Abstract：
:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment of presumptive colorectal, lung, or prostate cancer. Chart abstractions were used to measure nine time intervals; the primary interval was the date of referral for diagnostic assessment to the date the patient was informed of the diagnosis. Health-related quality-of-life (HRQL) was assessed 5 days following the patient being informed of their diagnosis. The median (IQR) time for the primary interval was 71 (30-110), 37 (29-49), and 81 (56-100) days for colorectal, lung, and prostate patients, respectively (Kruskal-Wallis P=0.0001). This interval was significantly less for colorectal patients diagnosed with cancer than for those without cancer (median difference=59.0 days; Wilcoxon P=0.003). No differences in HRQL existed for patients with cancer and those without. Colorectal and prostate patients wait longer between referral for suspected cancer and being informed of their diagnosis than current recommendations. The shorter diagnostic intervals for colorectal patients with cancer suggest clinicians have an effective process for triaging patients referred for diagnostic assessment.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Grunfeld E,Watters JM,Urquhart R,O'Rourke K,Jaffey J,Maziak DE,Morash C,Patel D,Evans WKdoi
10.1038/sj.bjc.6604819subject
Has Abstractpub_date
2009-01-13 00:00:00pages
56-62issue
1eissn
0007-0920issn
1532-1827pii
6604819journal_volume
100pub_type
杂志文章abstract：BACKGROUND:Pre-existing non-cancer conditions may complicate and delay colorectal cancer diagnosis. METHOD:Incident cases (aged ⩾40 years, 2007-2009) with colorectal cancer were identified in the Clinical Practice Research Datalink, UK. Diagnostic interval was defined as time from first symptomatic presentation of col...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.127
更新日期：2017-06-06 00:00:00
abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...
journal_title：British journal of cancer
pub_type： 共识发展会议,杂志文章,评审
doi：10.1038/s41416-019-0653-9
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The community-based incidence of cancer treatment-related long-term consequences is uncertain. We sought to establish the burden of health outcomes that have been associated with treatment among British long-term cancer survivors. METHODS:We identified 26,213 adults from the General Practice Research Databa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.420
更新日期：2011-11-08 00:00:00
abstract：:The zinc finger protein glioma-associated oncogene homologue 1 (Gli-1) is a critical component of the Hedgehog (Hh) signalling pathway, which is essential for morphogenesis and stem-cell renewal, and is dysregulated in many cancer types. As data were not available on the role of Gli-1 expression in oesophageal cancer ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604361
更新日期：2008-05-20 00:00:00
abstract：BACKGROUND:Sindbis virus (SIN) infection causes no or only mild symptoms (fever, rash, and arthralgia) in humans. However, SIN has a strong cytopathic effect (CPE) on various cancer cells. This study focuses on the oncolytic activity of SIN AR399 on oral cancer cells compared with reovirus, a well-known oncolytic virus...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605209
更新日期：2009-08-18 00:00:00
abstract：:An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy d...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6600273
更新日期：2002-06-05 00:00:00
abstract：:Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.31
更新日期：1980-02-01 00:00:00
abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600780
更新日期：2003-02-24 00:00:00
abstract：BACKGROUND:Activating mutations of Fms-like tyrosine kinase 3 (FLT3) constitute a major driver in the pathogenesis of acute myeloid leukaemia (AML). Hence, pharmacological inhibitors of FLT3 are of therapeutic interest for AML. METHODS:The effects of inhibition of FLT3 activity by a novel potent FLT3 inhibitor, BPR1J-...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.564
更新日期：2012-01-31 00:00:00
abstract：:Patients who have no residual invasive cancer following neoadjuvant chemotherapy for breast carcinoma have a better overall survival than those with residual disease. Many classification systems assessing pathological response to neoadjuvant chemotherapy include residual ductal carcinoma in situ (DCIS) only in the def...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602950
更新日期：2006-02-13 00:00:00
abstract：:Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution de...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.252
更新日期：1991-07-01 00:00:00
abstract：:The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, and the age-standardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.47
更新日期：1977-03-01 00:00:00
abstract：:When L2C leukaemic B lymphocytes from guinea-pigs were incubated in vitro with antibody directed to their surface immunoglobulin (Ig), a rapid rise in intracellular adenosine 3':5'-phosphate (cyclic adenosine monophosphate, cAMP) was observed. Estimation of cAMP was by a protein-binding assay using bovine adrenal prot...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.77
更新日期：1979-04-01 00:00:00
abstract：:The production of graft-versus-host (GVH) reactions in (PVGc X Wistar) F1 hybrids by the transfer of PVGc spleen cells resulted in significant resistance of these recipients to a subsequent challenge with the PVGc leukaemia. Protection was markedly dependent on dose and timing of allogeneic cell transfer and was abrog...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.61
更新日期：1976-04-01 00:00:00
abstract：:The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604949
更新日期：2009-03-24 00:00:00
abstract：BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.341
更新日期：2017-12-05 00:00:00
abstract：:The duration of the DNA synthesis period in normal and malignant human tissues from the larynx, trachea bronchus and esophagus of 13 patient has been estimated by a tritiated thymidine, carbon-14 thymidine double-labeling method in vitro. The DNA synthesis times range from approximately 10 to 25 hours, are shortest in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1970.15
更新日期：1970-03-01 00:00:00
abstract：:Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and spec...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604508
更新日期：2008-08-19 00:00:00
abstract：:In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603510
更新日期：2007-01-15 00:00:00
abstract：BACKGROUND:We used bleomycin, etoposide, cisplatin (BEP), the most effective regimen in the treatment of germ cell tumours (GCTs) and increased dose-density by using pegfilgrastim to shorten cycle length. Our aim was to assess safety and tolerability. METHODS:Sixteen male patients with intermediate or poor prognosis m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.309
更新日期：2011-09-06 00:00:00
abstract：BACKGROUND:Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is a key enzyme in ECM remodelling. This study aims to evaluate the prognostic significance of P4HA2 in breast ductal carcinoma in situ (DCIS). METHODS:P4HA2 expression was assessed immunohistochemically in m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0337-x
更新日期：2018-12-01 00:00:00
abstract：:Mutation and overexpression are the main activating mechanisms for the ras family of genes in human cancer and the variable tandem repeat (VTR) located at the 3' end of H-ras has been associated with this risk. In the present study, we have analysed the relative levels of expression of H-ras mRNA in 26 samples of squa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.287
更新日期：1995-07-01 00:00:00
abstract：:Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastas...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.419
更新日期：1991-11-01 00:00:00
abstract：:The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.424
更新日期：1996-09-01 00:00:00
abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690365
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0288-2
更新日期：2018-10-01 00:00:00
abstract：:Heterogeneity of DNA content in multiple hepatocellular carcinomas (HCCs) was investigated by flow cytometry in 62 tumours from 26 patients who had undergone surgical treatment for multiple synchronous HCCs. Heterogeneity of DNA content was defined (a) when tumours had a different DNA ploidy pattern or (b) when the di...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.387
更新日期：1997-01-01 00:00:00
abstract：:Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.40
更新日期：1977-03-01 00:00:00
abstract：:Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12q13-15, whereas well differentiated liposarcomas (WDL) show supernumerary ring and giant marker chromosomes, known to contain amplified 12q sequences. The tight correlation between the presence of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1090
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605963
更新日期：2010-11-23 00:00:00
