Spontaneous shedding and antibody induced modulation of histocompatibility antigens on murine lymphomata: Correlation with metastic capacity.

abstract：:The effects of interferon-alpha (IFN) plus tamoxifen (TMX) in the treatment of advanced breast cancer were assessed. Changes of in vivo biologic determinants including hormone receptors, P24 protein, Ki-67 and growth factor expression were evaluated. Seven patients with advanced, heavily pretreated, breast cancer with...

journal_title：British journal of cancer

authors： Seymour L,Bezwoda WR

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

journal_title：British journal of cancer

authors： Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

更新日期：2012-02-28 00:00:00

abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...

journal_title：British journal of cancer

authors： Freshney RI,Sherry A,Hassanzadah M,Freshney M,Crilly P,Morgan D

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive. METHODS:To delineate the signalling pathways involved i...

journal_title：British journal of cancer

authors： Nguyen CH,Stadler S,Brenner S,Huttary N,Krieger S,Jäger W,Dolznig H,Krupitza G

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...

journal_title：British journal of cancer

authors： Rossi L,Laas E,Mallon P,Vincent-Salomon A,Guinebretiere JM,Lerebours F,Rouzier R,Pierga JY,Reyal F

更新日期：2015-09-29 00:00:00

abstract：:In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...

journal_title：British journal of cancer

authors： Kaaijk P,Troost D,de Boer OJ,Van Amstel P,Bakker PJ,Leenstra S,Bosch DA

更新日期：1996-07-01 00:00:00

abstract：:A cohort study was conducted to investigate the mortality of individuals employed by biological research institutes in the UK. The inclusion criteria were met by 12,703 individuals, of whom 95% were traced (11,502 alive, 395 deaths, 246 embarkations). All-cause mortality was significantly reduced in men (standardised)...

journal_title：British journal of cancer

authors： Brown TP,Paulson J,Pannett B,Coupland C,Coggon D,Chilvers CE,Sasco AJ

更新日期：1996-05-01 00:00:00

abstract：:The efficacy of photodynamic therapy (PDT) using delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) sensitisation and laser light at 635 nm was investigated in the treatment of experimental hepatic tumours. The model of liver tumours was induced either by local inoculation or by administration of tumour...

journal_title：British journal of cancer

authors： Svanberg K,Liu DL,Wang I,Andersson-Engels S,Stenram U,Svanberg S

更新日期：1996-11-01 00:00:00

abstract：:One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intra...

journal_title：British journal of cancer

authors： Edwards JM,Hillier VF,Lawson RA,Moussalli H,Hasleton PS

更新日期：1989-03-01 00:00:00

abstract：:Flunarizine is a class IV calcium channel blocker which increases oxygen delivery to hypoxic regions in solid tumours, exerting a radiosensitising effect in vivo in animal tumour models. Precisely how the drug improves oxygenation is not well understood. We hypothesised that metabolic conditions present within solid t...

journal_title：British journal of cancer

authors： Kavanagh BD,Coffey BE,Needham D,Hochmuth RM,Dewhirst MW

更新日期：1993-04-01 00:00:00

abstract：:Treatment failure in AML is often attributed to P-glycoprotein-associated multidrug resistance. However, the importance of increased DNA repair in resistant cells is becoming more apparent. In order to investigate the ability of the DNA repair inhibitor aphidicolin to modulate drug resistance, we continually exposed b...

journal_title：British journal of cancer

authors： Sargent JM,Elgie AW,Williamson CJ,Lewandowicz GM,Taylor CG

更新日期：2001-03-02 00:00:00

abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...

journal_title：British journal of cancer

authors： Pervin S,Tran L,Urman R,Braga M,Parveen M,Li SA,Chaudhuri G,Singh R

更新日期：2013-03-05 00:00:00

abstract：:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...

journal_title：British journal of cancer

authors： Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Y

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer vaccine trials based on the CT antigens, MAGE-A3 and NY-ESO-1, are being carried out. METHODS:We used specific q-RT-PCR assays to analyse the expression of the CT...

journal_title：British journal of cancer

authors： Dyrskjøt L,Zieger K,Kissow Lildal T,Reinert T,Gruselle O,Coche T,Borre M,Ørntoft TF

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...

journal_title：British journal of cancer

authors： De Stefani E,Boffetta P,Ronco AL,Deneo-Pellegrini H,Correa P,Acosta G,Mendilaharsu M,Luaces ME,Silva C

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:There is growing evidence that history of allergic or autoimmune disease is associated with reduced risk of glioma, but few prospective studies have explored the biological basis. To assess associations with immune conditions and levels of 14 cytokines in serial prediagnostic serum samples, we conducted a st...

