Familial breast cancer: a controlled study of risk perception, psychological morbidity and health beliefs in women attending for genetic counselling.

Abstract:

:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attending the Royal Marsden and Mayday University Hospital genetic counselling services and 62 matched GP attenders (controls). Levels of general psychological morbidity were found to be similar between cases and controls; however, cases reported significantly higher breast cancer-specific distress despite clinic attendance [mean (s.d.) total Impact of Event Scale score, 14.1 (14.3) cases; 2.4 (6.7) controls, P < 0.001]. Although cases perceived themselves to be more susceptible to breast cancer, many women failed correctly to recall risk figures provided by the clinic; 66% could not accurately recall their own lifetime chance. Clinics appeared to have a positive impact on preventive behaviours and cases tended to engage more regularly in breast self-examination (monthly, 66% of cases vs 47% of controls), although few differences were found between groups in terms of health beliefs. We conclude that counselees and GP controls showed considerable similarities on many of the outcome measures, and risk of breast cancer was not predictive of greater psychological morbidity; although cases were more vulnerable to cancer-specific distress. Despite genetic counselling, many cases continued to perceive their risk of breast cancer inaccurately.

journal_name

Br J Cancer

authors

Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

doi

10.1038/bjc.1996.387

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

482-7

issue

3

eissn

0007-0920

issn

1532-1827

journal_volume

74

pub_type

杂志文章
  • An examination of the initial cancer consultation of medical and radiation oncologists using the Cancode interaction analysis system.

    abstract::This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604348

    authors: Dimoska A,Butow PN,Dent E,Arnold B,Brown RF,Tattersall MH

    更新日期:2008-05-06 00:00:00

  • Catalase depression in malignant liver from chickens with myeloblastosis and Marek's disease.

    abstract::In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1984.189

    authors: Williams-Smith DL,Payne LN,Wyard SJ

    更新日期:1984-09-01 00:00:00

  • A preliminary study of intravenous methanol extraction residue of BCG in treatment of advanced cancer.

    abstract::Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/bjc.1977.198

    authors: Robinson E,Bartal A,Honigman J,Cohen Y

    更新日期:1977-09-01 00:00:00

  • Cisplatin and vinorelbine followed by ifosfamide plus epirubicin vs the opposite sequence in advanced unresectable stage III and metastatic stage IV non-small-cell lung cancer: a prospective randomized study of the Southern Italy Oncology Group (GOIM).

    abstract::A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1038/bjc.1997.586

    authors: Colucci G,Gebbia V,Galetta D,Riccardi F,Cariello S,Gebbia N

    更新日期:1997-01-01 00:00:00

  • Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma.

    abstract:BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TII...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-019-0622-3

    authors: Hatogai K,Fujii S,Kitano S,Kojima T,Daiko H,Yoshino T,Ohtsu A,Takiguchi Y,Doi T,Ochiai A

    更新日期:2020-02-01 00:00:00

  • Improving survival in recurrent medulloblastoma: earlier detection, better treatment or still an impasse?

    abstract::Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1038/bjc.1998.220

    authors: Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

    更新日期:1998-04-01 00:00:00

  • Carboplatin, ifosfamide and etoposide with mid-course vincristine and thoracic radiotherapy for 'limited' stage small cell carcinoma of the bronchus.

    abstract::Forty-two patients with small cell lung cancer were treated with a combination of carboplatin, ifosfamide and etoposide. Vincristine was given on day 14 of each course, the courses being repeated every 28 days for a maximum of six. Thoracic radiotherapy was given 4 weeks after the last course of chemotherapy but no pr...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1989.228

    authors: Thatcher N,Lind M,Stout R,Payne C,Carroll KB,Campbell C,Moussalli H

    更新日期:1989-07-01 00:00:00

  • Context-dependent effects of cellular senescence in cancer development.

    abstract::Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/bjc.2016.115

    authors: Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

    更新日期:2016-05-24 00:00:00

  • Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity.

    abstract::Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1987.119

    authors: Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

    更新日期:1987-06-01 00:00:00

  • Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany.

    abstract::Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically conf...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604066

    authors: Hoffmeister M,Raum E,Winter J,Chang-Claude J,Brenner H

    更新日期:2007-12-03 00:00:00

  • Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.

    abstract::Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6690323

    authors: Wang ZJ,Churchman M,Campbell IG,Xu WH,Yan ZY,McCluggage WG,Foulkes WD,Tomlinson IP

    更新日期:1999-04-01 00:00:00

  • A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer.

    abstract:BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1038/bjc.2013.408

    authors: Ko AH,Tempero MA,Shan YS,Su WC,Lin YL,Dito E,Ong A,Wang YW,Yeh CG,Chen LT

    更新日期:2013-08-20 00:00:00

  • A study of guanidinobenzoatase during development of mesothelioma induced in the rat by fibrous erionite.

    abstract::Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1988.269

    authors: Steven FS,Hill RJ

    更新日期:1988-11-01 00:00:00

  • A phase II randomised clinical trial comparing cisplatin, paclitaxel and ifosfamide with cisplatin, paclitaxel and epirubicin in newly diagnosed advanced epithelial ovarian cancer: long-term survival analysis.

    abstract::To test the feasibility and efficacy of epirubicin and ifosfamide added to first-line chemotherapy with cisplatin and paclitaxel in a phase II randomised clinical trial. Patients with histologically proven epithelial ovarian cancer were randomly assigned to receive first-line polychemotherapy with cisplatin/paclitaxel...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1038/sj.bjc.6604231

    authors: Fruscio R,Colombo N,Lissoni AA,Garbi A,Fossati R,Ieda' N,Torri V,Mangioni C

    更新日期:2008-02-26 00:00:00

  • Aspirin as a neoadjuvant agent during preoperative chemoradiation for rectal cancer.

