A rodent model for testicular involvement in acute lymphoblastic leukaemia.

abstract：:The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...

journal_title：British journal of cancer

authors： Long MG,Boultbee JE,Langley R,Newlands ES,Begent RH,Bagshawe KD

更新日期：1992-11-01 00:00:00

abstract：:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...

journal_title：British journal of cancer

authors： Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris AL

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

journal_title：British journal of cancer

authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

更新日期：2021-01-21 00:00:00

abstract：:Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...

journal_title：British journal of cancer

authors： van Schothorst EM,Mohkamsing S,van Gurp RJ,Oosterhuis JW,van der Saag PT,Looijenga LH

更新日期：1999-07-01 00:00:00

abstract：:The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...

journal_title：British journal of cancer

authors： Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark G

更新日期：1997-01-01 00:00:00

abstract：:We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2,203,500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers ...

journal_title：British journal of cancer

authors： Freedman ND,Schatzkin A,Leitzmann MF,Hollenbeck AR,Abnet CC

更新日期：2007-05-07 00:00:00

abstract：BACKGROUND:To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics...

journal_title：British journal of cancer

authors： Mita AC,Papadopoulos K,de Jonge MJ,Schwartz G,Verweij J,Mita MM,Ricart A,Chu QS,Tolcher AW,Wood L,McCarthy S,Hamilton M,Iwata K,Wacker B,Witt K,Rowinsky EK

更新日期：2011-09-27 00:00:00

abstract：:An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...

journal_title：British journal of cancer

authors： Hamel N,Black MJ,Ghadirian P,Foulkes WD

更新日期：2000-02-01 00:00:00

abstract：:Human papillomavirus (HPV) is thought to cause some vulval squamous cell carcinomas (VSCC) by degrading p53 product. Evidence on whether HPV-negative VSCC results from p53 mutation is conflicting. We performed immunohistochemistry for p53 product on 52 cases of lone vulval intraepithelial neoplasia (VIN), 21 cases of ...

journal_title：British journal of cancer

authors： Rosenthal AN,Hopster D,Ryan A,Jacobs IJ

更新日期：2003-01-27 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...

journal_title：British journal of cancer

authors： Rettenmaier NB,Rettenmaier CR,Wojciechowski T,Abaid LN,Brown JV 3rd,Micha JP,Goldstein BH

更新日期：2010-11-23 00:00:00

abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

journal_title：British journal of cancer

authors： Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

更新日期：1994-04-01 00:00:00

abstract：:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...

journal_title：British journal of cancer

authors： Palmieri G,Cossu A,Ascierto PA,Botti G,Strazzullo M,Lissia A,Colombino M,Casula M,Floris C,Tanda F,Pirastu M,Castello G,Melanoma Cooperative Group.

更新日期：2000-12-01 00:00:00

abstract：:Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomer...

journal_title：British journal of cancer

authors： Cheng AJ,Lin JD,Chang T,Wang TC

更新日期：1998-06-01 00:00:00

abstract：:NIH3T3 cells transfected with c-H-ras and/or c-myc genes were examined for differences in drug sensitivity. The five transfectants used were N8, NIH3T3-nm-1, pT22-3-nm-2, pP1-4 and pT22-3. They were transfected with pKOneo alone, pKOneo and c-myc, pKOneo and c-myc plus activated c-H-ras, normal c-H-ras and activated c...

journal_title：British journal of cancer

authors： Niimi S,Nakagawa K,Yokota J,Tsunokawa Y,Nishio K,Terashima Y,Shibuya M,Terada M,Saijo N

更新日期：1991-02-01 00:00:00

abstract：:Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-spec...

journal_title：British journal of cancer

authors： Gaber A,Johansson M,Stenman UH,Hotakainen K,Pontén F,Glimelius B,Bjartell A,Jirström K,Birgisson H

