当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence.

Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence.

Abstract：

BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver metastases. In this study the prognostic value of KCNQ1 in stage II and stage III colon cancer patients was examined. METHODS:KCNQ1 mRNA expression was assessed in 90 stage II colon cancer patients (AMC-AJCCII-90) using microarray gene expression data. Subsequently, KCNQ1 protein expression was evaluated in an independent cohort of 386 stage II and stage III colon cancer patients by immunohistochemistry of tissue microarrays. RESULTS:Low KCNQ1 mRNA expression in stage II microsatellite stable (MSS) colon cancers was associated with poor disease-free survival (DFS) (P=0.025). Loss of KCNQ1 protein expression from epithelial cells was strongly associated with poor DFS in stage II MSS (P<0.0001), stage III MSS (P=0.0001) and stage III microsatellite instable colon cancers (P=0.041). KCNQ1 seemed an independent prognostic value in addition to other high-risk parameters like angio-invasion, nodal stage and microsatellite instability-status. CONCLUSIONS:We conclude that KCNQ1 is a promising biomarker for prediction of disease recurrence and may aid stratification of patients with stage II MSS colon cancer for adjuvant chemotherapy.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

doi

10.1038/bjc.2016.376

subject

Has Abstract

pub_date

2016-12-06 00:00:00

pages

1565-1574

issue

12

eissn

0007-0920

issn

1532-1827

pii

bjc2016376

journal_volume

115

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • The impact of psychiatric utilisation prior to cancer diagnosis on survival of solid organ malignancies.

    abstract：BACKGROUND:Among patients with cancer, prior research suggests that patients with mental illness may have reduced survival. The objective was to assess the impact of psychiatric utilisation (PU) prior to cancer diagnosis on survival outcomes. METHODS:All residents of Ontario diagnosed with one of the top 10 malignanci...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0390-0

    authors： Klaassen Z,Wallis CJD,Goldberg H,Chandrasekar T,Sayyid RK,Williams SB,Moses KA,Terris MK,Nam RK,Urbach D,Austin PC,Kurdyak P,Kulkarni GS

    更新日期：2019-04-01 00:00:00

  • Rat lymphocyte mitogenesis by aggregation factor from rat ascites hepatoma cell surface.

    abstract：:Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1978.192

    authors： Kuratsu J,Yoshinaga M,Hayashi H

    更新日期：1978-08-01 00:00:00

  • Sexual behaviour and smoking as determinants of cervical HPV infection and of CIN3 among those infected: a case-control study nested within the Manchester cohort.

    abstract：:To distinguish risk factors for acquisition of cervical human papillomavirus (HPV) infection from the determinants of neoplasia among infected individuals we have conducted a three-arm case-control study nested within a large population-based cohort of women (the Manchester cohort) screened for HPV at entry using L1 c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1523

    authors： Deacon JM,Evans CD,Yule R,Desai M,Binns W,Taylor C,Peto J

    更新日期：2000-12-01 00:00:00

  • Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression.

    abstract：:Tumour-associated angiogenesis is partly regulated by the hypoxia-inducible factor (HIF) pathway. Endocrine tumours are highly vascularised and the molecular mechanisms of their angiogenesis are not fully delineated. The aim of this study is to evaluate angiogenesis and expression of HIF-related molecules in a series ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602245

    authors： Couvelard A,O'Toole D,Turley H,Leek R,Sauvanet A,Degott C,Ruszniewski P,Belghiti J,Harris AL,Gatter K,Pezzella F

    更新日期：2005-01-17 00:00:00

  • Clinical utility of the IHC4+C score in oestrogen receptor-positive early breast cancer: a prospective decision impact study.

    abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.222

    authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

    更新日期：2015-07-28 00:00:00

  • A population-based survival study on female breast cancer in Madras, India.

    abstract：:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.137

    authors： Gajalakshmi CK,Shanta V,Swaminathan R,Sankaranarayanan R,Black RJ

    更新日期：1997-01-01 00:00:00

  • Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin.

