Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line.

abstract：:The aim of this study was to determine the dose-limiting toxicity (DLT) and establish the recommended dose for mitomycin C added every 3 weeks to the standard combination dose of capecitabine. Cohorts of at least three patients with pretreated gastrointestinal carcinoma received capecitabine 1000 mg m(-2) orally twice...

journal_title：British journal of cancer

authors： Hofheinz RD,Hartmann JT,Willer A,Oechsle K,Hartung G,Gnad U,Saussele S,Kreil S,Bokemeyer C,Hehlmann R,Hochhaus A

更新日期：2004-08-31 00:00:00

abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...

journal_title：British journal of cancer

authors： Depuydt CE,Vereecken AJ,Salembier GM,Vanbrabant AS,Boels LA,van Herck E,Arbyn M,Segers K,Bogers JJ

更新日期：2003-02-24 00:00:00

abstract：:The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed ...

journal_title：British journal of cancer

authors： Southey MC,Tesoriero AA,Andersen CR,Jennings KM,Brown SM,Dite GS,Jenkins MA,Osborne RH,Maskiell JA,Porter L,Giles GG,McCredie MR,Hopper JL,Venter DJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:There is no consensus agreement regarding optimal management of locally excised ductal carcinoma in situ (DCIS) or features of greatest assistance in predicting disease behaviour. Cases in the UKCCCR/ANZ DCIS trial have been histologically reviewed to determine the features of prognostic importance. METHOD:...

journal_title：British journal of cancer

authors： Pinder SE,Duggan C,Ellis IO,Cuzick J,Forbes JF,Bishop H,Fentiman IS,George WD,UK Coordinating Committee on Cancer Research (UKCCCR) Ductal Carcinoma In Situ (DCIS) Working Party.

更新日期：2010-06-29 00:00:00

abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...

journal_title：British journal of cancer

authors： Baeuerle PA,Gires O

更新日期：2007-02-12 00:00:00

abstract：BACKGROUND:The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS:We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adeno...

journal_title：British journal of cancer

authors： Strell C,Norberg KJ,Mezheyeuski A,Schnittert J,Kuninty PR,Moro CF,Paulsson J,Schultz NA,Calatayud D,Löhr JM,Frings O,Verbeke CS,Heuchel RL,Prakash J,Johansen JS,Östman A

更新日期：2017-06-27 00:00:00

abstract：:The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival....

journal_title：British journal of cancer

authors： Cole DJ,Brown DC,Crossley E,Alcock CJ,Gatter KC

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Previous studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive breast cancer (IBC) is lower. The aim of this study is to characterise HER2 status in DCIS and assess its prognostic value. METHODS:HER2 status was evaluated in a large ...

journal_title：British journal of cancer

authors： Miligy IM,Toss MS,Gorringe KL,Lee AHS,Ellis IO,Green AR,Rakha EA

更新日期：2019-05-01 00:00:00

abstract：:In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...

journal_title：British journal of cancer

authors： Bracarda S,Porta C,Sisani M,Marrocolo F,Paglino C,Hamzaj A,D Buono S,Sternberg CN

更新日期：2015-01-06 00:00:00

abstract：:In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; greater than 80% B5 positive) and individuals with no known tumour (total 247; less than 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tigh...

journal_title：British journal of cancer

authors： Metcalfe S,Milner J,Svvennsen RJ

更新日期：1984-03-01 00:00:00

abstract：:In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patie...

journal_title：British journal of cancer

authors： Planting AS,van der Burg ME,van den Bent MJ,de Boer-Dennert M,Stoter G,Verweij J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated...

journal_title：British journal of cancer

authors： Lesnock JL,Darcy KM,Tian C,Deloia JA,Thrall MM,Zahn C,Armstrong DK,Birrer MJ,Krivak TC

更新日期：2013-04-02 00:00:00

abstract：:Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemo...

journal_title：British journal of cancer

authors： Hone P,Edwards A,Halls J,Cox R,Lloyd D

更新日期：2003-06-16 00:00:00

abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

journal_title：British journal of cancer

authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

更新日期：2010-02-16 00:00:00

abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...

journal_title：British journal of cancer

authors： Ray-Coquard I,Philip T,de Laroche G,Froger X,Suchaud JP,Voloch A,Mathieu-Daudé H,Fervers B,Farsi F,Browman GP,Chauvin F

更新日期：2002-02-01 00:00:00

abstract：:The WWOX (WW-domain containing oxidoreductase) is a candidate tumour suppressor gene spanning the same chromosome region, 16q23, as the second most common fragile site (FS), FRA16D. Deletions detected by comparative genomic hybridisation (CGH) and loss of heterozygosity at microsatellite markers on chromosome 16q are ...

