ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines.

abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

journal_title：British journal of cancer

authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...

journal_title：British journal of cancer

authors： Thurtle D,Hsu RC,Chetan M,Lophatananon A,Hubbard R,Gnanapragasam VJ,Barrett T

更新日期：2016-11-22 00:00:00

abstract：:beta2-Microglobulin (beta2M), a component of MHC class I molecules, is believed to be associated with tumour status in various cancers. In this study, we examined the expression of beta2M at different malignant stages of oral cavity squamous cell carcinoma (OCSCC). To determine the possible correlation between beta2M ...

journal_title：British journal of cancer

authors： Chen CH,Su CY,Chien CY,Huang CC,Chuang HC,Fang FM,Huang HY,Chen CM,Chiou SJ

更新日期：2008-11-04 00:00:00

abstract：:We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median o...

journal_title：British journal of cancer

authors： Zeleniuch-Jacquotte A,Akhmedkhanov A,Kato I,Koenig KL,Shore RE,Kim MY,Levitz M,Mittal KR,Raju U,Banerjee S,Toniolo P

更新日期：2001-04-06 00:00:00

abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...

journal_title：British journal of cancer

authors： Vasile E,Masi G,Fornaro L,Cupini S,Loupakis F,Bursi S,Petrini I,Di Donato S,Brunetti IM,Ricci S,Antonuzzo A,Chiara S,Amoroso D,Andreuccetti M,Falcone A

更新日期：2009-06-02 00:00:00

abstract：:Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI ...

journal_title：British journal of cancer

authors： Lancashire RJ,Sorahan T,OSCC.

更新日期：2003-04-07 00:00:00

abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...

journal_title：British journal of cancer

authors： Sidebottom E,Clark SR

更新日期：1983-03-01 00:00:00

abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

journal_title：British journal of cancer

authors： Begent RH,Bagshawe KD,Green AJ,Searle F

更新日期：1987-06-01 00:00:00

abstract：:Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

journal_title：British journal of cancer

authors： Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...

journal_title：British journal of cancer

authors： Khanim F,Davies N,Veliça P,Hayden R,Ride J,Pararasa C,Chong MG,Gunther U,Veerapen N,Winn P,Farmer R,Trivier E,Rigoreau L,Drayson M,Bunce C

更新日期：2014-03-18 00:00:00

abstract：:The evidence base for head and neck cancers is low with relatively few randomized controlled trials of the two main treatments, surgery and radiotherapy. The aim of the study was to investigate the patterns of surgery and radiotherapy treatment for head and neck cancers in three large areas of England and to investiga...

journal_title：British journal of cancer

authors： Edwards DM,Johnson NW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Wnt-signalling has an important role in renal cancer and it is modulated by genistein in other cancers. Recently, microRNAs (miRNAs) have emerged as new regulators of gene expression. Thus, we focused on miRNAs to examine the regulatory mechanism of genistein on the Wnt-signalling pathway in renal cell carci...

journal_title：British journal of cancer

authors： Hirata H,Ueno K,Nakajima K,Tabatabai ZL,Hinoda Y,Ishii N,Dahiya R

更新日期：2013-05-28 00:00:00

abstract：:Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may c...

journal_title：British journal of cancer

authors： Forsyth PA,Wong H,Laing TD,Rewcastle NB,Morris DG,Muzik H,Leco KJ,Johnston RN,Brasher PM,Sutherland G,Edwards DR

更新日期：1999-04-01 00:00:00

abstract：:6-Mercaptopurine (MP)-sensitive and -resistant cell culture lines were used to further characterize the apparent ability of MP nucleotide derivatives to overcome resistance to the parent drug. 6-Mercaptopurine-9-beta-D-ribofuranoside 5'-monophosphate [MPRP], bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5', 5"'-monoph...

journal_title：British journal of cancer

authors： Johnston HP,Hawley P,White SE,Gibson I,Tidd DM

更新日期：1985-04-01 00:00:00

abstract：:The multivariate lognormal survival model can be used to determine the relationship of prognostic covariates to two important parameters of malignancy. Cured fraction and median survival time among uncured patients. Analysis with this model revealed that cured fraction is primarily a function of histologic type and no...

journal_title：British journal of cancer

authors： Gamel JW,Jones AS

更新日期：1993-05-01 00:00:00

abstract：:Endocrine therapy is a recognised option in the treatment of chemo-resistant ovarian cancer. We conducted a nonrandomised phase II evaluation of combination endocrine therapy with tamoxifen and goserelin in patients with advanced ovarian cancer that had recurred following chemotherapy. In total, 26 patients entered th...