    abstract：BACKGROUND:Selecting patients with 'sufficient life expectancy' for Phase I oncology trials remains challenging. The Royal Marsden Hospital Score (RMS) previously identified high-risk patients as those with ≥ 2 of the following: albumin <35 g l(-1); LDH > upper limit of normal; >2 metastatic sites. This study developed...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.371

    authors： Ploquin A,Olmos D,Lacombe D,A'Hern R,Duhamel A,Twelves C,Marsoni S,Morales-Barrera R,Soria JC,Verweij J,Voest EE,Schöffski P,Schellens JH,Kramar A,Kristeleit RS,Arkenau HT,Kaye SB,Penel N

    更新日期：2012-09-25 00:00:00

  • High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.

    abstract：BACKGROUND:Gestational trophoblastic diseases (GTDs) are related to trophoblasts, and human chorionic gonadotropin (hCG) is secreted by GTDs as well as normal placentas. However, the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregna...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.496

    authors： Niimi K,Yamamoto E,Fujiwara S,Shinjo K,Kotani T,Umezu T,Kajiyama H,Shibata K,Ino K,Kikkawa F

    更新日期：2012-12-04 00:00:00

  • The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death.

    abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-018-0232-5

    authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

    更新日期：2018-11-01 00:00:00

  • Enhancing treatment decision-making: pilot study of a treatment decision aid in stage IV non-small cell lung cancer.

    abstract：:We developed a decision aid (DA) for patients with metastatic non-small cell lung cancer (NSCLC), to better inform patients of their prognosis and treatment options, and facilitate involvement in decision-making. In a pilot study, 20 patients with metastatic NSCLC attending outpatient clinics at a major cancer centre,...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604395

    authors： Leighl NB,Shepherd FA,Zawisza D,Burkes RL,Feld R,Waldron J,Sun A,Payne D,Bezjak A,Tattersall MH

    更新日期：2008-06-03 00:00:00

  • Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

    abstract：:Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600877

    authors： Broutet N,Plebani M,Sakarovitch C,Sipponen P,Mégraud F,Eurohepygast Study Group.

    更新日期：2003-04-22 00:00:00

  • Circulating immune complexes and autoantibodies in lung cancer.

    abstract：:The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.45

    authors： Guy K,Di Mario U,Irvine WJ,Hunter AM,Hadley A,Horne NW

    更新日期：1981-03-01 00:00:00

  • Mechanisms of adverse effects of anti-VEGF therapy for cancer.

    abstract：:Advances in understanding the role of vascular endothelial growth factor (VEGF) in normal physiology are giving insight into the basis of adverse effects attributed to the use of VEGF inhibitors in clinical oncology. These effects are typically downstream consequences of suppression of cellular signalling pathways imp...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6603813

    authors： Kamba T,McDonald DM

    更新日期：2007-06-18 00:00:00

  • Adding free to total prostate-specific antigen levels in trials of prostate cancer screening.

    abstract：:We used a nested case-control design on data from men in four prospective studies (from the UK, Maryland in the USA, and two from Finland) with available stored serum samples to determine whether there was an advantage in measuring both free prostate-specific antigen (PSA) and total PSA as a potential screening test f...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0988

    authors： Wald NJ,Watt HC,George L,Knekt P,Helzlsouer KJ,Tuomilehto J

    更新日期：2000-02-01 00:00:00

  • Overestimation of carboplatin doses is avoided by radionuclide GFR measurement.

    abstract：BACKGROUND:Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose. Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR (rGFR)), however, estimation equations are available (estimated GFR (eGFR)). Our aim was to assess the accuracy of three eGFR equations and the...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.393

    authors： Craig AJ,Samol J,Heenan SD,Irwin AG,Britten A

    更新日期：2012-10-09 00:00:00

  • A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence.

    abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0764-3

    authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

    更新日期：2020-04-01 00:00:00

  • Molecular alterations associated with liver metastases development in colorectal cancer patients.

    abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.184

    authors： Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJ

    更新日期：2011-07-12 00:00:00

  • Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumour-derived vascular endothelial growth factor in vivo and in vitro.

