Changing patterns of relapse in Hodgkin's disease.


:The patterns of early and late relapses (those occurring later than 3 years after diagnosis) in 432 patients achieving complete remission after treatment for stage I and II Hodgkin's disease at the Royal Marsden Hospital between 1964 and 1983 were studied to identify factors predicting for late relapse. The incidence of early relapse has fallen progressively in recent treatment eras as staging procedures and management have improved but in contrast there has been no decrease in the risk of late relapse. The incidence of late relapse was greater in patients treated with radiotherapy rather than combined modality therapy (P less than 0.05). However, patients who were clinically staged and treated with combined modality therapy retained as high a risk of relapse between 3 and 6 years as in years 2 and 3. The risk of late relapse was also greater in patients with stage II disease and in those without B symptoms at presentation. Patients falling into the higher risk categories for late relapse require continued close follow-up beyond 3 years to monitor for possible relapse.


Br J Cancer


Duchesne G,Crow J,Ashley S,Brada M,Horwich A




Has Abstract


1989-08-01 00:00:00












  • The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaptopurine-sensitive and -resistant cell culture lines.

    abstract::6-Mercaptopurine (MP)-sensitive and -resistant cell culture lines were used to further characterize the apparent ability of MP nucleotide derivatives to overcome resistance to the parent drug. 6-Mercaptopurine-9-beta-D-ribofuranoside 5'-monophosphate [MPRP], bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5', 5"'-monoph...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Johnston HP,Hawley P,White SE,Gibson I,Tidd DM

    更新日期:1985-04-01 00:00:00

  • Cell-cell contact affects cellular sensitivity to hyperthermia.

    abstract::The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Dobrucki J,Bleehen NM

    更新日期:1985-12-01 00:00:00

  • Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope.

    abstract::HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly characterized. Here, we report the generation and characterization of CD4+ T cell clones specifically recognizing a HER-2/neu-derived peptide (776-788) [designa...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sotiriadou R,Perez SA,Gritzapis AD,Sotiropoulou PA,Echner H,Heinzel S,Mamalaki A,Pawelec G,Voelter W,Baxevanis CN,Papamichail M

    更新日期:2001-11-16 00:00:00

  • Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.

    abstract::The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Maddy SQ,Chisholm GD,Busuttil A,Habib FK

    更新日期:1989-07-01 00:00:00

  • External validation of serum hCG cutoff levels for prediction of resistance to single-agent chemotherapy in patients with persistent trophoblastic disease.

    abstract::Van Trommel et al have previously shown that serum human chorionic gonadotropin (hCG) cutoff levels can provide early prediction of resistance to first-line methotrexate (MTX) in patients with persistent trophoblastic disease (PTD). In this study, we validate this approach of prediction of resistance to single-agent c...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kerkmeijer LG,Thomas CM,Harvey R,Sweep FC,Mitchell H,Massuger LF,Seckl MJ

    更新日期:2009-03-24 00:00:00

  • Studies with bleomycin and misonidazole on aerated and hypoxic cells.

    abstract::Bleomycin is a chemotherapuetic drug used primarily in the treatment of squamous-cell carcinoma, while misonidazole is an effective radiosensitizer and potent cytotoxic agent selectively affecting hypoxic cells. V79 Chinese hamster cells were used to investigate the cytotoxicity of bleomycin (BLM) under aerated and hy...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Roizin-Towle L,Hall EJ

    更新日期:1978-02-01 00:00:00

  • Characterization of human sarcoma antigen S3.

    abstract::An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sethi JK,Hirshaut Y

    更新日期:1981-03-01 00:00:00

  • Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition.

    abstract::The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGF...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L

    更新日期:2007-09-17 00:00:00

  • Breast cancer incidence in food- vs non-food-producing areas in Norway: possible beneficial effects of World War II.

    abstract::It has been suggested that World War II influenced breast cancer risk among Norwegian women by affecting adolescent growth. Diet changed substantially during the war, and the reduction in energy intake was assumed to be larger in non-food-producing than in food-producing municipalities. In the present study, we have l...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Robsahm TE,Tretli S

    更新日期:2002-02-01 00:00:00

  • Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer.

    abstract::HMGI-C belongs to the high-mobility-group-protein (HMG) family of architectural transcription factors and considerable interest has recently been shown in its expression in neoplastic tissues and apparent involvement in tumorigenesis. We could previously demonstrate an expression of HMGI-C mRNA in the peripheral blood...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Langelotz C,Schmid P,Jakob C,Heider U,Wernecke KD,Possinger K,Sezer O

    更新日期:2003-05-06 00:00:00

  • DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer.

    abstract:BACKGROUND:Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. METHODS:Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine the DKC1 expressio...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hou P,Shi P,Jiang T,Yin H,Chu S,Shi M,Bai J,Song J

    更新日期:2020-03-01 00:00:00

  • The prognostic significance of DNA flow cytometry in breast cancer: results from 881 patients treated in a single centre.

    abstract::In this single-centre study of 881 patients, S-phase fraction (SPF) was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SAR). Further, SPF had independent prognostic significance when considering a range of other clinicopathological...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Camplejohn RS,Ash CM,Gillett CE,Raikundalia B,Barnes DM,Gregory WM,Richards MA,Millis RR

    更新日期:1995-01-01 00:00:00

  • Cytogenetic study in therapy-related myelodysplastic syndromes (t-MDS) and acute non-lymphocytic leukaemia (t-ANLL).

