Abstract：
:Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line differentiated into macrophages (U937) cells). Phagocytic activity of U937phi cells was evaluated by flow-cytometry monitoring of ingestion of fluorescein-labelled Escherichia coli particles. Increase in irradiation fluence up to 3.45 mJ cm(-2) (corresponding irradiation time 15 s) resulted in significant increase in fluorescence signal (145%), while at higher light fluences the signal lowered down to the untreated control values. A light energy-dependent production of tumour necrosis factor-alpha (TNF-alpha) by photosensitized macrophages was further demonstrated using the L929 assay. The maximum TNF-alpha mediated cytolysis was observed at 28 mJ cm(-2) and was 1.7-fold greater than that in control. In addition, we demonstrated a fluence-dependent increase in nitric oxide (NO) production by mTHPC-photosensitized macrophages. NO release increased gradually and reached a plateau after irradiation fluence of 6.9 mJ cm(-2). Cytotoxicity measurements indicated that the observed manifestations of mTHPC-photosensitized macrophage activation took place under the sublethal light doses. The relevance of the present findings to clinical mTHPC-PDT is discussed.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin Fdoi
10.1038/sj.bjc.6690648subject
Has Abstractpub_date
1999-09-01 00:00:00pages
37-42issue
1eissn
0007-0920issn
1532-1827journal_volume
81pub_type
杂志文章abstract：:The aim of this study was to find a procedure allowing estimation of individual pharmacokinetic parameters for adriamycin with minimal cost and disturbance for the patient. Twenty-five patients with breast cancer were treated by short infusion of adriamycin at a dose of 12 mg m-2 week-1 (41 courses). Population charac...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.226
更新日期：1989-07-01 00:00:00
abstract：:Experiments were conducted to determine whether bladder cancer would develop in primates (Papio sp.) infected with S. haematobium and concurrently exposed to low initiating doses of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). To control for the systemic effects of schistosomiasis, 5 baboons wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.308
更新日期：1980-11-01 00:00:00
abstract：:In this population-based Norwegian cohort study (2.1 million children), the impact of birth and parental characteristics on the risk of neuroblastoma (178 cases) was evaluated. In children below the age of 18 months, there was an increased neuroblastoma risk among those with congenital malformations and suggestion of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604646
更新日期：2008-10-07 00:00:00
abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603668
更新日期：2007-04-10 00:00:00
abstract：:We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 63 cases of primary laryngeal squamous cell carcinoma. MeHPLAase activity did not show any correlation with oestrogen, progesterone and epidermal growth factor (EGF) receptor levels. No significant relationship was found between MeHPLAase activi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.210
更新日期：1998-04-01 00:00:00
abstract：:Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.408
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2011.7
更新日期：2011-02-15 00:00:00
abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605520
更新日期：2010-02-16 00:00:00
abstract：BACKGROUND:To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS:PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2017.262
更新日期：2017-10-10 00:00:00
abstract：BACKGROUND:The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD:We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cis...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6605618
更新日期：2010-03-30 00:00:00
abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602822
更新日期：2005-11-14 00:00:00
abstract：BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0162-2
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS:The DII was calculated from a baseline food freque...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.98
更新日期：2016-05-24 00:00:00
abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.828
更新日期：2014-03-04 00:00:00
abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.379
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.114
更新日期：2011-04-26 00:00:00
abstract：:The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.216
更新日期：1989-07-01 00:00:00
abstract：:The phenotypic expression of cells derived from human anaplastic astrocytomas, rat glioma, normal human adult and foetal brain tissue have been examined for differentiated and malignancy-associated properties. Glial fibrillary acidic protein (GFAP), high affinity glutamate and gamma-amino butyric acid (GABA) uptake an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.44
更新日期：1984-03-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603428
更新日期：2006-11-20 00:00:00
abstract：:The treatment of breast cancer patients has changed rapidly in the past decade, but empirical data at local and national level are scarce. Predicting the consequences of screening for primary treatment is consequently difficult. The aim of this analysis of records on admissions to hospital of women with breast cancer ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.466
更新日期：1994-12-01 00:00:00
abstract：:Hyper-activation of mitogen-activated protein kinase (MAPK) has recently been reported in several human cancers and activation of MAPK in those cancers may be associated with carcinogenesis through aberrant cell proliferation. To understand the roles of the MAPK pathway in colorectal tumorigenesis, we examined the sta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690817
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.585
更新日期：2013-02-19 00:00:00
abstract：:In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.189
更新日期：1984-09-01 00:00:00
abstract：:In addition to cobalt, metallic nickel, cadmium and other metals (e.g. zinc and copper) dissolve when incubated with horse serum at 37°. The dissolving property of copper in serum resembles that of cobalt, its solubility being increased greatly in the presence of oxygen, whereas the solubilities of cadmium, zinc and m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1972.38
更新日期：1972-08-01 00:00:00
abstract：:We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6603843
更新日期：2007-07-02 00:00:00
abstract：:The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.424
更新日期：1996-09-01 00:00:00
abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.16
更新日期：1987-01-01 00:00:00
abstract：:Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.45
更新日期：1976-03-01 00:00:00
abstract：:In Vaud, Switzerland, the incidence of carcinoids based on 218 malignant and 215 benign cases rose from 19.6/10(6)in 1974-85 to 28. 2/10(6)in 1986-97, more so among males and malignant neoplasms. Lung was the commonest site for malignant and large intestine for benign carcinoids. Sixty-eight (16%) carcinoids had anoth...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1394
更新日期：2000-10-01 00:00:00
abstract：:The aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epirubicin intravenously on day 1 and a fixed dose of gemcitabine on days ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1054/bjoc.1999.1003
更新日期：2000-02-01 00:00:00