    abstract：:Vascular endothelial growth factor is an important angiogenic factor for tumour progression because it increases endothelial-cell proliferation and remodels extracellular matrix in blood vessels. We demonstrated that hyperthermia at 42 degrees C, termed heat shock, suppressed the gene expression and production of vasc...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600268

    authors： Sawaji Y,Sato T,Takeuchi A,Hirata M,Ito A

    更新日期：2002-05-20 00:00:00

  • Predicted trends in long-term breast cancer survival in England and Wales.

    abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603668

    authors： Woods LM,Rachet B,Cooper N,Coleman MP

    更新日期：2007-04-10 00:00:00

  • PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions.

    abstract：:Ovarian cancer is the fifth leading cause of female cancer deaths in the Western world. Significant progress has been made in the treatment of patients with ovarian cancer, however, the majority of patients experience disease recurrence and new therapies are being sought for such patients. Clinical investigation of po...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2015.395

    authors： Ledermann JA,El-Khouly F

    更新日期：2015-12-15 00:00:00

  • Oestrogen-receptor status and sites of metastasis in breast cancer.

    abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.205

    authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

    更新日期：1981-09-01 00:00:00

  • Quantitative evaluation of metastases in axillary lymph nodes of breast cancer.

    abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601248

    authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

    更新日期：2003-11-03 00:00:00

  • Phase II study of lonidamine in metastatic breast cancer.

    abstract：:Thirty patients with previously treated metastatic breast cancer were entered in a phase II study with oral lonidamine. Twenty-eight patients are evaluable for toxicity and 25 for response. A partial remission was obtained in four patients (16%) and disease stability in 11 (44%): 10 patients progressed (40%). Toxicity...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1989.51

    authors： Pronzato P,Amoroso D,Bertelli G,Conte PF,Cusimano MP,Ciottoli GB,Gulisano M,Lionetto R,Rosso R

    更新日期：1989-02-01 00:00:00

  • Erythrocyte sedimentation rate and anaemia are independent predictors of survival in patients with clear cell renal cell carcinoma.

    abstract：BACKGROUND:The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by small sample sizes. METHODS:The Cox proportional hazards model was used...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.565

    authors： Choi Y,Park B,Kim K,Jeong BC,Seo SI,Jeon SS,Choi HY,Lee JE,Lee HM

    更新日期：2013-02-05 00:00:00

  • Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study.

    abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0523-5

    authors： Kim JW,Lee KH,Kim JW,Suh KJ,Nam AR,Bang JH,Bang YJ,Oh DY

    更新日期：2019-08-01 00:00:00

  • A preliminary study of intravenous methanol extraction residue of BCG in treatment of advanced cancer.

    abstract：:Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1977.198

    authors： Robinson E,Bartal A,Honigman J,Cohen Y

    更新日期：1977-09-01 00:00:00

  • Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer.

    abstract：BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.416

    authors： Greystoke A,Dean E,Saunders MP,Cummings J,Hughes A,Ranson M,Dive C,Renehan AG

    更新日期：2012-10-23 00:00:00

  • A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix.

    abstract：:We investigated the feasibility and the anti-tumour activity of weekly cisplatin and the simultaneous application of local hyperthermia in patients with a pelvic recurrence of cervical cancer in previously irradiated area. Dose levels of cisplatin 60 mg m(-2), 70 mg m(-2) and 80 mg m(-2) were studied. Treatment object...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6690533

    authors： de Wit R,van der Zee J,van der Burg ME,Kruit WH,Logmans A,van Rhoon GC,Verweij J

    更新日期：1999-07-01 00:00:00

  • Changing patterns of relapse in Hodgkin's disease.

    abstract：:The patterns of early and late relapses (those occurring later than 3 years after diagnosis) in 432 patients achieving complete remission after treatment for stage I and II Hodgkin's disease at the Royal Marsden Hospital between 1964 and 1983 were studied to identify factors predicting for late relapse. The incidence ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1989.257

    authors： Duchesne G,Crow J,Ashley S,Brada M,Horwich A

    更新日期：1989-08-01 00:00:00

  • Activation and activities of the p53 tumour suppressor protein.

    abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1054/bjoc.2001.2128

    authors： Bálint E E,Vousden KH

    更新日期：2001-12-14 00:00:00