Abstract:
:To determine whether resistance to chemoimmunotherapy is acquired during therapy, we investigated the effects of chemotherapeutic agents and anti-tumour polysaccharide, lentinan, on the progression of Rous sarcoma virus-induced S908.D2 fibrosarcomas. The chemoimmunotherapy was effective against the parental S908.D2-bearing mice. Nearly all the mice that were treated with cyclophosphamide (CY) and lentinan achieved complete tumour regression. Only a few of the mice that achieved complete regression of the primary tumours showed a recurrence of the tumour in regional lymph nodes. S908.D2-vp.1 was established from metastatic tumours that developed in the regional lymph nodes of parental S908.D2-bearing mice during therapy. S908.D2-vp.2-or vp.3 cells were sequentially derived in a similar way from S908.D2-vp.1-or-vp.2-bearing mice respectively, in which complete tumour regression at each primary site was achieved during therapy. These lines acquired resistance to CY and lentinan and also to 5-fluorouracil (5-FU)/5'-deoxy-5-fluorouracil and lentinan. No significant difference in either the sensitivity to 5-FU or 4-deoxycyclophosphamide in vitro or in the susceptibility to immune effector cells was observed between the parental and progressed lines (S908.D2-vp1 -vp3). There was an increase in the level of prostaglandin E2 (PGE2) in the progressed lines during repeated therapy (parental, 1171 pg ml(-1); vp.1, 2199 pg ml(-1); vp.2, 5500pg ml(-1); vp3, 16187 pg ml(-1)). There was no significant increase in the production of transforming growth factor beta (TGF-beta). The amount of interleukin-2 (IL-2) produced by spleen cells isolated from the S908.D2-vp.2-bearing mice was decreased compared with the amount produced by the parental S908.D2- bearing mice. Furthermore, combination therapy with lentinan and IL-2 achieved complete tumour regression in all the mice transplanted with S908.D2 progressed tumour lines, although IL-2 alone did not show any anti-tumour effects in either the S908.D2 parental or progressed lines. The findings suggest that the reduced production of IL-2 induced an increase in the production of the PGE2 by progressed tumour lines is involved in the acquisition of resistance.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Hamuro J,Kikuchi T,Takatsuki F,Suzuki Mdoi
10.1038/bjc.1996.82subject
Has Abstractpub_date
1996-02-01 00:00:00pages
465-71issue
4eissn
0007-0920issn
1532-1827journal_volume
73pub_type
杂志文章abstract::A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic cystitis in marrow transplant recipients. Sixty-one consecutive BMT recipients were randomised for treatment with forced di...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1984.252
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:The detection of V600E BRAF mutation in melanoma is fundamental since here BRAF inhibitors represent an effective treatment. Non-V600E BRAF mutations that may also respond are not detected by certain screening methods. Thus, knowledge about detection of these mutations is needed. METHODS:A total of 276 tumo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.143
更新日期:2013-05-28 00:00:00
abstract::Angiopoietin-1 is a promoter of physiological vasculogenesis and angiogenesis because it induces vascular branching and smooth muscle recruitment to newly formed blood vessels. However, angiopoietin-1 expression in tumours appears to be uncommon, and angiopoietin-1 overexpression in cancer cells has been reported to l...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600082
更新日期:2002-02-12 00:00:00
abstract:BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0224-5
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer. METHODS:We analysed data from two case-control studies conducted in Italy between 1983 and 2008, including 362 and 326 pancreatic cancer cases and 1552 and 652 hospital-controls, r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.345
更新日期:2013-09-03 00:00:00
abstract::A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and -negative anal cancers. As part of a population-based case-control study in Denmark and Sweden, we interviewed 4...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.719
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605504
更新日期:2010-02-02 00:00:00
abstract:BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.126
更新日期:2016-06-14 00:00:00
abstract::Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602535
更新日期:2005-04-25 00:00:00
abstract:BACKGROUND:Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic si...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.104
更新日期:2013-04-02 00:00:00
abstract::The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.31
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.184
更新日期:2016-08-09 00:00:00
abstract::Obesity has been associated with an increased risk of renal cell cancer among women, while the evidence for men is considered weaker. We conducted a quantitative summary analysis to evaluate the existing evidence that obesity increases the risk of renal cell cancer both among men and women. We identified all studies e...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1054/bjoc.2001.2040
更新日期:2001-09-28 00:00:00
abstract::The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.60
更新日期:1994-02-01 00:00:00
abstract::In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1580
更新日期:2001-05-18 00:00:00
abstract::Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.344
更新日期:1990-10-01 00:00:00
abstract::The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.34
更新日期:1973-04-01 00:00:00
abstract::The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.183
更新日期:1973-12-01 00:00:00
abstract::Bryostatin 1 is a novel antitumour agent derived from Bugula neritina of the marine phylum Ectoprocta. Nineteen patients with advanced solid tumours were entered into a phase I study to evaluate the toxicity and biological effects of bryostatin 1. Bryostatin 1 was given as a one hour intravenous infusion at the beginn...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1993.352
更新日期:1993-08-01 00:00:00
abstract::Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601240
更新日期:2003-10-06 00:00:00
abstract:BACKGROUND:Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity against systemic (micro)metastatic disease. METHODS:Whole-body magnetic resonance imaging (WB-MRI) was used to monitor the engraftment and dissemination of human...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.356
更新日期:2013-08-06 00:00:00
abstract:BACKGROUND:Gene mutations in the RAS family rule out metastatic colorectal carcinomas (mCRCs) from anti-EGFR therapies. METHODS:We report a retrospective analysis by Sequenom Massarray and fast COLD-PCR followed by Sanger sequencing on 240 mCRCs. RESULTS:By Sequenom, KRAS and NRAS exons 2-3-4 were mutated in 52.9% (1...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.170
更新日期:2017-07-25 00:00:00
abstract:BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.40
更新日期:2013-03-05 00:00:00
abstract::Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604651
更新日期:2008-10-07 00:00:00
abstract::This report presents the results of a study into the effect of breast self-examination (BSE) in a large defined population within the City of Nottingham since 1979. We have examined the effect of breast self-examination in a group of patients invited to attend for education in BSE compared with a group of historical c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.294
更新日期:1989-09-01 00:00:00
abstract::Expression of the wild-type p53 gene has an important role in cell differentiation, maturation and apoptosis. Mutation of the p53 gene is associated with tumour development and mutant p53 can promote cell proliferation. Recently wild-type p53 has been demonstrated to exist in two conformational variants: one acting as...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.444
更新日期:1993-11-01 00:00:00
abstract::To distinguish risk factors for acquisition of cervical human papillomavirus (HPV) infection from the determinants of neoplasia among infected individuals we have conducted a three-arm case-control study nested within a large population-based cohort of women (the Manchester cohort) screened for HPV at entry using L1 c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1523
更新日期:2000-12-01 00:00:00
abstract::The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604949
更新日期:2009-03-24 00:00:00
abstract:BACKGROUND:Activins and inhibins belong to the TGFβ-superfamily, which controls cell proliferation and differentiation in many organs. Activin A, the dimer of inhibin βA subunit, acts strongly anti-proliferative in hepatocytes. Little is known on the other activin/inhibin subunits in human liver and hepatocellular carc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.53
更新日期:2011-04-12 00:00:00
abstract::Information on exposure and reaction to sunlight, together with the history of exposure to fluorescent lighting, was elicited by postal questionnaire. Case-control analysis from 58 patients with malignant melanoma, 182 matched controls and 151 unmatched controls showed associations between malignant melanoma and (i) b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.255
更新日期:1985-11-01 00:00:00