Abstract:
:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attending the Royal Marsden and Mayday University Hospital genetic counselling services and 62 matched GP attenders (controls). Levels of general psychological morbidity were found to be similar between cases and controls; however, cases reported significantly higher breast cancer-specific distress despite clinic attendance [mean (s.d.) total Impact of Event Scale score, 14.1 (14.3) cases; 2.4 (6.7) controls, P < 0.001]. Although cases perceived themselves to be more susceptible to breast cancer, many women failed correctly to recall risk figures provided by the clinic; 66% could not accurately recall their own lifetime chance. Clinics appeared to have a positive impact on preventive behaviours and cases tended to engage more regularly in breast self-examination (monthly, 66% of cases vs 47% of controls), although few differences were found between groups in terms of health beliefs. We conclude that counselees and GP controls showed considerable similarities on many of the outcome measures, and risk of breast cancer was not predictive of greater psychological morbidity; although cases were more vulnerable to cancer-specific distress. Despite genetic counselling, many cases continued to perceive their risk of breast cancer inaccurately.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee Adoi
10.1038/bjc.1996.387subject
Has Abstractpub_date
1996-08-01 00:00:00pages
482-7issue
3eissn
0007-0920issn
1532-1827journal_volume
74pub_type
杂志文章abstract::This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604348
更新日期:2008-05-06 00:00:00
abstract::In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.189
更新日期:1984-09-01 00:00:00
abstract::Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1977.198
更新日期:1977-09-01 00:00:00
abstract::A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.1997.586
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TII...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0622-3
更新日期:2020-02-01 00:00:00
abstract::Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/bjc.1998.220
更新日期:1998-04-01 00:00:00
abstract::Forty-two patients with small cell lung cancer were treated with a combination of carboplatin, ifosfamide and etoposide. Vincristine was given on day 14 of each course, the courses being repeated every 28 days for a maximum of six. Thoracic radiotherapy was given 4 weeks after the last course of chemotherapy but no pr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.228
更新日期:1989-07-01 00:00:00
abstract::Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2016.115
更新日期:2016-05-24 00:00:00
abstract::Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.119
更新日期:1987-06-01 00:00:00
abstract::Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically conf...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604066
更新日期:2007-12-03 00:00:00
abstract::Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690323
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2013.408
更新日期:2013-08-20 00:00:00
abstract::Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.269
更新日期:1988-11-01 00:00:00
abstract::To test the feasibility and efficacy of epirubicin and ifosfamide added to first-line chemotherapy with cisplatin and paclitaxel in a phase II randomised clinical trial. Patients with histologically proven epithelial ovarian cancer were randomly assigned to receive first-line polychemotherapy with cisplatin/paclitaxel...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6604231
更新日期:2008-02-26 00:00:00
abstract:BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.336
更新日期:2015-10-20 00:00:00
abstract::Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.294
更新日期:1996-06-01 00:00:00
abstract::T-lymphocyte maturation associated protein, MAL, has been described as a tumour-suppressor gene with diagnostic value in colorectal and oesophageal cancers, and can be inactivated by promoter hypermethylation. The aim of this study was to analyse the prevalence of MAL promoter hypermethylation and the association with...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604777
更新日期:2008-12-02 00:00:00
abstract::The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.166
更新日期:1993-05-01 00:00:00
abstract::The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.205
更新日期:1981-09-01 00:00:00
abstract::HMGI-C belongs to the high-mobility-group-protein (HMG) family of architectural transcription factors and considerable interest has recently been shown in its expression in neoplastic tissues and apparent involvement in tumorigenesis. We could previously demonstrate an expression of HMGI-C mRNA in the peripheral blood...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600935
更新日期:2003-05-06 00:00:00
abstract::Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1363
更新日期:2000-09-01 00:00:00
abstract::We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.103
更新日期:1994-03-01 00:00:00
abstract::Chemical structures of the sugar chains of various human alpha-fetoprotein (AFP) species with different affinity for Concanavalin A (Con A) and Lens culinaris agglutinin (LCA) were examined by pyridylamination of their oligosaccharides and stepwise exoglycosidase digestion. Using reversed-phase and size-fractionation ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.91
更新日期:1993-03-01 00:00:00
abstract::The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604621
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes fr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01181-0
更新日期:2020-12-10 00:00:00
abstract::Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.346
更新日期:1996-07-01 00:00:00
abstract::The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604819
更新日期:2009-01-13 00:00:00
abstract::A previous publication (Leith et al., 1992) showed that administration of basic fibroblast growth factor (FGF-2, 0.25 mg kg-1, q.i.d. x 7) to mice bearing xenografted DLD-2 human colon cancers would increase treated tumour growth rates as compared to control neoplasms. Additionally, at the end of the 7 day treatment p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.418
更新日期:1993-10-01 00:00:00
abstract::Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase II clinical trial in patients with advanced renal cancer to determine...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.bjc.6601321
更新日期:2003-10-20 00:00:00
abstract:BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.526
更新日期:2013-01-15 00:00:00