Abstract：
:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inactivated in familial MM), widely reported data suggested the presence within this region of other melanoma susceptibility gene(s). To clearly assess the role of the 9p21 region in sporadic melanoma, we evaluated the presence of microsatellite instability (MSI) and loss of heterozygosity (LOH) in primary tumours as well as in synchronous or asynchronous metastases obtained from the same MM patients, using 9 polymorphic markers from a 17-cM region at 9p21. LOH and MSI were found in 27 (41%) and 11 (17%), respectively, out of 66 primary tumours analysed. In corresponding 58 metastases, MSI was found at higher rate (22; 38%), whereas a quite identical pattern of allelic deletions with 27 (47%) LOH+ cases were observed. Although the CDKN locus was mostly affected by LOH, an additional region of common allelic deletion corresponding to marker D9S171 was also identified. No significant statistical correlation between any 9p21 genetic alteration (LOH, MSI or both) and clinicopathological parameters was observed.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Palmieri G,Cossu A,Ascierto PA,Botti G,Strazzullo M,Lissia A,Colombino M,Casula M,Floris C,Tanda F,Pirastu M,Castello G,Melanoma Cooperative Group.doi
10.1054/bjoc.2000.1513subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1707-14issue
12eissn
0007-0920issn
1532-1827pii
S0007092000915131journal_volume
83pub_type
杂志文章abstract：:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604819
更新日期：2009-01-13 00:00:00
abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.610
更新日期：2015-01-20 00:00:00
abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...
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pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6605075
更新日期：2009-06-02 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6605685
更新日期：2010-05-25 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601884
更新日期：2004-07-05 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1976.211
更新日期：1976-11-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.363
更新日期：1995-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.411
更新日期：1996-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.285
更新日期：1993-07-01 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6690802
更新日期：1999-11-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.80
更新日期：1994-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.8
更新日期：2017-03-14 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.167
更新日期：1992-05-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.69
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1993.339
更新日期：1993-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1997.511
更新日期：1997-01-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600507
更新日期：2002-09-23 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602465
更新日期：2005-04-11 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1993.122
更新日期：1993-04-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.8
更新日期：1994-01-01 00:00:00
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doi：10.1038/sj.bjc.6690108
更新日期：1999-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1970.11
更新日期：1970-03-01 00:00:00
abstract：:In a longitudinal study of the evolution of serum beta 2-microglobulin (beta 2-m) levels in 37 patients with myelomatosis, those patients with a level of < 4 mg/l at first presentation had a median survival of 46 months, whereas those with an initial level of > mg/l had a median survival of 15 months. THe beta 2-m app...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.273
更新日期：1980-10-01 00:00:00
abstract：BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.126
更新日期：2016-06-14 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1987.303
更新日期：1987-12-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1067
更新日期：2000-03-01 00:00:00
abstract：:Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. T...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.30
更新日期：1975-02-01 00:00:00
abstract：:Mediastinal masses include a wide variety of tumours and remain an interesting diagnostic challenge for radiologist. We performed positron emission tomography (PET) studies of primary mediastinal tumours in order to predict the malignancy of these tumours preoperatively. Twenty-two patients with primary mediastinal tu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.157
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2015.349
更新日期：2015-11-17 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6602383
更新日期：2005-02-28 00:00:00
