Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.

abstract：:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...

journal_title：British journal of cancer

authors： Harbeck N,Untch M,Pache L,Eiermann W

更新日期：1994-03-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) prognosis is strictly related to well-established clinicopathological parameters which have unfortunately become insufficient in the prognostic evaluation of this type of cancer. As p53 and bcl-2 gene deregulations are frequently involved in several types of epithelial malignancies, ...

journal_title：British journal of cancer

authors： Fontanini G,Vignati S,Bigini D,Mussi A,Lucchi M,Angeletti CA,Basolo F,Bevilacqua G

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：:A study was conducted on the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on peroxisomal enzyme activities in mouse embryo fibroblasts C3H/10T1/2 C18 cells and chemically transformed C3H/10T1/2 MCA16 cells. TPA is a potent tumour promoter and treatment with this compound of the two cell lines induced peroxis...

journal_title：British journal of cancer

authors： Lillehaug JR,Berge RK

更新日期：1986-01-01 00:00:00

abstract：:The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child's immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprisi...

journal_title：British journal of cancer

authors： Schüz J,Kaletsch U,Meinert R,Kaatsch P,Michaelis J

更新日期：1999-05-01 00:00:00

abstract：:5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that...

journal_title：British journal of cancer

authors： Ramu A,Glaubiger D,Soprey P,Reaman GH,Feuerstein N

更新日期：1984-04-01 00:00:00

abstract：:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attend...

journal_title：British journal of cancer

authors： Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...

journal_title：British journal of cancer

authors： Edwards SM,Evans DG,Hope Q,Norman AR,Barbachano Y,Bullock S,Kote-Jarai Z,Meitz J,Falconer A,Osin P,Fisher C,Guy M,Jhavar SG,Hall AL,O'Brien LT,Gehr-Swain BN,Wilkinson RA,Forrest MS,Dearnaley DP,Ardern-Jones AT,Pag

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...

journal_title：British journal of cancer

authors： Sahebjam S,Aloyz R,Pilavdzic D,Brisson ML,Ferrario C,Bouganim N,Cohen V,Miller WH Jr,Panasci LC

更新日期：2011-10-25 00:00:00

abstract：:Chemotherapy or radiotherapy often cause mucosal damage in the gut (gut mucositis) in cancer patients. As a step to investigate mechanisms underlying subsequent intestinal repair, we have examined the expression profiles of hepatocyte growth factor (HGF) and its receptor c-met, two molecules previously implicated in t...

journal_title：British journal of cancer

authors： Xian CJ,Couper R,Howarth GS,Read LC,Kallincos NC

更新日期：2000-02-01 00:00:00

abstract：:The purpose of the study was to evaluate the influence of baseline haemoglobin level in predicting response to 5-fluorouracil (5FU)-based first-line chemotherapy in advanced colorectal cancer patients. Data from 631 patients were collected from three different institutions. Globally, overall response rate was 35.8% (2...

journal_title：British journal of cancer

authors： Tampellini M,Saini A,Alabiso I,Bitossi R,Brizzi MP,Sculli CM,Berruti A,Gorzegno G,Magnino A,Sperti E,Miraglia S,Forti L,Alabiso O,Aglietta M,Harris A,Dogliotti L

更新日期：2006-07-03 00:00:00

abstract：:Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-kappaB (NF-kappaB). Both iNOS activation and radioresponse were impaired by the NF-kappaB inhibitors phenylarsin...

journal_title：British journal of cancer

authors： De Ridder M,Van den Berge DL,Verovski VN,Monsaert C,Wauters N,Storme GA

更新日期：2003-01-13 00:00:00

abstract：BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...

journal_title：British journal of cancer

authors： Bendifallah S,Uzan C,Fauvet R,Morice P,Darai E

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy. ME...

journal_title：British journal of cancer

authors： Kriege M,Hollestelle A,Jager A,Huijts PE,Berns EM,Sieuwerts AM,Meijer-van Gelder ME,Collée JM,Devilee P,Hooning MJ,Martens JW,Seynaeve C

更新日期：2014-08-26 00:00:00

abstract：:Metastasis of colorectal carcinomas rarely occurs in cirrhotic livers. Our study investigated the influence of activated Kupffer cells from cirrhotic rat livers on hepatic colonization and FasR-mediated apoptosis of colon cancer cells. A rat colon cancer cell line, RCN-9, was used to inoculate rat livers. Treatment wi...

