Abstract:
:Extramammary Paget's disease is a particular form of skin cancer of unknown histogenesis. To look for the genetic defects underlying the pathogenesis of this tumour, we have examined loss of heterozygosity (LOH), p53 and human papillomavirus (HPV) status, and the expression of c-erbB-2 and bcl-2 proteins in 14 cases. Unexpectedly, no LOH was detected at several loci commonly lost in other human cancers (namely 3p, 9p, 9q, 13q, 16q, 17p, and 17q) in 12 tumours examined. Altered p53 protein expression was entirely or mostly negative in all 14 cases. Direct sequencing of exons 5-8 of the p53 gene in eight cases revealed no mutation. Polymerase chain reaction amplification of the L1 gene of human papillomavirus (HPV) did not detect the virus that could inactivate p53 and retinoblastoma tumour-suppressor gene products. As expected, c-erbB-2 proto-oncogene protein was overexpressed in six cases. The expression of bcl-2 was negative in all cases. The results presented in this study suggest that molecular events underlying extramammary Paget's disease differ from those of other common epithelial malignancies and that tumour-suppressor genes located in chromosome regions not examined in this study may be important.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Takata M,Hatta N,Takehara Kdoi
10.1038/bjc.1997.482subject
Has Abstractpub_date
1997-01-01 00:00:00pages
904-8issue
7eissn
0007-0920issn
1532-1827journal_volume
76pub_type
杂志文章abstract:BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01049-3
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated. METHODS:Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0815-9
更新日期:2020-06-01 00:00:00
abstract::Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604163
更新日期:2008-01-15 00:00:00
abstract::Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten ot...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.108
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Sindbis virus (SIN) infection causes no or only mild symptoms (fever, rash, and arthralgia) in humans. However, SIN has a strong cytopathic effect (CPE) on various cancer cells. This study focuses on the oncolytic activity of SIN AR399 on oral cancer cells compared with reovirus, a well-known oncolytic virus...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605209
更新日期:2009-08-18 00:00:00
abstract::Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2017.220
更新日期:2017-08-08 00:00:00
abstract:BACKGROUND:This Phase Ib dose-escalating study investigated safety, maximum tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics (PK) and clinical antitumour activity of tosedostat (CHR-2797), an orally bioavailable aminopeptidase inhibitor, in combination with paclitaxel. METHODS:A total of 22 patient...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605917
更新日期:2010-10-26 00:00:00
abstract::Two cell lines (2-10-1 and 8-10-2) derived by exposure to primary tracheal explants to MNNG in vitro were not tumorigenic in syngeneic F-344 rats or athymic BALB/c (nu/nu) mice at early passage, but became tumorigenic at late passage. These cell lines are therefore suited to study the expression of neoantigens during ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.176
更新日期:1981-08-01 00:00:00
abstract::The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.106
更新日期:1975-06-01 00:00:00
abstract::The purpose of this study was to compare the growth-inhibitory effect of cisplatin-paclitaxel with that obtained with a cisplatin-docetaxel combination and to assess the type of interaction. Concomitant use of taxanes and cisplatin was studied in seven human ovarian carcinoma cell lines, using the 96-well plate clonog...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690046
更新日期:1999-01-01 00:00:00
abstract::The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.155
更新日期:1988-07-01 00:00:00
abstract::Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.408
更新日期:1997-01-01 00:00:00
abstract::When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.1998.420
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.107
更新日期:2012-04-24 00:00:00
abstract::The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1167
更新日期:2000-06-01 00:00:00
abstract::Two soft-agar methods for assaying chemosensitivity of human cancers in vitro were compared with respect to colony morphology, plating efficiency (PE) and chemosensitivity of human melanomas. In 9 xenografts and 9 patients' biopsy specimens Method A (essentially that of Courtenay & Mills, 1978) gave considerably highe...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.223
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.201
更新日期:2014-05-13 00:00:00
abstract:BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.535
更新日期:2014-12-09 00:00:00
abstract::Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.302
更新日期:1988-12-01 00:00:00
abstract::The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. The data are studied by statisti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.147
更新日期:1973-09-01 00:00:00
abstract:BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.454
更新日期:2018-02-20 00:00:00
abstract::The risk of ovarian epithelial neoplasia following use of hormonal contraceptives (HC) was examined in data from the Norwegian-Swedish Women's Lifestyle and Health cohort including 103551 women aged 30-49 years in 1991-92. Follow-up through 2000 produced 214 incident cases of histologically confirmed epithelial ovaria...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601715
更新日期:2004-04-05 00:00:00
abstract:BACKGROUND:Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian cancer (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation of choline kinase-alph...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.729
更新日期:2014-01-21 00:00:00
abstract::The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.166
更新日期:1993-05-01 00:00:00
abstract::Women referred to a familial breast cancer clinic completed questionnaires before and after counselling and at annual follow-up to assess their risk estimate and psychological characteristics. The aims were to determine whether those who attended the clinic overestimated their risk or were highly anxious and whether c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690078
更新日期:1999-02-01 00:00:00
abstract::To clarify the prognostic factors in patients with submucosal carcinoma of the oesophagus, we examined the results of surgical treatment for 78 cases over the last decade. The clinicopathological factors including age, sex, location of the tumour, length of the tumour, histological differentiation, subclassification o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1288
更新日期:2000-09-01 00:00:00
abstract::In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.97
更新日期:1988-04-01 00:00:00
abstract::Thymidine incorporation in vitro by remission lymphocytes from a total of 6 patients with acute myeloid leukaemia (AML) was measured following stimulation by autochthonous and allogeneic AML blasts and cell lines. The early peak response to autochthonous blasts in 2 of these patients (48-72 h) is consistent with the c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.81
更新日期:1976-05-01 00:00:00
abstract::The tumour vasculature is vital for the establishment, growth and metastasis of solid tumours. Its physiological properties limit the effectiveness of conventional anti-cancer strategies. Therapeutic approaches directed at the tumour vasculature are reviewed, suggesting the potential of anti-angiogenesis and the targe...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1995.323
更新日期:1995-08-01 00:00:00
abstract::In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603510
更新日期:2007-01-15 00:00:00