    abstract::A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

    更新日期:1990-03-01 00:00:00

  • Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer.

    abstract:BACKGROUND:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epidemiology studies, such as studies of disease prognosis. However, TMA data are particularly prone to missingness. A variety of methods to deal with missing data are available. However, the v...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Ali AM,Dawson SJ,Blows FM,Provenzano E,Ellis IO,Baglietto L,Huntsman D,Caldas C,Pharoah PD

    更新日期:2011-02-15 00:00:00

  • The utility and cost of routine follow-up procedures in the surveillance of ovarian and primary peritoneal carcinoma: a 16-year institutional review.

    abstract:BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rettenmaier NB,Rettenmaier CR,Wojciechowski T,Abaid LN,Brown JV 3rd,Micha JP,Goldstein BH

    更新日期:2010-11-23 00:00:00

  • Q-TWiST analysis of lapatinib combined with capecitabine for the treatment of metastatic breast cancer.

    abstract::The addition of lapatinib (Tykerb/Tyverb) to capecitabine (Xeloda) delays disease progression more effectively than capecitabine monotherapy in women with previously treated HER2+ metastatic breast cancer (MBC). The quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TWiST) method was used to...

    journal_title:British journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Sherrill B,Amonkar MM,Stein S,Walker M,Geyer C,Cameron D

    更新日期:2008-09-02 00:00:00

  • Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.

    abstract:BACKGROUND:Human polypyrimidine tract binding protein 3 (PTBP3) was first discovered in 1999 and has been well characterised as a differentiation regulator. However, its role in human cancer has rarely been reported. Our previous study revealed increased PTBP3 protein level in gastric cancer tissues. Downregulation of ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

    更新日期:2017-03-28 00:00:00

  • Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes.

    abstract::Human topoisomerase II enzymes are targets for a number of widely used anticancer agents. We have analysed a lung adenocarcinoma cell line CALU3, which has co-amplified topoisomerase II alpha and ERBB2 sequences, for the structure of the amplicon and for expression of both topoisomerase II alpha and beta. The region o...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Coutts J,Plumb JA,Brown R,Keith WN

    更新日期:1993-10-01 00:00:00

  • A phase II study of capecitabine and docetaxel combination chemotherapy in patients with advanced gastric cancer.

    abstract::Capecitabine and docetaxel have considerable single-agent activity in gastric cancer with distinct mechanisms of action and no overlap of key toxicities. A synergistic interaction between these two drugs is mediated by taxane-induced upregulation of thymidine phosphorylase. We investigated the activity and the feasibi...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Park YH,Ryoo BY,Choi SJ,Kim HT

    更新日期:2004-04-05 00:00:00

  • Single-visit approach of cervical cancer screening: see and treat in Indonesia.

    abstract:BACKGROUND:We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS:Women having limited access to health-care facilities were screen...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Vet JN,Kooijman JL,Henderson FC,Aziz FM,Purwoto G,Susanto H,Surya IG,Budiningsih S,Cornain S,Fleuren GJ,Trimbos JB,Peters AA

    更新日期:2012-08-21 00:00:00

  • Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status.

    abstract::Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Masson P,Pålsson B,Andrén-Sandberg A

    更新日期:1990-07-01 00:00:00

  • miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells.

    abstract:BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yang Z,Wang XL,Bai R,Liu WY,Li X,Liu M,Tang H

    更新日期:2016-09-06 00:00:00

  • Context-dependent effects of cellular senescence in cancer development.

    abstract::Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

    更新日期:2016-05-24 00:00:00

  • Cross-reactivity between Candida albicans and human ovarian carcinoma as revealed by monoclonal antibodies PA10F and C6.

    abstract::Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and im...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Schneider J,Moragues D,Martínez N,Romero H,Jimenez E,Pontón J

    更新日期:1998-03-01 00:00:00

  • Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer.

    abstract::Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ostrowski J,Trzeciak L,Kołodziejski J,Bomsztyk K

    更新日期:1998-11-01 00:00:00

  • Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations.

    abstract::High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Boland I,Vassal G,Morizet J,Terrier-Lacombe MJ,Valteau-Couanet D,Kalifa C,Hartmann O,Gouyette A

    更新日期:1999-02-01 00:00:00

  • 5'-Nucleotidase activity and arachidonate metabolism in doxorubicin sensitive and resistant P388 cells.

    abstract::5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ramu A,Glaubiger D,Soprey P,Reaman GH,Feuerstein N

    更新日期:1984-04-01 00:00:00

  • Similarities of the anti-tumour actions of endotoxin, lipid A and double-stranded RNA.

    abstract::Double stranded RNA (dsRNA) whether isolated from a fungal virus or prepared synthetically (i.e., Poly I Poly C) and endotoxin were found to exert very similar effects on syngeneic murine lymphomata and fibrosarcomata. They cause complete regressions of some established subcutaneous (s.c.) or intradermal (i.d.) tumour...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Parr I,Wheeler E,Alexander P

    更新日期:1973-05-01 00:00:00

  • Acquisition of platinum drug resistance and platinum cross resistance patterns in a panel of human ovarian carcinoma xenografts.

    abstract::In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Jones M,Siracky J,Kelland LR,Harrap KR

    更新日期:1993-01-01 00:00:00

  • Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.

    abstract::To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No germline mutations we...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Zelada-Hedman M,Børresen-Dale AL,Claro A,Chen J,Skoog L,Lindblom A

    更新日期:1997-01-01 00:00:00