Abstract：
:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive than those in aggregates, probably due to the different physical properties of the membrane of flat cells attached to the substratum. Cell-cell contact appears to affect the heat sensitivity of HT29 cells possibly by means of inducing arrest in a heat resistant phase of the cell cycle.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Dobrucki J,Bleehen NMdoi
10.1038/bjc.1985.268subject
Has Abstractpub_date
1985-12-01 00:00:00pages
849-55issue
6eissn
0007-0920issn
1532-1827journal_volume
52pub_type
杂志文章abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.219
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2014.654
更新日期：2015-03-31 00:00:00
abstract：:Somatostatin analogues may be useful novel agents in the systemic treatment of advanced colorectal cancer, as somatostatin inhibits proliferation in a wide variety of cell types. Here, we report the expression profiles of somatostatin receptor mRNAs in 32 pairs of malignant and normal colonic epithelia. Receptor subty...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.59
更新日期：1997-01-01 00:00:00
abstract：:Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1956
更新日期：2001-09-01 00:00:00
abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604315
更新日期：2008-04-22 00:00:00
abstract：:Some cancer cells depend on the function of specific molecules for their growth, survival, and metastatic potential. Targeting of these critical molecules has arguably been the best therapy for cancer as demonstrated by the success of tamoxifen and trastuzumab in breast cancer. This review will evaluate the type I IGF...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602963
更新日期：2006-02-27 00:00:00
abstract：:Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690563
更新日期：1999-07-01 00:00:00
abstract：:The formation of cyclic AMP was studied in normal liver, subcutaneous hepatomas derived from MH1C1 cells, and premalignant liver and primary hepatomas induced by the carcinogens 2-acetylaminofluorene (AAF) and 4-dimethylamino-azobenzene (DAB). While only very slight effects of prostaglandins (PG) were seen in slices o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.281
更新日期：1978-12-01 00:00:00
abstract：:Over the period 1966-1995, based on 11,662 patients, the incidence of squamous cell carcinoma of the skin increased three to four times in Norway mainly as a result of an increased number of localized tumours. In men, cancer of the auricle was the second most common site; in women the incidence was low. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690725
更新日期：1999-10-01 00:00:00
abstract：:Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and im...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.167
更新日期：1998-03-01 00:00:00
abstract：:A prospective, consecutive study of the aetiology of treatment-associated diarrhoea was conducted in 25 patients with disseminated germ cell cancer treated with intensive chemotherapy. Clostridium difficile was isolated in 45% of the diarrhoea episodes, which makes this species the most important bacterial pathogen in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.334
更新日期：1992-10-01 00:00:00
abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604621
更新日期：2008-09-16 00:00:00
abstract：:In addition to hypoxia, acidic extracellular pH (pH(e)) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601766
更新日期：2004-05-04 00:00:00
abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602171
更新日期：2004-10-18 00:00:00
abstract：:The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6600247
更新日期：2002-04-22 00:00:00
abstract：BACKGROUND:The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer vaccine trials based on the CT antigens, MAGE-A3 and NY-ESO-1, are being carried out. METHODS:We used specific q-RT-PCR assays to analyse the expression of the CT...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.215
更新日期：2012-06-26 00:00:00
abstract：:We determined the prevalence of type-specific hrHPV infections in the Netherlands on cervical scrapes of 45 362 women aged 18-65 years. The overall hrHPV prevalence peaked at the age of 22 with peak prevalence of 24%. Each of the 14 hrHPV types decreased significantly with age (P-values between 0.0009 and 0.03). The p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604162
更新日期：2008-02-12 00:00:00
abstract：:Recent studies indicate that cancer antigen 125 (CA125) response criteria tend to overestimate a tumour reduction measured by standard WHO response criteria in recurrent epithelial ovarian carcinoma. The aim of the study was to validate the recently introduced GCIG (The Gynaecological Cancer Intergroup) CA125 response...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601501
更新日期：2004-01-26 00:00:00
abstract：:Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.138
更新日期：1975-07-01 00:00:00
abstract：:The chick embryo was used to study the relationship between the onset of tumour neovascularization and tumour growth. Walker 256 carcinosarcoma was implanted on the chrioallantoic membrane (CAM) of about 600 embryos aged 5-16 days. Tumour diameter and changes in the CAM vasculature in response to the implants were rec...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.49
更新日期：1977-03-01 00:00:00
abstract：:Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600877
更新日期：2003-04-22 00:00:00
abstract：:The Second Meeting of the British Society for Immunology Tumour Immunology Affinity Group (TIAG) took place at King's College (London, UK) on 17-18 June 1997 and brought together over 100 tumour immunologists from the UK and abroad. In contrast to previous meetings the focus of the meeting was on the role of adhesion ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1998.300
更新日期：1998-06-01 00:00:00
abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.158
更新日期：1986-07-01 00:00:00
abstract：:I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.97
更新日期：1982-04-01 00:00:00
abstract：:The relationship between history of schistosomiasis and bladder cancer risk was investigated using data from a case-control study conducted between January 1994 and July 1996 in Alexandria, Egypt. Cases were 190 subjects with incident, histologically confirmed invasive cancer of the bladder, and controls were 187 subj...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.197
更新日期：1998-04-01 00:00:00
abstract：:In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.68
更新日期：1982-03-01 00:00:00
abstract：BACKGROUND:To describe the prescription patterns of analgesics during the last 3 months of life in lung cancer and to determine the associated factors. METHODS:Data on lung cancer patients (N=10,202) who died during 2000-2008 were extracted from the General Practice Research Database (GPRD). This database records pres...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.150
更新日期：2011-05-24 00:00:00
abstract：BACKGROUND:The prognostic and predictive value of multiple serum biomarkers was evaluated using samples from a randomised phase III study (HORIZON II) investigating chemotherapy with or without cediranib in metastatic colorectal cancer (mCRC). METHODS:Baseline levels of 207 protein markers were measured in serum sampl...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2013.649
更新日期：2013-11-26 00:00:00
abstract：BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0580-9
更新日期：2019-11-01 00:00:00
abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603298
更新日期：2006-08-21 00:00:00