更新日期：2009-05-19 00:00:00

abstract：:We have studied the ability of cyclosporin A (CsA) and a non-immunosuppressive analogue, O-acetyl cyclosporin A (OACsA, B3-243) to inhibit the growth of human lung cancer cells in vitro. Using continuous drug exposure and the MTT colorimetric assay to determine cell growth we found that CsA produced partial growth inh...

journal_title：British journal of cancer

authors： Twentyman PR,Wright KA,Wallace HM

更新日期：1992-03-01 00:00:00

abstract：:The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wis...

journal_title：British journal of cancer

authors： Curtin NJ,Snell K

更新日期：1983-10-01 00:00:00

abstract：:Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic exposure. Under these hypoxic conditions, glucose consumption and lactate...

journal_title：British journal of cancer

authors： Heacock CS,Sutherland RM

更新日期：1990-08-01 00:00:00

abstract：:An analysis of the occurrence of breast cancer in this long-term prospective cohort study shows a significant relative risk (RR) in women who have ever used oral contraceptives (OC) of 3.33 in women age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in women who were parity 1 at the time of diagnosis. In w...

journal_title：British journal of cancer

authors： Kay CR,Hannaford PC

更新日期：1988-11-01 00:00:00

abstract：:In vivo DNA damage and repair was induced by nicotinamide (NAM) in adenotype 12 virus-induced mouse sarcoma A12B3 and sarcoma F inoculated into CBA mice. DNA damage, NAM and NAD concentrations were measured after in vivo exposure to NAM, in tumours and spleens by alkaline elution and by HPLC analysis. Our results indi...

journal_title：British journal of cancer

authors： Olsson AR,Sheng Y,Pero RW,Chaplin DJ,Horsman MR

更新日期：1996-08-01 00:00:00

abstract：:The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of bracken have also been recognized. Both vegetative tissues and spores of bracken can induce adducts in DNA in animal tissues, but the possible genotoxic or carci...

journal_title：British journal of cancer

authors： Simán SE,Povey AC,Ward TH,Margison GP,Sheffield E

更新日期：2000-07-01 00:00:00

abstract：:Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...

journal_title：British journal of cancer

authors： Hamada J,Cavanaugh PG,Lotan O,Nicolson GL

更新日期：1992-08-01 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：:In the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250 mg of FA. 5-MTHF rapidly appeared in plasma, the maximu...

journal_title：British journal of cancer

authors： Thyss A,Milano G,Etienne MC,Paquis P,Roche JL,Grelier P,Schneider M

更新日期：1989-04-01 00:00:00

abstract：:Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differenc...

journal_title：British journal of cancer

authors： Reeve JG,Wright KA,Twentyman PR

更新日期：1983-06-01 00:00:00

abstract：:Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb/C mice. Time cou...

journal_title：British journal of cancer

authors： Kamm YJ,Peters GJ,Hull WE,Punt CJ,Heerschap A

更新日期：2003-08-18 00:00:00

abstract：:In locally advanced undifferentiated nasopharyngeal carcinoma (UNPC), concomitant chemo-radiotherapy is the only strategy that gave better results over radiation alone in a phase III trial. Adding effective chemotherapy to a concomitant chemo-radiotherapy programme may be a way to improve the results further. 30 patie...

journal_title：British journal of cancer

authors： Benasso M,Sanguineti G,D'Amico M,Corvò R,Ricci I,Numico G,Guarneri D,Vitale V,Pallestrini E,Santelli A,Rosso R

更新日期：2000-12-01 00:00:00

abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...

journal_title：British journal of cancer

authors： Chanudet E,Adam P,Nicholson AG,Wotherspoon AC,Ranaldi R,Goteri G,Pileri SA,Ye H,Müller-Hermelink HK,Du MQ

更新日期：2007-10-08 00:00:00

abstract：:Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed...

journal_title：British journal of cancer

authors： McCall P,Gemmell LK,Mukherjee R,Bartlett JM,Edwards J

更新日期：2008-03-25 00:00:00