当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > A phase III placebo-controlled study in advanced head and neck cancer using intratumoural cisplatin/epinephrine gel.

A phase III placebo-controlled study in advanced head and neck cancer using intratumoural cisplatin/epinephrine gel.

Abstract：

:Patients with recurrent or refractory head and neck squamous cell carcinoma received cisplatin/epinephrine injectable gel or placebo gel injected directly into the clinically dominant tumour. The double-blind phase III trial comprised of up to 6 weekly treatments over 8 weeks, 4 weekly evaluation visits, and then monthly follow-up; open-label dosing began as needed after three blinded treatments. Tumour response was defined as complete (100% regression) or partial (50-99% regression) sustained for > or =28 day, and patient benefit as attainment of palliative or preventive goals prospectively selected by investigators and patients. With cisplatin/epinephrine gel, 25% (14 out of 57) of tumours responded (16% complete regression, 9% partial regression), vs 3% (one out of 35, complete regression) with placebo (P=0.007). Patient benefit was positively associated with target tumour response in the blinded period among cisplatin/epinephrine gel recipients (P=0.024): 43% (six out of 14) of responders benefited, vs 12% (five out of 43) of non-responders. The most frequent adverse event was pain during injection and the next most frequent was local cytotoxic effects consistent with the gel's mode of action. Systemic adverse events typical of intravenous cisplatin were uncommon. Intratumoural therapy with cisplatin/epinephrine gel provided safe, well-tolerated, effective palliative treatment for patients with locally advanced head and neck squamous cell carcinoma, who lack other satisfactory treatment options.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Werner JA,Kehrl W,Pluzanska A,Arndt O,Lavery KM,Glaholm J,Dietz A,Dyckhoff G,Maune S,Stewart ME,Orenberg EK,Leavitt RD

doi

10.1038/sj.bjc.6600588

subject

Has Abstract

pub_date

2002-10-21 00:00:00

pages

938-44

issue

9

eissn

0007-0920

issn

1532-1827

journal_volume

87

pub_type

临床试验,杂志文章,随机对照试验

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Mutational analysis of the CDKN2 gene in metastases from patients with cutaneous malignant melanoma.

    abstract：:We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.59

    authors： Platz A,Ringborg U,Lagerlöf B,Lundqvist E,Sevigny P,Inganäs M

    更新日期：1996-02-01 00:00:00

  • Chromosome complement and SV40 transformation of cells from patients susceptible to malignant disease.

    abstract：:A comparative study has been made of fibroblasts obtained from patients with differing susceptibilities to malignant disease, both with respect to their chromosome complements and their transformation with SV40 virus. Fibroblasts from 2 Bloom's syndrome patients were found not to have raised SV40 transformation rates ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.235

    authors： Webb T,Harding M

    更新日期：1977-11-01 00:00:00

  • The influence of invasive growth pattern and microvessel density on prognosis in colorectal cancer and colorectal liver metastases.

    abstract：:The nature of the invasive growth pattern and microvessel density (MVD) have been suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal liver metastases. The purpose of the present study was to determine whether these two histological features were interrelated and to assess their r...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603677

    authors： Rajaganeshan R,Prasad R,Guillou PJ,Chalmers CR,Scott N,Sarkar R,Poston G,Jayne DG

    更新日期：2007-04-10 00:00:00

  • Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies.

    abstract：:Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/sj.bjc.6605003

    authors： Velentzis LS,Cantwell MM,Cardwell C,Keshtgar MR,Leathem AJ,Woodside JV

    更新日期：2009-05-05 00:00:00

  • A prospective study of serum bile acid concentrations and colorectal cancer risk in post-menopausal women on the island of Guernsey.

    abstract：:Secondary bile acids produced by the action of the colonic microflora may increase risk of colorectal cancer. Serum bile acid concentrations reflect the faecal bile acid profile and may be of value as biomarkers of risk of colorectal cancer. In a pilot investigation we examined: (i) the reproducibility of measurements...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600340

    authors： Costarelli V,Key TJ,Appleby PN,Allen DS,Fentiman IS,Sanders TA

    更新日期：2002-06-05 00:00:00

  • Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation.

