Carcinoma of the cervix uteri: an assessment of the relationship of tumour proliferation to prognosis.

abstract：:The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...

journal_title：British journal of cancer

authors： Gustafson P,Baldetorp B,Fernö M,Akerman M

更新日期：1999-03-01 00:00:00

abstract：:Two soft-agar methods for assaying chemosensitivity of human cancers in vitro were compared with respect to colony morphology, plating efficiency (PE) and chemosensitivity of human melanomas. In 9 xenografts and 9 patients' biopsy specimens Method A (essentially that of Courtenay & Mills, 1978) gave considerably highe...

journal_title：British journal of cancer

authors： Tveit KM,Endresen L,Rugstad HE,Fodstad O,Pihl A

更新日期：1981-10-01 00:00:00

abstract：:The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in patients with advanced disease confirmed that 105AD7 is non-toxic, and that T cell responses could be generated. A pros...

journal_title：British journal of cancer

authors： Maxwell-Armstrong CA,Durrant LG,Buckley TJ,Scholefield JH,Robins RA,Fielding K,Monson JR,Guillou P,Calvert H,Carmichael J,Hardcastle JD

更新日期：2001-06-01 00:00:00

abstract：:Endogamous groups in Western India have been known to have a wide degree of genetic diversity. Analysis of the data available on some of the endogamous groups belonging to two main communities attending the Tata Memorial Hospital, Bombay, viz. Hindus from Maharashtra, and Hindus from Gujarat show that one of the endog...

journal_title：British journal of cancer

authors： Jayant K,Balakrishnan V,Sanghvi LD

更新日期：1971-12-01 00:00:00

abstract：BACKGROUND:Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decrease...

journal_title：British journal of cancer

authors： Mull BB,Livingston JA,Patel N,Bui T,Hunt KK,Keyomarsi K

更新日期：2020-03-01 00:00:00

abstract：:Oral capecitabine is a highly active, well-tolerated and convenient treatment for breast and colorectal cancer. This trial assessed the efficacy and safety of single-agent capecitabine in patients with previously treated ovarian cancer. A total of 29 patients with platinum-pretreated relapsed ovarian cancer were enrol...

journal_title：British journal of cancer

authors： Vasey PA,McMahon L,Paul J,Reed N,Kaye SB

更新日期：2003-11-17 00:00:00

abstract：:Mismatch repair (MMR) deficiency in tumours from patients with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome is mainly caused by mutations in the MLH1, MSH2, and MSH6 genes. A major challenge in the clinical management of patients with suspected HNPCC is the frequent occurrence of missense mutations i...

journal_title：British journal of cancer

authors： Kariola R,Hampel H,Frankel WL,Raevaara TE,de la Chapelle A,Nyström-Lahti M

更新日期：2004-10-04 00:00:00

abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

journal_title：British journal of cancer

authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

更新日期：1995-07-01 00:00:00

abstract：:Trastuzumab is the only HER2/neu-directed therapy to have received Food and Drug Administration approval for the treatment of patients with metastatic breast cancer. The efficacy of trastuzumab depends on the HER2/neu status of the tumour and the patient's prior treatment, but even when patients are selected on the ba...

journal_title：British journal of cancer

authors： Fujita T,Doihara H,Kawasaki K,Takabatake D,Takahashi H,Washio K,Tsukuda K,Ogasawara Y,Shimizu N

更新日期：2006-01-30 00:00:00

abstract：:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and a...

journal_title：British journal of cancer

authors： Karsten U,Pilgrim G,Hanisch FG,Uhlenbruck G,Kasper M,Stosiek P,Papsdorf G,Pasternak G

更新日期：1988-08-01 00:00:00

abstract：:NIH3T3 cells transfected with c-H-ras and/or c-myc genes were examined for differences in drug sensitivity. The five transfectants used were N8, NIH3T3-nm-1, pT22-3-nm-2, pP1-4 and pT22-3. They were transfected with pKOneo alone, pKOneo and c-myc, pKOneo and c-myc plus activated c-H-ras, normal c-H-ras and activated c...

journal_title：British journal of cancer

authors： Niimi S,Nakagawa K,Yokota J,Tsunokawa Y,Nishio K,Terashima Y,Shibuya M,Terada M,Saijo N

更新日期：1991-02-01 00:00:00

abstract：:Bryostatin 1 is a novel macrocyclic lactone activator of protein kinase C (PKC) which has clinical potential as an anti-cancer agent. The mechanism of action of this agent is unknown, but protein kinase C has been implicated. In order to investigate this possibility, we have developed P388 sublines resistant to bryost...

journal_title：British journal of cancer

authors： Prendiville J,McGown AT,Gescher A,Dickson AJ,Courage C,Pettit GR,Crowther D,Fox BW

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The most significant problem of intra-arterial chemotherapy for advanced paranasal sinus carcinomas and residual cancers supplied by internal carotid artery (ICA) and involving the skull base is the lack of salvage therapies. OBJECTIVE:The objective of the study was to evaluate the usefulness of intra-arter...

