Abstract：
:The patterns of early and late relapses (those occurring later than 3 years after diagnosis) in 432 patients achieving complete remission after treatment for stage I and II Hodgkin's disease at the Royal Marsden Hospital between 1964 and 1983 were studied to identify factors predicting for late relapse. The incidence of early relapse has fallen progressively in recent treatment eras as staging procedures and management have improved but in contrast there has been no decrease in the risk of late relapse. The incidence of late relapse was greater in patients treated with radiotherapy rather than combined modality therapy (P less than 0.05). However, patients who were clinically staged and treated with combined modality therapy retained as high a risk of relapse between 3 and 6 years as in years 2 and 3. The risk of late relapse was also greater in patients with stage II disease and in those without B symptoms at presentation. Patients falling into the higher risk categories for late relapse require continued close follow-up beyond 3 years to monitor for possible relapse.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Duchesne G,Crow J,Ashley S,Brada M,Horwich Adoi
10.1038/bjc.1989.257subject
Has Abstractpub_date
1989-08-01 00:00:00pages
227-30issue
2eissn
0007-0920issn
1532-1827journal_volume
60pub_type
杂志文章abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600780
更新日期：2003-02-24 00:00:00
abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.617
更新日期：1998-10-01 00:00:00
abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1824
更新日期：2001-06-01 00:00:00
abstract：:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602468
更新日期：2005-03-28 00:00:00
abstract：:DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presenc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.268
更新日期：1988-11-01 00:00:00
abstract：:Actin has been measured in subcellular fractions from Rat-1 fibroblasts and in Rous sarcoma virus-transformed Rat-1 cells (VIT), using the DNase 1 inhibition assay. The transformed cells showed a significant shift in the actin monomer (G)in equilibrium with polymer (F) equilibrium within the cell cytosol, and a signif...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.74
更新日期：1986-04-01 00:00:00
abstract：:HER-2/neu is a tumour antigen that is overexpressed in human breast tumours. Among the vaccine strategies developed to overcome immune tolerance to self-proteins, vaccination with anti-idiotypic (anti-Id) antibodies has been described as a promising approach for treatment of several malignant diseases. To develop an a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601825
更新日期：2004-05-17 00:00:00
abstract：BACKGROUND:Tumour budding has been reported to reflect invasiveness, metastasis and unfavourable prognosis in colorectal cancer. The aim of the study was to examine the relationship between tumour budding and clinicopathological characteristics, tumour microenvironment and survival in patients with primary operable col...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.173
更新日期：2016-07-12 00:00:00
abstract：:Oral capecitabine is a highly active, well-tolerated and convenient treatment for breast and colorectal cancer. This trial assessed the efficacy and safety of single-agent capecitabine in patients with previously treated ovarian cancer. A total of 29 patients with platinum-pretreated relapsed ovarian cancer were enrol...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601381
更新日期：2003-11-17 00:00:00
abstract：:Human topoisomerase II enzymes are targets for a number of widely used anticancer agents. We have analysed a lung adenocarcinoma cell line CALU3, which has co-amplified topoisomerase II alpha and ERBB2 sequences, for the structure of the amplicon and for expression of both topoisomerase II alpha and beta. The region o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.430
更新日期：1993-10-01 00:00:00
abstract：:Deregulated expression of myc proto-oncogenes is implicated in several human neoplasias. We analysed the expression of c-myc, N-myc, L-myc, max and RB1 mRNAs in a panel of human gliomas and glioma cell lines and compared the findings with normal neural cells. The max and RB1 genes were included in the study because th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.3
更新日期：1994-01-01 00:00:00
abstract：:Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cance...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602314
更新日期：2005-01-17 00:00:00
abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6603494
更新日期：2007-02-12 00:00:00
abstract：BACKGROUND:Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate pharmacodynamic biomarker...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.456
更新日期：2011-12-06 00:00:00
abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.310
更新日期：1990-09-01 00:00:00
abstract：:One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intra...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.87
更新日期：1989-03-01 00:00:00
abstract：:Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602422
更新日期：2005-03-28 00:00:00
abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0232-5
更新日期：2018-11-01 00:00:00
abstract：:Mediastinal masses include a wide variety of tumours and remain an interesting diagnostic challenge for radiologist. We performed positron emission tomography (PET) studies of primary mediastinal tumours in order to predict the malignancy of these tumours preoperatively. Twenty-two patients with primary mediastinal tu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.157
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01152-5
更新日期：2020-11-17 00:00:00
abstract：:The syndecans, a family of cell-surface heparan sulphate proteoglycans, have been proposed to mediate cellular interactions with extracellular effector molecules, such as growth factors and components of the extracellular matrix, during critical phases of development. Transcripts of all four syndecans are expressed at...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.147
更新日期：1998-03-01 00:00:00
abstract：:Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.373
更新日期：1998-06-01 00:00:00
abstract：:Tamoxifen is currently established as the endocrine treatment of choice in breast cancer. In advanced breast cancer, response rates of up to 60% in women with oestrogen receptor (ER)-positive tumours have been reported. In early breast cancer, tamoxifen can produce significant benefits, both statistically and clinical...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.753
更新日期：1998-09-01 00:00:00
abstract：:There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance to cytotoxic therapy. The impact of inflammation on drug disposition was studied in mice bearing a number of common tumour xenografts. C57BL/6 mice were inoculat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604101
更新日期：2008-01-15 00:00:00
abstract：:We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture, TIL showed undetect...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600679
更新日期：2003-01-27 00:00:00
abstract：:The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.172
更新日期：1978-07-01 00:00:00
abstract：:Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-conserving surgery supplemented with radiotherapy. However, most D...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-019-0478-6
更新日期：2019-08-01 00:00:00
abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.512
更新日期：1993-12-01 00:00:00
abstract：:Transformation of primary hamster embryo cells was investigated using 3-methylcholanthrene (MCA), a combination of MCA and 12-O-tetradecanoylphorbol-13-acetate (TPA), and initiation with MCA or dibenz(a,h)anthracene (DBA) followed by promotion with TPA. Evidence for transformation was (a) abnormal cellular morphology,...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.2
更新日期：1979-01-01 00:00:00
abstract：:In a prospective cohort study in Denmark of 8736 randomly selected people, no evidence was found among 1011 subjects who developed cancer that self-reported stressful major life events had increased their risk for cancer. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603471
更新日期：2006-12-04 00:00:00