journal_title：British journal of cancer

authors： Song E,Chen J,Ouyang N,Wang M,Exton MS,Heemann U

更新日期：2001-05-04 00:00:00

abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...

journal_title：British journal of cancer

authors： Ohradanova A,Gradin K,Barathova M,Zatovicova M,Holotnakova T,Kopacek J,Parkkila S,Poellinger L,Pastorekova S,Pastorek J

更新日期：2008-10-21 00:00:00

abstract：:Oesopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumours of the upper aero-digestive tract and the oesophagus. In this study, we compared cytological evaluation and molecular analysis for the detection of exfoliated cancer cells sampled with an OPB. A total of ...

journal_title：British journal of cancer

authors： Temam S,Trassard M,Leroux G,Bosq J,Luboinski B,Lenoir G,Bénard J,Janot F

更新日期：2003-06-02 00:00:00

abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...

journal_title：British journal of cancer

authors： Konecny GE,Glas R,Dering J,Manivong K,Qi J,Finn RS,Yang GR,Hong KL,Ginther C,Winterhoff B,Gao G,Brugge J,Slamon DJ

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:The conventional treatment options for advanced gastric patients remain unsatisfactory in terms of response rate, response duration, toxicity, and overall survival benefit. The purpose of this phase II study was to evaluate the activity and safety of cetuximab combined with cisplatin and docetaxel as a first...

journal_title：British journal of cancer

authors： Pinto C,Di Fabio F,Barone C,Siena S,Falcone A,Cascinu S,Rojas Llimpe FL,Stella G,Schinzari G,Artale S,Mutri V,Giaquinta S,Giannetta L,Bardelli A,Martoni AA

更新日期：2009-10-20 00:00:00

abstract：:Complex biological pathways including angiogenesis, invasion, osteoclastic activation and bone matrix degradation are involved in the formation of bone metastasis (BM). The aim of our study was to investigate the cross-sectional and longitudinal associations of a panel of 12 serum biochemical markers reflecting biolog...

journal_title：British journal of cancer

authors： Voorzanger-Rousselot N,Juillet F,Mareau E,Zimmermann J,Kalebic T,Garnero P

更新日期：2006-08-21 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：:Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001...

journal_title：British journal of cancer

authors： Key TJ,Chen J,Wang DY,Pike MC,Boreham J

更新日期：1990-10-01 00:00:00

abstract：:The purpose of the study was to determine the response rates (RR) and duration to second- and third-line chemotherapy programmes in patients with anthracycline-resistant breast cancer, utilizing various definitions of anthracycline resistance. This was a retrospective analysis performed on 1335 patients with metastati...

journal_title：British journal of cancer

authors： Pivot X,Asmar L,Buzdar AU,Valero V,Hortobagyi G

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...

journal_title：British journal of cancer

authors： Shamash J,Powles T,Sarker SJ,Protheroe A,Mithal N,Mills R,Beard R,Wilson P,Tranter N,O'Brien N,McFaul S,Oliver T

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca2+-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is oncogenic and overexpressed...

journal_title：British journal of cancer

authors： James AD,Richardson DA,Oh IW,Sritangos P,Attard T,Barrett L,Bruce JIE

更新日期：2020-01-01 00:00:00

abstract：:The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...

journal_title：British journal of cancer

authors： Brown JS,Sundar R,Lopez J

更新日期：2018-02-06 00:00:00

abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...

journal_title：British journal of cancer

authors： Løvig T,Andersen SN,Thorstensen L,Diep CB,Meling GI,Lothe RA,Rognum TO

更新日期：2002-09-23 00:00:00

abstract：BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...

journal_title：British journal of cancer

authors： Basanta D,Scott JG,Fishman MN,Ayala G,Hayward SW,Anderson AR

更新日期：2012-01-03 00:00:00

abstract：:Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ an...

journal_title：British journal of cancer

authors： Kadagidze ZG,Tupitsyn NN,Baryshnikov AJ,Kadyrov KP,Blinov VM,Bernard A,Amiot M,Boumsell L

更新日期：1990-02-01 00:00:00

abstract：:Findings in humans and animal models suggest that in utero hormonal and dietary exposures increase later breast cancer risk. Since alcohol intake by adult women consistently increases their breast cancer risk, we wondered whether maternal alcohol consumption during pregnancy increases female offspring's mammary tumori...

journal_title：British journal of cancer

authors： Hilakivi-Clarke L,Cabanes A,de Assis S,Wang M,Khan G,Shoemaker WJ,Stevens RG

更新日期：2004-06-01 00:00:00