journal_title：British journal of cancer

authors： Brenner AV,Inskip PD,Rusiecki J,Rabkin CS,Engels J,Pfeiffer RM

更新日期：2018-10-01 00:00:00

abstract：:Hepatocyte growth factor (HGF), through Met receptor binding, fulfils numerous functions in invasive tumour growth (survival/proliferation, motility, apoptosis), but epigenetic control of gene expression in this process is poorly understood. In HGF-treated breast cancer cells we studied (a) the chemoinvasion towards C...

journal_title：British journal of cancer

authors： Ridolfi E,Matteucci E,Maroni P,Desiderio MA

更新日期：2008-11-18 00:00:00

abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

journal_title：British journal of cancer

authors： Amellem O,Löffler M,Pettersen EO

更新日期：1994-11-01 00:00:00

abstract：:The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...

journal_title：British journal of cancer

authors： Brown JS,Sundar R,Lopez J

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. METHODS:Four-thousand one-hundred and sixty patients enroled in the HD10-HD12 trials underwent HRQoL assessme...

journal_title：British journal of cancer

authors： Behringer K,Müller H,Görgen H,Flechtner HH,Brillant C,Halbsguth TV,Thielen I,Eichenauer DA,Schober T,Nisters-Backes H,Fuchs M,Engert A,Borchmann P

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...

journal_title：British journal of cancer

authors： Matsuoka T,Yashiro M,Nishioka N,Hirakawa K,Olden K,Roberts JD

更新日期：2012-04-24 00:00:00

abstract：:An enzyme activity with the characteristics of reverse transcriptase was detected in marrow from patients with leukaemia in relapse and in firm haematological remission. The endogenous enzyme activities increased following culture, and in remission patients the enzyme activities reached levels equal to or exceeding th...

journal_title：British journal of cancer

authors： Mak TW,Aye MT,Messner H,Sheinin R,Till JE,McCulloch EA

更新日期：1974-06-01 00:00:00

abstract：BACKGROUND:There are currently two million cancer survivors in the United Kingdom, and in recent years this number has grown by 3% per annum. The aim of this paper is to provide long-term projections of cancer prevalence in the United Kingdom. METHODS:National cancer registry data for England were used to estimate can...

journal_title：British journal of cancer

authors： Maddams J,Utley M,Møller H

更新日期：2012-09-25 00:00:00

abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...

journal_title：British journal of cancer

authors： Coupland CA,Chilvers CE,Davey G,Pike MC,Oliver RT,Forman D

更新日期：1999-08-01 00:00:00

abstract：:Heterogeneity of DNA content in multiple hepatocellular carcinomas (HCCs) was investigated by flow cytometry in 62 tumours from 26 patients who had undergone surgical treatment for multiple synchronous HCCs. Heterogeneity of DNA content was defined (a) when tumours had a different DNA ploidy pattern or (b) when the di...

journal_title：British journal of cancer

authors： Hui AM,Kawasaki S,Imamura H,Miyagawa S,Ishii K,Katsuyama T,Makuuchi M

更新日期：1997-01-01 00:00:00

abstract：:A chelating derivative of alpha-melanocyte stimulating hormone (MSH) has been synthesised, in which two molecules of the hormone are cross-linked by diethylenetriamine pentaacetic acid (DTPA). This compound, bisMSH-DTPA, was equipotent with MSH in an in vitro tyrosinase assay with Cloudman S91 melanoma cells. When DBA...

journal_title：British journal of cancer

authors： Bard DR,Knight CG,Page-Thomas DP

更新日期：1990-12-01 00:00:00

abstract：:Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...

journal_title：British journal of cancer

authors： Land EJ,Mukherjee T,Swallow AJ,Bruce JM

更新日期：1985-04-01 00:00:00

abstract：:Thymidine incorporation in vitro by remission lymphocytes from a total of 6 patients with acute myeloid leukaemia (AML) was measured following stimulation by autochthonous and allogeneic AML blasts and cell lines. The early peak response to autochthonous blasts in 2 of these patients (48-72 h) is consistent with the c...

journal_title：British journal of cancer

authors： Taylor GM,Freeman CB,Harris R

更新日期：1976-05-01 00:00:00

abstract：:Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expresse...

journal_title：British journal of cancer

authors： Sivagnanasundaram S,Islam I,Talbot I,Drummond F,Walters JR,Edwards YH

更新日期：2001-01-01 00:00:00

abstract：:Delta-aminolevulinic acid (ALA) is the precursor in the biosynthesis of porphyrins. The knowledge of both the regulation of ALA entrance and efflux from the cells and the control of porphyrin biosynthesis is essential to improve ALA-mediated photodynamic therapy. In this work, we studied the regulation of ALA uptake a...

journal_title：British journal of cancer

authors： Correa García S,Casas A,Perotti C,Batlle A,Bermúdez Moretti M

更新日期：2003-07-07 00:00:00