franceschi S,Te VC

更新日期：1991-04-01 00:00:00

abstract：:All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findi...

journal_title：British journal of cancer

authors： Morrow RH,Pike MC,Smith PG

更新日期：1977-05-01 00:00:00

abstract：:Overexpression of the MDR1 product, P-glycoprotein (Pgp), has been shown to be one of the mechanisms underlying the development of multidrug resistance (MDR). Recently, one mutant p53 has been shown to stimulate the MDR1 gene promoter in vitro, whereas wild-type p53 repressed this activity. We measured Pgp and p53 exp...

journal_title：British journal of cancer

authors： De Angelis P,Stokke T,Smedshammer L,Lothe RA,Lehne G,Chen Y,Clausen OP

更新日期：1995-08-01 00:00:00

abstract：:We have studied the ability of cyclosporin A (CsA) and a non-immunosuppressive analogue, O-acetyl cyclosporin A (OACsA, B3-243) to inhibit the growth of human lung cancer cells in vitro. Using continuous drug exposure and the MTT colorimetric assay to determine cell growth we found that CsA produced partial growth inh...

journal_title：British journal of cancer

authors： Twentyman PR,Wright KA,Wallace HM

更新日期：1992-03-01 00:00:00

abstract：:Human dialysable Transfer Factor (TFd) extracted from lymphocytes of patients with transitional cell carcinoma of bladder (TCCB) was replicated in culture by lymphoblastoid cell lines. The effectiveness of two such TFdLs produced in vitro in transferring sensitivity to TCCB was assessed in the lymphocyte migration tes...

journal_title：British journal of cancer

authors： Pizza G,Viza D,Boucheix C,Corrado F

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：BACKGROUND:Based on the microRNA (miRNA) signature of bladder cancer (BC) by deep sequencing, we recently found that several double-stranded mature miRNAs derived from the same pre-miRNAs were sufficiently expressed and acted as tumour suppressors by regulating common target genes in BC. Our deep-sequencing signature o...

journal_title：British journal of cancer

authors： Sakaguchi T,Yoshino H,Yonemori M,Miyamoto K,Sugita S,Matsushita R,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2017-04-11 00:00:00

abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

journal_title：British journal of cancer

authors： Kronqvist P,Kuopio T,Collan Y

更新日期：2000-05-01 00:00:00

abstract：:The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...

journal_title：British journal of cancer

authors： Otu AA,Russell RJ,Wilkinson PC,White RG

更新日期：1977-09-01 00:00:00

abstract：:In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patie...

journal_title：British journal of cancer

authors： Planting AS,van der Burg ME,van den Bent MJ,de Boer-Dennert M,Stoter G,Verweij J

更新日期：1996-05-01 00:00:00

abstract：:In this study we investigated the tumorigenicity, growth pattern and spontaneous metastatic ability of a series of nine human colorectal carcinoma cell lines after subcutaneous and intracaecal xenografting in nude mice. CaCo2 cells were found to be poorly tumorigenic to non-tumorigenic in either site; the other cell l...

journal_title：British journal of cancer

authors： de Vries JE,Dinjens WN,De Bruyne GK,Verspaget HW,van der Linden EP,de Bruïne AP,Mareel MM,Bosman FT,ten Kate J

更新日期：1995-02-01 00:00:00

abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...

journal_title：British journal of cancer

authors： Hosokawa S,Tagawa T,Niki H,Hirakawa Y,Nohga K,Nagaike K

更新日期：2003-10-20 00:00:00

abstract：:Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major influence affecting outcome. Children with tumours confined to the tissue of origin with no evidence of nodal or metastati...

journal_title：British journal of cancer

authors： Kingston JE,McElwain TJ,Malpas JS

更新日期：1983-08-01 00:00:00

abstract：:Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...

journal_title：British journal of cancer

authors： Steven FS,Hill RJ

更新日期：1988-11-01 00:00:00

abstract：:HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly characterized. Here, we report the generation and characterization of CD4+ T cell clones specifically recognizing a HER-2/neu-derived peptide (776-788) [designa...

journal_title：British journal of cancer

authors： Sotiriadou R,Perez SA,Gritzapis AD,Sotiropoulou PA,Echner H,Heinzel S,Mamalaki A,Pawelec G,Voelter W,Baxevanis CN,Papamichail M

更新日期：2001-11-16 00:00:00

abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...

journal_title：British journal of cancer

authors： Yang TJ,Chandler JP,Dunne-Anway S

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Temsirolimus was approved in Europe as first-line treatment of poor-prognosis advanced renal cell carcinoma (advRCC) based on significant clinical benefits. METHODS:Patients with advRCC and multiple poor-prognostic factors were randomly assigned to receive 25 mg intravenous temsirolimus weekly, interferon-a...

journal_title：British journal of cancer

authors： Yang S,de Souza P,Alemao E,Purvis J

更新日期：2010-05-11 00:00:00