Abstract:
:To distinguish risk factors for acquisition of cervical human papillomavirus (HPV) infection from the determinants of neoplasia among infected individuals we have conducted a three-arm case-control study nested within a large population-based cohort of women (the Manchester cohort) screened for HPV at entry using L1 consensus primer PCR. The study includes 181 HPV-positive controls who did not develop high-grade cervical intraepithelial neoplasia (CIN3) during follow-up, 203 HPV-negative controls, and 199 HPV-positive cases with histologically confirmed CIN3. Detailed information on sexual, reproductive and gynaecological history, oral contraceptive use and smoking was obtained at face-to-face interview. There was a striking division between risk factors for infection and those predictive of disease. Comparing the HPV-positive against the HPV-negative controls, the only risk factors for infection were number of sexual partners (OR for six or more = 3.89; 95% Cl = 1.99-7.62), a relatively recent new sexual relationship (OR for a new partner within the previous 2 years = 4.17; 95% Cl = 2.13-8.33), and a history of previous miscarriage (OR = 2.59; 95% Cl = 1.28-5.21). The determinants of CIN3 among infected women were, in contrast, early age at first intercourse (OR for 16 years old or less = 3.23; 95% Cl = 1.33-7.69), a long time since starting a new sexual relationship (OR for 6 years or more = 4.94; 95% Cl = 2.51-9.71), and cigarette smoking, with strong evidence for a dose- response (OR for current smoking habit 20+ per day = 2.57; 95% Cl = 1.49-4.45). Oral contraceptive use was not significantly associated with either HPV infection or CIN3.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Deacon JM,Evans CD,Yule R,Desai M,Binns W,Taylor C,Peto Jdoi
10.1054/bjoc.2000.1523subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1565-72issue
11eissn
0007-0920issn
1532-1827pii
S0007092000915234journal_volume
83pub_type
杂志文章abstract::Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...
journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
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pub_type: 已发布勘误
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journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.138
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.709
更新日期:1998-12-01 00:00:00
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journal_title:British journal of cancer
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doi:10.1038/bjc.1997.547
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journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.257
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abstract::Smoking, nutrition, parity and oral contraceptive use have been reported as major environmental risk factors for cervical cancer. After the discovery of the very strong link between human papillomavirus (HPV) infection and cervical cancer, it is unclear whether the association of these environmental factors with cervi...
journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
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