Abstract:
:The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, diagnosed between 1992 and mid-1998 (N=1197), were identified using the Saskatchewan Cancer Agency cancer registry. Women >/=50 years of age, eligible for coverage by the Saskatchewan Prescription Drug Plan, were included in the study. Four controls per case were age matched to cases, using incidence density sampling. The outpatient prescription drug plan database was used to ascertain oestrogen prescriptions. Women were classified according to history of transdermal (TDE) and oral (OE) oestrogen use. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Compared with women who had never used HRT, ORs for <3 and >/=3 years of TDE use and colorectal cancer were 0.69 (95% CI: 0.43-1.10) and 0.33 (95% CI: 0.12-0.95), and for OE use were 0.90 (95% CI: 0.73-1.01) and 0.75 (95% CI: 0.60-0.93), respectively. The risk reduction for colorectal cancer with TDE may be greater in magnitude than that which has been reported for oral HRT.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Csizmadi I,Collet JP,Benedetti A,Boivin JF,Hanley JAdoi
10.1038/sj.bjc.6601438subject
Has Abstractpub_date
2004-01-12 00:00:00pages
76-81issue
1eissn
0007-0920issn
1532-1827pii
6601438journal_volume
90pub_type
杂志文章abstract::There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2015
更新日期:2001-09-14 00:00:00
abstract::Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1998.578
更新日期:1998-09-01 00:00:00
abstract::Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple numerical or structural...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.312
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0288-2
更新日期:2018-10-01 00:00:00
abstract::Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.192
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contains crucial information about tumour heterogeneity and the transport limitations that reduce drug efficacy. Mathematical modelling of drug delivery and cellular responsiveness based on underutilised DCE-MRI data has the unique potential to p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605773
更新日期:2010-08-10 00:00:00
abstract::The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1167
更新日期:2000-06-01 00:00:00
abstract::We reviewed 134 patients with breast cancer (screen detected = 85, interval = 49) who had been reported as negative at previous mammographic screening in the Florence District Programme. At prior mammograms review, 12% of the cases were classified as 'screening error' (suspicious signs missed owing to misperception or...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.67
更新日期:1995-02-01 00:00:00
abstract::Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600590
更新日期:2002-11-18 00:00:00
abstract:BACKGROUND:Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric canc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.235
更新日期:2012-06-26 00:00:00
abstract::The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations in colorectal cancer affect the accuracy of circulating angiogenic factors as predictors of colorectal cancer vascularity is unknown. We used enzyme-linked immunosorbant assay to measure plasma vascular ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1033
更新日期:2000-03-01 00:00:00
abstract::Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.74
更新日期:1985-04-01 00:00:00
abstract::Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6604213
更新日期:2008-03-11 00:00:00
abstract::Oesophageal adenocarcinoma is believed to arise from metaplastic mucosa in the distal oesophagus, a condition also known as Barrett's oesophagus (BE). BE develops as a result of injury caused by refluxing gastric and duodenal contents and is associated with increased risk of malignant transformation. Matrix metallopro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1929
更新日期:2001-08-03 00:00:00
abstract:BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.454
更新日期:2018-02-20 00:00:00
abstract::A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.421
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0580-9
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605258
更新日期:2009-09-15 00:00:00
abstract::This corrects the article DOI: 10.1038/bjc.2017.327. ...
journal_title:British journal of cancer
pub_type: 杂志文章,已发布勘误
doi:10.1038/bjc.2017.438
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0081-2
更新日期:2018-06-01 00:00:00
abstract::Circulating anti-p53 antibodies have been described and used as tumoural markers in patients with various cancers and strongly correlate with the p53 mutated status of the tumours. No study has yet looked at the prevalence of such antibodies in skin carcinoma patients although these tumours have been shown to be frequ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2185
更新日期:2001-12-14 00:00:00
abstract:BACKGROUND:Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiting medication, on tim...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605800
更新日期:2010-09-07 00:00:00
abstract:BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.341
更新日期:2017-12-05 00:00:00
abstract::High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604756
更新日期:2008-12-02 00:00:00
abstract::More women are living with and surviving breast cancer, because of improvements in breast cancer care. Trastuzumab (Herceptin) has significantly improved outcomes for women with HER2-positive tumours. Concerns about the cardiac effects of trastuzumab (which fundamentally differ from the permanent myocyte loss associat...
journal_title:British journal of cancer
pub_type: 杂志文章,实务指引
doi:10.1038/sj.bjc.6604909
更新日期:2009-03-10 00:00:00
abstract:INTRODUCTION:This paper reports on an ongoing primary care audit of cancer referrals undertaken in Scotland in 2006-2007 and 2007-2008. METHODS:General practitioners (GPs) in Scotland were asked to review all new cancer diagnoses within their practice during the preceding year. RESULTS:4181 patients were identified i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605397
更新日期:2009-12-03 00:00:00
abstract::The in vitro metabolisms of [14C]7,12-dimethylbenz(a)anthracene (DMBA) by post-mitochondrial supernates and microsomes from intact and regenerating rat livers were compared. Both cell fractions from regenerating livers at 48, 72, and 96 h after partial hepatectomy metabolized less [14C]DMBA than similar fractions from...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.112
更新日期:1977-06-01 00:00:00
abstract::We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.89
更新日期:1998-02-01 00:00:00
abstract::The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.605
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients. METHODS:PRIMA-1...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.635
更新日期:2013-11-12 00:00:00