    abstract：:Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperative radiotherapy of locally advanced head and neck cancer was investigated. The value of T(pot) in predicting th...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6600119

    authors： Awwad HK,Lotayef M,Shouman T,Begg AC,Wilson G,Bentzen SM,Abd El-Moneim H,Eissa S

    更新日期：2002-02-12 00:00:00

  • Effective delivery of Complex Innovative Design (CID) cancer trials-A consensus statement.

    abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...

    journal_title：British journal of cancer

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1038/s41416-019-0653-9

    authors： Blagden SP,Billingham L,Brown LC,Buckland SW,Cooper AM,Ellis S,Fisher W,Hughes H,Keatley DA,Maignen FM,Morozov A,Navaie W,Pearson S,Shaaban A,Wydenbach K,Kearns PR,Experimental Cancer Medicine Centres (ECMC) CID trials wo

    更新日期：2020-02-01 00:00:00

  • Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells.

    abstract：BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.188

    authors： Martín V,Sanchez-Sanchez AM,Herrera F,Gomez-Manzano C,Fueyo J,Alvarez-Vega MA,Antolín I,Rodriguez C

    更新日期：2013-05-28 00:00:00

  • Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.

    abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.193

    authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

    更新日期：2016-07-26 00:00:00

  • Multiple primary tumours in a population-based series of patients with histopathologically peer-reviewed sarcomas.

    abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.512

    authors： Hartley AL,Blair V,Harris M,Birch JM,Banerjee SS,Freemont AJ,McClure J,McWilliam LJ

    更新日期：1993-12-01 00:00:00

  • Robot-assisted radical prostatectomy vs laparoscopic and open retropubic radical prostatectomy: functional outcomes 18 months after diagnosis from a national cohort study in England.

    abstract：BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.454

    authors： Nossiter J,Sujenthiran A,Charman SC,Cathcart PJ,Aggarwal A,Payne H,Clarke NW,van der Meulen J

    更新日期：2018-02-20 00:00:00

  • The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

    abstract：:The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.729

    authors： Houba PH,Boven E,Erkelens CA,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期：1998-12-01 00:00:00

  • Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.

    abstract：:Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.79

    authors： Ridge SA,Sludden J,Wei X,Sapone A,Brown O,Hardy S,Canney P,Fernandez-Salguero P,Gonzalez FJ,Cassidy J,McLeod HL

    更新日期：1998-01-01 00:00:00

  • Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance.

    abstract：:Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VE...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603108

    authors： Onesto C,Hannoun-Lévi JM,Chamorey E,Formento JL,Ramaioli A,Pagès G

    更新日期：2006-05-22 00:00:00

  • Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma.

    abstract：BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.27

    authors： Kurihara M,Kirita T,Sasahira T,Ohmori H,Matsushima S,Yamamoto K,Bosserhoff AK,Kuniyasu H

    更新日期：2013-04-16 00:00:00

  • Recruitment of ethnic minorities into cancer clinical trials: experience from the front lines.

    abstract：:Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2012.240

    authors： Symonds RP,Lord K,Mitchell AJ,Raghavan D

    更新日期：2012-09-25 00:00:00

  • Phase II study of nedaplatin and irinotecan with concurrent thoracic radiotherapy in patients with locally advanced non-small-cell lung cancer.

    abstract：BACKGROUND:Current international guidelines recommend the use of platinum-based chemotherapy with thoracic radiotherapy (TRT) for patients with locally advanced non-small-cell lung cancer (NSCLC). METHODS:Patients with unresectable stage IIIA or IIIB NSCLC were treated with nedaplatin (NP) at 50 mg m(-2) and irinoteca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605875

    authors： Oshita F,Ohe M,Honda T,Murakami S,Kondo T,Saito H,Noda K,Yamashita K,Nakayama Y,Yamada K

    更新日期：2010-10-26 00:00:00

  • Evaluation of MSA as a serum marker in breast cancer: a comparison with CEA.

    abstract：:In a blind study, 518 serum samples were assayed for serum levels of mammary serum antigen (MSA) by an enzyme immunoassay (EIA) using the 3E1.2 monoclonal antibody. Using 300 IU as the arbitrary cut off to distinguish normal from abnormal individuals, 75% of patients with primary Stage I carcinoma of the breast (n = 1...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1988.66

    authors： Stacker SA,Sacks NP,Golder J,Tjandra JJ,Thompson CH,Smithyman A,McKenzie IF