journal_title：British journal of cancer

authors： Park SW,Ludes-Meyers J,Zimonjic DB,Durkin ME,Popescu NC,Aldaz CM

更新日期：2004-08-16 00:00:00

abstract：:The in vitro deamination, cytotoxicity, cellular drug uptake, distribution and cellular pharmacology in HL-60 cells of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a lipophilic derivative of arabinofuranosylcytosine (ara-C), were studied. Compared with ara-C, NHAC in liposomal formulations was highly resista...

journal_title：British journal of cancer

authors： Horber DH,Schott H,Schwendener RA

更新日期：1995-05-01 00:00:00

abstract：:The present study was designed in order to evaluate the response rate and the toxicity of continuous infusion of Interleukin 2 (IL2) in patients over 65 with metastatic renal cell carcinoma. Twenty-five patients, median age 69 (range 65-77), without any prior systemic anticancer therapy received a continuous infusion ...

journal_title：British journal of cancer

authors： Négrier S,Mercatello A,Bret M,Thiesse P,Blay JY,Coronel B,Merrouche Y,Oskam R,Franks CR,Clavel M

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric canc...

journal_title：British journal of cancer

authors： Einama T,Homma S,Kamachi H,Kawamata F,Takahashi K,Takahashi N,Taniguchi M,Kamiyama T,Furukawa H,Matsuno Y,Tanaka S,Nishihara H,Taketomi A,Todo S

更新日期：2012-06-26 00:00:00

abstract：:Hepatocyte growth factor (HGF), through Met receptor binding, fulfils numerous functions in invasive tumour growth (survival/proliferation, motility, apoptosis), but epigenetic control of gene expression in this process is poorly understood. In HGF-treated breast cancer cells we studied (a) the chemoinvasion towards C...

journal_title：British journal of cancer

authors： Ridolfi E,Matteucci E,Maroni P,Desiderio MA

更新日期：2008-11-18 00:00:00

abstract：:Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-us...

journal_title：British journal of cancer

authors： Jernström H,Frenander J,Fernö M,Olsson H

更新日期：1999-07-01 00:00:00

abstract：:The records of 610 consecutive patients with small cell lung cancer, treated on a common protocol in a multicentre trial, were reviewed and 24 (4%) cases of spinal cord compression identified. Five hundred patients had isotope bone scans performed at presentation, and in 131 (26%) there was abnormal isotope uptake in ...

journal_title：British journal of cancer

authors： Goldman JM,Ash CM,Souhami RL,Geddes DM,Harper PG,Spiro SG,Tobias JS

更新日期：1989-04-01 00:00:00

abstract：:This randomised trial compared platinum-based to anthracycline-based chemotherapy in patients with small-cell lung cancer (limited or extensive stage) and

journal_title：British journal of cancer

authors： Baka S,Califano R,Ferraldeschi R,Aschroft L,Thatcher N,Taylor P,Faivre-Finn C,Blackhall F,Lorigan P

更新日期：2008-08-05 00:00:00

abstract：:Two policies of palliative thoracic radiotherapy for non-small-cell lung cancer have been compared in a randomised multicentre controlled trial. A total of 369 patients with inoperable, histologically or cytologically confirmed disease, too advanced for radical 'curative' radiotherapy, and with their main symptoms rel...

journal_title：British journal of cancer

authors：

更新日期：1991-02-01 00:00:00

abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...

journal_title：British journal of cancer

authors： Djuzenova CS,Mühl B,Fehn M,Oppitz U,Müller B,Flentje M

更新日期：2006-04-24 00:00:00

abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

journal_title：British journal of cancer

authors： Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...

journal_title：British journal of cancer

authors： van der Bij S,Schaake E,Koffijberg H,Burgers JA,de Mol BA,Moons KG

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. ME...

journal_title：British journal of cancer

authors： Sgaramella N,Coates PJ,Strindlund K,Loljung L,Colella G,Laurell G,Rossiello R,Muzio LL,Loizou C,Tartaro G,Olofsson K,Danielsson K,Fåhraeus R,Nylander K

更新日期：2015-07-14 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Despite the widespread use of neoadjuvant chemotherapy in breast cancer patients, prediction of individual response to treatment remains an unsolved clinical problem. Particularly, administration of an inefficient chemotherapeutic regimen should be avoided. Therefore, a better understanding of the molecular ...

journal_title：British journal of cancer

authors： Michlmayr A,Bachleitner-Hofmann T,Baumann S,Marchetti-Deschmann M,Rech-Weichselbraun I,Burghuber C,Pluschnig U,Bartsch R,Graf A,Greil R,Allmaier G,Steger G,Gnant M,Bergmann M,Oehler R

更新日期：2010-10-12 00:00:00