journal_title：British journal of cancer

authors： Yokoyama J,Ohba S,Fujimaki M,Anzai T,Kojima M,Ikeda K,Suzuki M,Yoshimoto H,Inoue K

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC...

journal_title：British journal of cancer

authors： Yi M,Xu J,Liu P,Chang GJ,Du XL,Hu CY,Song Y,He J,Ren Y,Wei Y,Yang J,Hunt KK,Li X

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...

journal_title：British journal of cancer

authors： Hacker UT,Escalona-Espinosa L,Consalvo N,Goede V,Schiffmann L,Scherer SJ,Hedge P,Van Cutsem E,Coutelle O,Büning H

更新日期：2016-04-12 00:00:00

abstract：:Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min i.v. infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1-5) at one of nine dose levels: 24, 48, ...

journal_title：British journal of cancer

authors： Awada A,Punt CJ,Piccart MJ,Van Tellingen O,Van Manen L,Kerger J,Groot Y,Wanders J,Verweij J,Wagener DJ

更新日期：1999-03-01 00:00:00

abstract：:Patients with recurrent or refractory head and neck squamous cell carcinoma received cisplatin/epinephrine injectable gel or placebo gel injected directly into the clinically dominant tumour. The double-blind phase III trial comprised of up to 6 weekly treatments over 8 weeks, 4 weekly evaluation visits, and then mont...

journal_title：British journal of cancer

authors： Werner JA,Kehrl W,Pluzanska A,Arndt O,Lavery KM,Glaholm J,Dietz A,Dyckhoff G,Maune S,Stewart ME,Orenberg EK,Leavitt RD

更新日期：2002-10-21 00:00:00

abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...

journal_title：British journal of cancer

authors： Verma Y,Pradhan PK,Gurung N,Sapkota SD,Giri P,Sundas P,Bhattarai BN,Nadayil D,Ramnath T,Nandakumar A

更新日期：2012-02-28 00:00:00

abstract：:Increasingly, treatment choices leading to the same survival outcome can be offered to cancer patients (e.g. mastectomy or conservative surgery in early breast cancer). Two approaches available for post-orchidectomy, stage I patients with non-seminomatous germ cell tumours of the testis (NSGCTT), particularly those at...

journal_title：British journal of cancer

authors： Cullen MH,Billingham LJ,Cook J,Woodroffe CM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...

journal_title：British journal of cancer

authors： Stelwagen J,Lubberts S,Steggink LC,Steursma G,Kruyt LM,Donkerbroek JW,van Roon AM,van Gessel AI,van de Zande SC,Meijer C,Gräfin Zu Eulenburg CH,Oosting SF,Nuver J,Walenkamp AME,Jan de Jong I,Lefrandt JD,Gietema JA

更新日期：2020-11-01 00:00:00

abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...

journal_title：British journal of cancer

authors： Lorusso V,Crucitta E,Silvestris N,Catino A,Caporusso L,Mazzei A,Guida M,Latorre A,Sambiasi D,D'Amico C,Schittulli F,Calabrese P,De Lena M

更新日期：2003-02-24 00:00:00

abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...

journal_title：British journal of cancer

authors： Battersby S,Robertson BJ,Anderson TJ,King RJ,McPherson K

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant...

journal_title：British journal of cancer

authors： Jesinghaus M,Boxberg M,Wilhelm D,Münch S,Dapper H,Quante M,Schlag C,Lange S,Budczies J,Konukiewitz B,Mollenhauer M,Schlitter AM,Becker KF,Feith M,Friess H,Steiger K,Combs SE,Weichert W

更新日期：2019-12-01 00:00:00

abstract：:Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

journal_title：British journal of cancer

authors： Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

更新日期：1999-09-01 00:00:00

abstract：:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...

journal_title：British journal of cancer

authors： Dobrucki J,Bleehen NM

更新日期：1985-12-01 00:00:00

abstract：:All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findi...

journal_title：British journal of cancer

authors： Morrow RH,Pike MC,Smith PG

更新日期：1977-05-01 00:00:00

abstract：:Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch ...

journal_title：British journal of cancer

authors： Deng G,Peng E,Gum J,Terdiman J,Sleisenger M,Kim YS

更新日期：2002-02-12 00:00:00

abstract：:Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...

journal_title：British journal of cancer

authors： Marsden HB,Lennox EL,Lawler W,Kinnier-Wilson LM

更新日期：1980-06-01 00:00:00

abstract：:Patients with rectal cancer are at high risk of disease recurrence despite neoadjuvant radiochemotherapy with 5-Fluorouracil (5FU), a regimen that is now widely applied. In order to develop a regimen with increased antitumour activity, we previously established the recommended dose of neoadjuvant CPT-11 (three times w...

journal_title：British journal of cancer

authors： Voelter V,Zouhair A,Vuilleumier H,Matter M,Bouzourene H,Leyvraz S,Bauer J,Coucke P,Stupp R

更新日期：2006-09-18 00:00:00

abstract：:Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-depen...

journal_title：British journal of cancer

authors： Lau YS,Adamopoulos IE,Sabokbar A,Giele H,Gibbons CL,Athanasou NA

更新日期：2007-06-04 00:00:00