    更新日期：1988-03-01 00:00:00

  • Clinical value of R-spondins in triple-negative and metaplastic breast cancers.

    abstract：BACKGROUND:RSPO ligands, activators of the Wnt/β-catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). METHODS:Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT-PCR. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.131

    authors： Coussy F,Lallemand F,Vacher S,Schnitzler A,Chemlali W,Caly M,Nicolas A,Richon S,Meseure D,El Botty R,De-Plater L,Fuhrmann L,Dubois T,Roman-Roman S,Dangles-Marie V,Marangoni E,Bièche I

    更新日期：2017-06-06 00:00:00

  • Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph node metastasis.

    abstract：:The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR) techniques. The expression of u-...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.588

    authors： Yoshino H,Endo Y,Watanabe Y,Sasaki T

    更新日期：1998-09-01 00:00:00

  • Molecular alterations in a patient with Turcot's syndrome.

    abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.379

    authors： Rochlitz CF,Heide I,de Kant E,Neubauer A,Schmidt CA,Neuhaus P,Huhn D,Herrmann R

    更新日期：1993-09-01 00:00:00

  • Type distribution, viral load and integration status of high-risk human papillomaviruses in pre-stages of cervical cancer (CIN).

    abstract：:A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602648

    authors： Andersson S,Safari H,Mints M,Lewensohn-Fuchs I,Gyllensten U,Johansson B

    更新日期：2005-06-20 00:00:00

  • Immunofluorescent detection of hormone receptors in cutaneous melanocytic tumours.

    abstract：:Immunofluorescent assessment of hormone receptors in melanocytic tumours is quite feasible without loss of diagnostic material, in contrast to the impracticability of quantitative biochemical assays. Using this method, oestrogen receptors were demonstrated in 4/6, and progesterone receptors in 3/5 patients with metast...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.95

    authors： Thompson AJ,Cook MG,Gill PG

    更新日期：1981-05-01 00:00:00

  • Systemic immune-inflammation index in germ-cell tumours.

    abstract：BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.460

    authors： Chovanec M,Cierna Z,Miskovska V,Machalekova K,Kalavska K,Rejlekova K,Svetlovska D,Macak D,Spanik S,Kajo K,Babal P,De Giorgi U,Mego M,Mardiak J

    更新日期：2018-03-20 00:00:00

  • Sigma-2 receptors as a biomarker of proliferation in solid tumours.

    abstract：:Over the past several years, our group has provided considerable evidence that the expression of sigma-2 (sigma2) receptors may serve as a biomarker of tumour cell proliferation. In these in vitro studies, sigma2 receptors were expressed 8-10 times more in proliferative (P) tumour cells than in quiescent (Q) tumour ce...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.1067

    authors： Wheeler KT,Wang LM,Wallen CA,Childers SR,Cline JM,Keng PC,Mach RH

    更新日期：2000-03-01 00:00:00

  • HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer.

    abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2017.220

    authors： Barnes TA,Amir E

    更新日期：2017-08-08 00:00:00

  • Activation and activities of the p53 tumour suppressor protein.

    abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1054/bjoc.2001.2128

    authors： Bálint E E,Vousden KH

    更新日期：2001-12-14 00:00:00

  • Are GPs under-investigating older patients presenting with symptoms of ovarian cancer? Observational study using General Practice Research Database.

    abstract：BACKGROUND:Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rates using ovarian cancer as an example. METHODS:From the General Practi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605593

    authors： Tate AR,Nicholson A,Cassell JA

    更新日期：2010-03-16 00:00:00

  • Quality of life during chemotherapy in lung cancer patients: results across different treatment lines.

    abstract：BACKGROUND:Most lung cancer patients are diagnosed at an advanced disease stage and predominantly receive palliative treatment, which increasingly consists of several chemotherapy lines. We report on patients' quality of life (QOL) to gain knowledge on QOL during and across multiple lines of chemotherapy. This includes...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.585

    authors： Wintner LM,Giesinger JM,Zabernigg A,Sztankay M,Meraner V,Pall G,Hilbe W,Holzner B

    更新日期：2013-10-29 00:00:00

  • Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistance-associated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3.

    abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.27

    authors： Martell RL,Slapak CA,Levy SB

    更新日期：1997-01-01 00:00:00