journal_title：British journal of cancer

authors： Hasan J,Ton N,Mullamitha S,Clamp A,McNeilly A,Marshall E,Jayson GC

更新日期：2005-09-19 00:00:00

abstract：:Pancreatic cancer is characterised by a hallmark desmoplastic response that includes upregulated expression of the extracellular matrix, and type I collagen in particular. Recent studies indicate that pancreatic cancer cells stimulate type I collagen synthesis in adjacent stellate cells, and that this upregulated type...

journal_title：British journal of cancer

authors： Grzesiak JJ,Bouvet M

更新日期：2006-05-08 00:00:00

abstract：:Antibodies to the tumour-specific transplantation type antigen (TSTA) of a transplanted methylcholanthrene-induced sarcoma (MC-1) in syngeneic rats were studied using the techniques of indirect membrane immunofluorescence and mixed haemadsorption with a (51)Cr-labelled indicator cell. After tumour excision, anti-TSTA ...

journal_title：British journal of cancer

authors： Thomson DM,Steele K,Alexander P

更新日期：1973-01-01 00:00:00

abstract：BACKGROUND:Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS:We used 1H magnetic resonance spe...

journal_title：British journal of cancer

authors： Lee SH,McIntyre D,Honess D,Hulikova A,Pacheco-Torres J,Cerdán S,Swietach P,Harris AL,Griffiths JR

更新日期：2018-08-01 00:00:00

abstract：:We investigated the feasibility and the anti-tumour activity of weekly cisplatin and the simultaneous application of local hyperthermia in patients with a pelvic recurrence of cervical cancer in previously irradiated area. Dose levels of cisplatin 60 mg m(-2), 70 mg m(-2) and 80 mg m(-2) were studied. Treatment object...

journal_title：British journal of cancer

authors： de Wit R,van der Zee J,van der Burg ME,Kruit WH,Logmans A,van Rhoon GC,Verweij J

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. We evaluated the prognostic significance of candidate cytokines and angiogenic factors (CAFs) identified in ...

journal_title：British journal of cancer

authors： Zurita AJ,Gagnon RC,Liu Y,Tran HT,Figlin RA,Hutson TE,D'Amelio AM Jr,Sternberg CN,Pandite LN,Heymach JV

更新日期：2017-08-08 00:00:00

abstract：:The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results d...

journal_title：British journal of cancer

authors： De Ruyck K,de Gelder V,Van Eijkeren M,Boterberg T,De Neve W,Vral A,Thierens H

更新日期：2008-05-20 00:00:00

abstract：:Previous studies have shown that multidrug resistance (MDR) in the doxorubicin-selected lung tumour cell lines COR-L23/R, GLC4/ADR and MOR/R is associated with overexpression of the MRP gene. In this study we report that resistance to daunorubicin, vincristine and rhodamine 123 can be partially reversed in these cell ...

journal_title：British journal of cancer

authors： Versantvoort CH,Broxterman HJ,Bagrij T,Scheper RJ,Twentyman PR

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation to risk of colorectal cancer in primary care. METHODS:Diagnostic accuracy systematic review. Medline (19...

journal_title：British journal of cancer

authors： Olde Bekkink M,McCowan C,Falk GA,Teljeur C,Van de Laar FA,Fahey T

更新日期：2010-01-05 00:00:00

abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...

journal_title：British journal of cancer

authors： Noci I,Borri P,Bonfirraro G,Chieffi O,Arcangeli A,Cherubini A,Dabizzi S,Buccoliero AM,Paglierani M,Taddei GL

更新日期：2001-08-03 00:00:00

abstract：:The role of two common polymorphisms of enzymes involved in the metabolism of drugs and carcinogens was studied in relation to prostate cancer. The gene encoding one of these enzymes (NAT2) is located in an area where frequent allelic loss occurs in prostate cancer. Mutations at the genes CYP2D6 and NAT2 were analysed...

journal_title：British journal of cancer

authors： Agúndez JA,Martínez C,Olivera M,Gallardo L,Ladero JM,Rosado C,Prados J,Rodriguez-Molina J,Resel L,Benítez J

更新日期：1998-11-01 00:00:00

abstract：:Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...

journal_title：British journal of cancer

authors： Din FV,Dunlop MG,Stark LA

更新日期：2004-07-19 00:00:00

abstract：:PS2, an oestrogen-inducible protein, was measured in the cytosol of 230 primary tumours from patients who were subjected to first-line tamoxifen therapy for advanced disease without prior adjuvant therapy with tamoxifen. PS2 correlated positively with oestrogen receptor (ER, P < 0.01) and progesterone receptor content...

journal_title：British journal of cancer

authors： Foekens JA,Portengen H,Look MP,van Putten WL,Thirion B,Bontenbal M,Klijn JG

更新日期：1994-12-01 00:00:00

abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

journal_title：British journal of cancer

authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

更新日期：1998-09-01 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2004-01-12 00:00:00