Abstract:
:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-positive cases were also bcl-2 positive (28%) compared with 32 of the remaining 80 p53-negative cases (40%). Survival was significantly worse (P = 0.01) in the p53-positive cases. Bcl-2-positive cases, including patients in all Dukes' stages, had a slightly better prognosis which was not statistically significant. However, cases at an early stage (Dukes' stages A and B) and with negative p53 status, had a much better prognosis if they showed bcl-2 protein expression, suggesting that the bcl-2 status itself has an effect on prognosis (P = 0.01). Neither bcl-2 nor p53 alone was correlated with stage, but when examined by both p53 and bcl-2 status a group [bcl-2(+)/p53(-)] with better prognosis was defined. The last group was significantly lower Dukes' stage, with 26 out of 32 cases (81%) being A or B compared with 22 (11%) of the 202 remaining cases (P = 0.004). Thus, either loss of bcl-2 expression or gain of abnormal p53 expression is associated with high stage and poor prognosis. The bcl-2(+)/p53(-) phenotype is similar to that of normal mucosa, and these results suggest that such cases represent an indolent group at an early stage in the progression of colorectal cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris ALdoi
10.1038/bjc.1998.310subject
Has Abstractpub_date
1998-06-01 00:00:00pages
1864-9issue
11eissn
0007-0920issn
1532-1827journal_volume
77pub_type
杂志文章abstract::The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...
journal_title:British journal of cancer
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更新日期:2005-03-28 00:00:00
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journal_title:British journal of cancer
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更新日期:2012-02-14 00:00:00
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pub_type: 杂志文章
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2011-10-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1977-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1995-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6605536
更新日期:2010-02-16 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-26 00:00:00
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journal_title:British journal of cancer
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doi:10.1038/bjc.2014.173
更新日期:2014-05-27 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.252
更新日期:1992-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41416-018-0301-9
更新日期:2019-02-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01049-3
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.317
更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6602260
更新日期:2005-01-31 00:00:00
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1978.1
更新日期:1978-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.68
更新日期:1982-03-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.74
更新日期:1986-04-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.433
更新日期:1995-10-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.310
更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-28 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.90
更新日期:1987-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-01-07 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-26 00:00:00
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journal_title:British journal of cancer
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更新日期:2004-03-22 00:00:00
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journal_title:British journal of cancer
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更新日期:2010-03-16 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00