    abstract:BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2015.336

    authors: Restivo A,Cocco IM,Casula G,Scintu F,Cabras F,Scartozzi M,Zorcolo L

    更新日期:2015-10-20 00:00:00

  • The relationship between weight loss and interleukin 6 in non-small-cell lung cancer.

    abstract::Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.294

    authors: Scott HR,McMillan DC,Crilly A,McArdle CS,Milroy R

    更新日期:1996-06-01 00:00:00

  • MAL promoter hypermethylation as a novel prognostic marker in gastric cancer.

    abstract::T-lymphocyte maturation associated protein, MAL, has been described as a tumour-suppressor gene with diagnostic value in colorectal and oesophageal cancers, and can be inactivated by promoter hypermethylation. The aim of this study was to analyse the prevalence of MAL promoter hypermethylation and the association with...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604777

    authors: Buffart TE,Overmeer RM,Steenbergen RD,Tijssen M,van Grieken NC,Snijders PJ,Grabsch HI,van de Velde CJ,Carvalho B,Meijer GA

    更新日期:2008-12-02 00:00:00

  • A rodent model for testicular involvement in acute lymphoblastic leukaemia.

    abstract::The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1993.166

    authors: Jahnukainen K,Morris I,Roe S,Salmi TT,Mäkipernaa A,Pöllänen P

    更新日期:1993-05-01 00:00:00

  • Oestrogen-receptor status and sites of metastasis in breast cancer.

    abstract::The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1981.205

    authors: Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

    更新日期:1981-09-01 00:00:00

  • Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer.

    abstract::HMGI-C belongs to the high-mobility-group-protein (HMG) family of architectural transcription factors and considerable interest has recently been shown in its expression in neoplastic tissues and apparent involvement in tumorigenesis. We could previously demonstrate an expression of HMGI-C mRNA in the peripheral blood...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6600935

    authors: Langelotz C,Schmid P,Jakob C,Heider U,Wernecke KD,Possinger K,Sezer O

    更新日期:2003-05-06 00:00:00

  • Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line.

    abstract::Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.2000.1363

    authors: Tokunaga T,Tsuchida T,Kijima H,Okamoto K,Oshika Y,Sawa N,Ohnishi Y,Yamazaki H,Miura S,Ueyama Y,Nakamura M

    更新日期:2000-09-01 00:00:00

  • Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up.

    abstract::We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1994.103

    authors: Harbeck N,Untch M,Pache L,Eiermann W

    更新日期:1994-03-01 00:00:00

  • Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.

    abstract::Chemical structures of the sugar chains of various human alpha-fetoprotein (AFP) species with different affinity for Concanavalin A (Con A) and Lens culinaris agglutinin (LCA) were examined by pyridylamination of their oligosaccharides and stepwise exoglycosidase digestion. Using reversed-phase and size-fractionation ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1993.91

    authors: Aoyagi Y,Suzuki Y,Igarashi K,Saitoh A,Oguro M,Yokota T,Mori S,Suda T,Isemura M,Asakura H

    更新日期:1993-03-01 00:00:00

  • Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients.

    abstract::The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604621

    authors: Panse J,Friedrichs K,Marx A,Hildebrandt Y,Luetkens T,Barrels K,Horn C,Stahl T,Cao Y,Milde-Langosch K,Niendorf A,Kröger N,Wenzel S,Leuwer R,Bokemeyer C,Hegewisch-Becker S,Atanackovic D

    更新日期:2008-09-16 00:00:00

  • Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project.

    abstract:BACKGROUND:Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes fr...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-01181-0

    authors: Millen GC,Arnold R,Cazier JB,Curley H,Feltbower RG,Gamble A,Glaser AW,Grundy RG,Lee LYW,McCabe MG,Phillips RS,Stiller CA,Várnai C,Kearns PR

    更新日期:2020-12-10 00:00:00

  • Chromosome rearrangements in synovial chondromatous lesions.

    abstract::Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.346

    authors: Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

    更新日期:1996-07-01 00:00:00

  • A prospective study of peri-diagnostic and surgical wait times for patients with presumptive colorectal, lung, or prostate cancer.

    abstract::The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604819

    authors: Grunfeld E,Watters JM,Urquhart R,O'Rourke K,Jaffey J,Maziak DE,Morash C,Patel D,Evans WK

    更新日期:2009-01-13 00:00:00

  • Effects of administration of basic fibroblast growth factor on hypoxic fractions in xenografted DLD-2 human tumours: time dependence.

    abstract::A previous publication (Leith et al., 1992) showed that administration of basic fibroblast growth factor (FGF-2, 0.25 mg kg-1, q.i.d. x 7) to mice bearing xenografted DLD-2 human colon cancers would increase treated tumour growth rates as compared to control neoplasms. Additionally, at the end of the 7 day treatment p...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1993.418

    authors: Leith JT,Michelson S

    更新日期:1993-10-01 00:00:00

  • A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer.

    abstract::Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase II clinical trial in patients with advanced renal cancer to determine...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1038/sj.bjc.6601321

    authors: Madhusudan S,Protheroe A,Propper D,Han C,Corrie P,Earl H,Hancock B,Vasey P,Turner A,Balkwill F,Hoare S,Harris AL

    更新日期:2003-10-20 00:00:00

  • KRAS mutational status affects oxaliplatin-based chemotherapy independently from basal mRNA ERCC-1 expression in metastatic colorectal cancer patients.

    abstract:BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2012.526

    authors: Basso M,Strippoli A,Orlandi A,Martini M,Calegari MA,Schinzari G,Di Salvatore M,Cenci T,Cassano A,Larocca LM,Barone C

    更新日期:2013-01-15 00:00:00