Abstract：
:A cohort study was conducted to investigate the mortality of individuals employed by biological research institutes in the UK. The inclusion criteria were met by 12,703 individuals, of whom 95% were traced (11,502 alive, 395 deaths, 246 embarkations). All-cause mortality was significantly reduced in men (standardised) mortality ratio (SMR) 55 and women (SMR 52). Mortality was also significantly reduced for circulatory and respiratory diseases, and overall there was low mortality from malignant neoplasms. SMRs exceeded 100, but were not statistically significant, for infective and parasitic diseases. There were no statistically significant raised SMRs for any cancer site. Workers were categorised as ever worked in a laboratory (laboratory workers) and never worked in a laboratory (non-laboratory workers). The all-cause SMR was significantly reduced in both groups, as was mortality from circulatory and respiratory diseases. The SMR for malignant neoplams was also significantly reduced in laboratory workers. On the basis of follow-up to 31 December 1994, there is no evidence of any overall increased risk of mortality in biological research laboratory workers. However, the power of the analysis is limited by the young age of many cohort members and short duration of follow-up. Follow-up is continuing and the data will be reanalysed once more deaths have accumulated.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Brown TP,Paulson J,Pannett B,Coupland C,Coggon D,Chilvers CE,Sasco AJdoi
10.1038/bjc.1996.221subject
Has Abstractpub_date
1996-05-01 00:00:00pages
1152-5issue
9eissn
0007-0920issn
1532-1827journal_volume
73pub_type
杂志文章abstract：BACKGROUND:Cetuximab plus FOLFIRI improved overall survival compared with bevacizumab plus FOLFIRI in KRAS wild-type metastatic colorectal cancer (mCRC) in FIRE-3, but no corresponding benefit was found for progression-free survival. This analysis aimed to determine whether cetuximab improves response and survival vers...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01140-9
更新日期：2020-11-06 00:00:00
abstract：:We examined the association between magnetic field (MF) exposure and survival among children with acute lymphoblastic leukaemia (ALL) treated at 51 Pediatric Oncology Group centres between 1996 and 2001. Of 1672 potentially eligible children under treatment, 482 (29%) participated and personal 24-h MF measurements wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602916
更新日期：2006-01-16 00:00:00
abstract：:The association of endometrial thickness with the risk of developing endometrial cancer (EC) within 2 years was investigated in a consecutive cohort of 1205 breast cancer patients under tamoxifen treatment, undergoing transvaginal ultrasonography (TVUS) for follow-up purpose (asymptomatic, 1068) or for abnormal uterin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600894
更新日期：2003-04-22 00:00:00
abstract：BACKGROUND:Cross-talk between receptor tyrosine kinases and the oestrogen receptor (ER) is implicated in resistance to endocrine therapy. We investigated whether AEE788 (a combined inhibitor of EGFR, HER2 and VEGFR) plus tamoxifen or letrozole enhanced the individual anti-tumour effects of these agents. METHODS:Breast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605641
更新日期：2010-04-13 00:00:00
abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2011.104
更新日期：2011-04-12 00:00:00
abstract：:Our recent genome-wide allelotyping analysis of gallbladder carcinoma identified 3p, 8p, 9q and 22q as chromosomal regions with frequent loss of heterozygosity. The present study was undertaken to more precisely identify the presence and location of regions of frequent allele loss involving those chromosomes in gallbl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600490
更新日期：2002-08-12 00:00:00
abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is associated with poor survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied ANO1, a recently identified calcium-activated chloride channel (CaCC). METHODS:High-resolution genomic and transcriptomic microarray analysis and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605823
更新日期：2010-08-24 00:00:00
abstract：BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0864-0
更新日期：2020-07-01 00:00:00
abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.16
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate pharmacodynamic biomarker...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.456
更新日期：2011-12-06 00:00:00
abstract：:Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.547
更新日期：1997-01-01 00:00:00
abstract：:The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602271
更新日期：2005-01-17 00:00:00
abstract：BACKGROUND:To document the effect of bivalent HPV immunisation on cervical cytology as a screening test and assess the implications of any change, using a retrospective analysis of routinely collected data from the Scottish Cervical Screening Programme (SCSP). METHODS:Data were extracted from the Scottish Cervical Cal...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.474
更新日期：2016-03-01 00:00:00
abstract：:The tolerability, anti-tumour activity and pharmacokinetic interaction of high-dose intravenous cyclosporin combined with intravenous etoposide was evaluated in children. Eighteen patients with recurrent or refractory tumours, all of whom had previously received etoposide, were treated with a combination of high-dose ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1998.383
更新日期：1998-06-01 00:00:00
abstract：:Two hundred and thirteen lung tumours of primary site and 42 metastases were heterotransplanted into nude mice with an overall success rate of 44%. There were differences in success between the histological types. Squamous cell and adenocarcinoma had the highest success rate (51% and 43%, respectively) whereas large c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.29
更新日期：1985-02-01 00:00:00
abstract：:Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0948
更新日期：2000-01-01 00:00:00
abstract：:A urinary gonadotrophin peptide (UGP) was isolated and purified from semi-purified human chorionic gonadotrophin (hCG), prepared from pregnancy urine. The peptide showed hCG-B subunit activity and no hCG-alpha subunit activity as demonstrated by binding studies with the relevant antibodies. It had a molecular weight s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.204
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2016.149
更新日期：2016-06-28 00:00:00
abstract：:Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic exposure. Under these hypoxic conditions, glucose consumption and lactate...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.264
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Enzastaurin, an oral serine-threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS:We analysed the anti-tumour effects of enzastaurin in 22 lun...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.7
更新日期：2012-02-28 00:00:00
abstract：:The nonsteroidal anti-inflammatory drug aspirin and the spice curcumin retard adenoma formation when administered long-term to Apc(Min/+) mice, a model of human familial adenomatous polyposis coli. Both agents interfere with cyclooxygenase activity. When aspirin is administered to Apc(Min/+) mice only postweaning, but...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600900
更新日期：2003-05-06 00:00:00
abstract：:An analysis of the occurrence of breast cancer in this long-term prospective cohort study shows a significant relative risk (RR) in women who have ever used oral contraceptives (OC) of 3.33 in women age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in women who were parity 1 at the time of diagnosis. In w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.285
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhag...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.188
更新日期：2011-06-28 00:00:00
abstract：:This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604348
更新日期：2008-05-06 00:00:00
abstract：:Temozolomide is an oral alkylating agent that readily crosses the blood-brain barrier and has activity in patients with advanced melanoma. Carboplatin is a convenient outpatient treatment that also has activity in patients with melanoma. The purpose of this study was to assess the safety of a combination of temozolomi...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601414
更新日期：2003-11-17 00:00:00
abstract：:Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690685
更新日期：1999-09-01 00:00:00
abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1987.163
更新日期：1987-08-01 00:00:00
abstract：:O6-benzylguanine (O6-BG) and 3-aminobenzamide (3-AB) inhibit the DNA repair proteins O6-alkylguanine-DNA alkyltransferase (AGT) and poly(ADP-ribose) polymerase (PARP) respectively. The effect of O6-BG and/or 3-AB on temozolomide and 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) cytotoxicity, was assessed in seven human tu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.485
更新日期：1996-10-01 00:00:00
abstract：:The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601438
更新日期：2004-01-12 00:00:00
abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1982.138
更新日期：1982-06-01 00:00:00
