Alterations in serum amino-acid profile in the progression of colorectal cancer: associations with systemic inflammation, tumour stage and patient survival.

abstract：:Advances in understanding the role of vascular endothelial growth factor (VEGF) in normal physiology are giving insight into the basis of adverse effects attributed to the use of VEGF inhibitors in clinical oncology. These effects are typically downstream consequences of suppression of cellular signalling pathways imp...

journal_title：British journal of cancer

authors： Kamba T,McDonald DM

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...

journal_title：British journal of cancer

authors： Ko AH,Tempero MA,Shan YS,Su WC,Lin YL,Dito E,Ong A,Wang YW,Yeh CG,Chen LT

更新日期：2013-08-20 00:00:00

abstract：:Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and a...

journal_title：British journal of cancer

authors： Edwards SC,Hoevenaar WHM,Coffelt SB

更新日期：2021-01-01 00:00:00

abstract：:Acute inflammatory reactions were induced in rats by the intravenous injection of cellulose sulphate (CS) or an extract of normal rat lung homogenate (LH), or by intraperitoneal injections of Compound 48/80. These treatments greatly increased survival and clonogenic growth in the lungs of rats of intravenously injecte...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Stone M,Kelly H,Orton C,Sharpington C

更新日期：1974-09-01 00:00:00

abstract：:Using a panel of ten polymorphic markers, we examined the frequency of loss of heterozygosity (LOH) on chromosome 17 in 55 sporadic ovarian tumours. LOH on 17p and 17q was observed to be 50% and 62% respectively. LOH at D17S5 was detected in 24/36 (67%) of malignant cases and in 19/43 (44%) at TP53; the marker D17S855...

journal_title：British journal of cancer

authors： Papp J,Csokay B,Bosze P,Zalay Z,Toth J,Ponder B,Olah E

更新日期：1996-11-01 00:00:00

abstract：:Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterised by an ability to relocate to another surface following invasio...

journal_title：British journal of cancer

authors： Glynn SA,Gammell P,Heenan M,O'Connor R,Liang Y,Keenan J,Clynes M

更新日期：2004-11-15 00:00:00

abstract：:Initial studies revealed that proline-directed protein kinase F(A) (PDPK F(A)) was overexpressed in various cancerous tissues relative to normal controls. However, the functional role of overexpressed PDPK F(A) in cancer remains to be established. In this report, we explore the potential role of PDPK F(A) in leukaemia...

journal_title：British journal of cancer

authors： Hsu CP,Hsueh SF,Yang CC,Yang SD

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. METHODS:Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine the DKC1 expressio...

journal_title：British journal of cancer

authors： Hou P,Shi P,Jiang T,Yin H,Chu S,Shi M,Bai J,Song J

更新日期：2020-03-01 00:00:00

abstract：:In the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250 mg of FA. 5-MTHF rapidly appeared in plasma, the maximu...

journal_title：British journal of cancer

authors： Thyss A,Milano G,Etienne MC,Paquis P,Roche JL,Grelier P,Schneider M

更新日期：1989-04-01 00:00:00

abstract：:Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...

journal_title：British journal of cancer

authors： Hsieh LL,Shinozuka H,Weinstein IB

更新日期：1991-11-01 00:00:00

abstract：:The accurate determination of exposure to environmental tobacco smoke is notoriously difficult. There have been to date two approaches to determining this exposure in the study of association of passive smoking and lung cancer: the biochemical approach, using cotinine in the main as a marker, and the epidemiological a...

journal_title：British journal of cancer

authors： Tweedie RL,Mengersen KL

更新日期：1992-10-01 00:00:00

abstract：:Monocyte-macrophage series have an important role in host surveillance against cancer. The cytotoxic/cytostatic activity of macrophages is, to a great extent, attributed to the up-regulation of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Here, in 28 patients with primary lung cancer and...

journal_title：British journal of cancer

authors： Liu CY,Wang CH,Chen TC,Lin HC,Yu CT,Kuo HP

更新日期：1998-08-01 00:00:00

abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

journal_title：British journal of cancer

authors： García-Rocha M,García-Gravalos MD,Avila J

更新日期：1996-04-01 00:00:00

abstract：:Recent studies have suggested a correlation between the rate and incidence of apoptosis and the radiation response of particular cell lines. However, we found that increasing the rate of induction of apoptosis in the fibroblast line 208F, by transfecting it with human c-myc, did not lead to a change in its clonogenic ...

journal_title：British journal of cancer

authors： Aldridge DR,Arends MJ,Radford IR

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...

