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Detection of human cancer in an animal model using radio-labelled tumour-associated monoclonal antibodies.

Abstract：

:Monoclonal antibodies to epithelial-cell antigenic determinants, labelled with 123I and 125I, were administered parenterally to immunodeficient mice bearing human tumours derived from a human cancer cell line. Anterior, posterior and lateral radioscans of the body were taken with a gamma scintillation camera at various times from immediately to 65 days after injection. Visual displays of the images were processed by standard computer techniques. The model used a human colon-cancer cell line, HT29, and the monoclonal antibody, AUA1, which is specific to an epithelial proliferating antigen. Tumour detection was achieved in all the mice. The smallest tumour detectable appeared to be about 1 mm in diameter. The degree of antibody uptake in a tumour depended on its size and the blood supply of its surrounding tissues We believe that the technology and skills are now available for accurate radioimmunodetection of cancer in man.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Epenetos AA,Nimmon CC,Arklie J,Elliott AT,Hawkins LA,Knowles RW,Britton KE,Bodmer WF

doi

10.1038/bjc.1982.157

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

1-8

issue

1

eissn

0007-0920

issn

1532-1827

journal_volume

46

pub_type

杂志文章

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