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Prostaglandin-like material extracted from squamous carcinomas of the head and neck.

Abstract：

:Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tumours excised within 3 months of radiotherapy and chemotherapy. These amounts correlated with necrosis, inflammation and fibrosis, but not with tumour site, size or degree of differentiation. Most of the prostaglandins formed by these treated tumours thus seem to be associated with host stromal and inflammatory cells, rather than the neoplastic cells. The possible roles of prostaglandins in facilitating the spread of squamous carcinomas are discussed.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Bennett A,Carter RL,Stamford IF,Tanner NS

doi

10.1038/bjc.1980.31

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

204-8

issue

2

eissn

0007-0920

issn

1532-1827

journal_volume

41

pub_type

杂志文章

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