journal_title：British journal of cancer

authors： Iyer R,Gentry-Maharaj A,Nordin A,Burnell M,Liston R,Manchanda R,Das N,Desai R,Gornall R,Beardmore-Gray A,Nevin J,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Varkey S,Olaitan A,Rufford B,Ryan A,Shanbhag

更新日期：2015-02-03 00:00:00

abstract：:The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated anima...

journal_title：British journal of cancer

authors： Mitcheson HD,Sadler TE,Castro JE

更新日期：1980-03-01 00:00:00

abstract：:The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than origi...

journal_title：British journal of cancer

authors： Bader S,Walker M,Harrison D

更新日期：2000-12-01 00:00:00

abstract：:In the search for effective chemotherapy regimens which can be used in multimodality treatment programmes for patients with cancer of the oesophagus, we conducted a phase II trial to determine the activity and toxicity of the combination of cisplatin and etoposide in patients with advanced squamous cell carcinoma of t...

journal_title：British journal of cancer

authors： Kok TC,Van der Gaast A,Dees J,Eykenboom WM,Van Overhagen H,Stoter G,Tilanus HW,Splinter TA

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:Detection of lymph node involvement in women with IB2-IIB cervical cancer could have a positive effect on survival. We set out to evaluate the incidence of pelvic and/or para-aortic lymph node involvement using the sentinel node (SN) biopsy and its impact on survival. METHODS:From 2002 to 2010, 66 women with...

journal_title：British journal of cancer

authors： Chéreau E,Feron JG,Ballester M,Coutant C,Bezu C,Rouzier R,Touboul E,Daraï E

更新日期：2012-01-03 00:00:00

abstract：:In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-c...

journal_title：British journal of cancer

authors： Cragg MS,Zhang L,French RR,Glennie MJ

更新日期：1999-02-01 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Various procedures for immunoprotection in the A-SW mouse SEWA tumour system were compared. Four types of protector agents were used: polyoma virus, allogeneic S724 cells, A9/SEWA hybrid cells and xenogeneic ST(py) cells. Several injection schedules were also employed. On the whole, reasonable immunoprotection was obt...

journal_title：British journal of cancer

authors： Favre R,Carcassonne Y,Meyer G

更新日期：1974-04-01 00:00:00

abstract：BACKGROUND:Men diagnosed with localised prostate cancer (LPC) face difficult choices between treatment options that can cause persistent problems with sexual, urinary and bowel function. Controlled trial evidence about the survival benefits of the full range of treatment alternatives is limited, and patients' views on ...

journal_title：British journal of cancer

authors： King MT,Viney R,Smith DP,Hossain I,Street D,Savage E,Fowler S,Berry MP,Stockler M,Cozzi P,Stricker P,Ward J,Armstrong BK

更新日期：2012-02-14 00:00:00

abstract：:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal a...

journal_title：British journal of cancer

authors： Abnet CC,Freedman ND,Kamangar F,Leitzmann MF,Hollenbeck AR,Schatzkin A

更新日期：2009-02-10 00:00:00

abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...

journal_title：British journal of cancer

authors： Verma Y,Pradhan PK,Gurung N,Sapkota SD,Giri P,Sundas P,Bhattarai BN,Nadayil D,Ramnath T,Nandakumar A

更新日期：2012-02-28 00:00:00

abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...

journal_title：British journal of cancer

authors： Coupland CA,Chilvers CE,Davey G,Pike MC,Oliver RT,Forman D

更新日期：1999-08-01 00:00:00

abstract：:Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemo...

journal_title：British journal of cancer

authors： Hone P,Edwards A,Halls J,Cox R,Lloyd D

更新日期：2003-06-16 00:00:00

abstract：:The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic...

journal_title：British journal of cancer

authors： Sykes E,Woodburn K,Decker D,Kessel D

更新日期：1994-09-01 00:00:00

abstract：:We have examined a series of human colorectal adenomas, carcinomas and cell lines derived from human colorectal cancer for loss of heterozygosity (LOH) on chromosome 11q22-23 by polymerase chain reaction (PCR) amplification of a microsatellite polymorphism of the dopamine D2 receptor (DRD2) locus. LOH was demonstrated...

journal_title：British journal of cancer

authors： Gustafson CE,Young J,Leggett B,Searle J,Chenevix-Trench G

更新日期：1994-09-01 00:00:00

abstract：:Expression of the wild-type p53 gene has an important role in cell differentiation, maturation and apoptosis. Mutation of the p53 gene is associated with tumour development and mutant p53 can promote cell proliferation. Recently wild-type p53 has been demonstrated to exist in two conformational variants: one acting as...

journal_title：British journal of cancer

authors： Zhu YM,Bradbury D,Russell N

更新日期：1993-11-01 00:00:00