Effective delivery of Complex Innovative Design (CID) cancer trials-A consensus statement.

abstract：:Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988...

journal_title：British journal of cancer

authors： Bucchi L,Barchielli A,Ravaioli A,Federico M,De Lisi V,Ferretti S,Paci E,Vettorazzi M,Patriarca S,Frigerio A,Buiatti E,SCREENREG Working Group.

更新日期：2005-01-17 00:00:00

abstract：BACKGROUND:Tumoural interstitial hypertension, possibly modulated by platelet-derived and vascular endothelial growth factor receptors (PDGFR and VEGFR), may mediate resistance to chemotherapy. METHODS:Forty-eight patients with advanced solid tumours received oral PDGFR inhibitor CP-868,596 (60-100 mg twice daily (BID...

journal_title：British journal of cancer

authors： Michael M,Vlahovic G,Khamly K,Pierce KJ,Guo F,Olszanski AJ

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases...

journal_title：British journal of cancer

authors： Martínez-Campa C,González A,Mediavilla MD,Alonso-González C,Alvarez-García V,Sánchez-Barceló EJ,Cos S

更新日期：2009-11-03 00:00:00

abstract：:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...

journal_title：British journal of cancer

authors： Mattern J,Bak M Jr,Hoever KH,Volm M

更新日期：1988-07-01 00:00:00

abstract：:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...

journal_title：British journal of cancer

authors： van Rijn J,van den Berg J,Teerlink T,Kruyt FA,Schor DS,Renardel de Lavalette AC,van den Berg TK,Jakobs C,Slotman BJ

更新日期：2003-02-10 00:00:00

abstract：:Clinical-pathologic-genetic studies were performed on 3 kindreds showing the familial atypical multiple mole-melanoma syndrome (FAMMM). Findings showed vertical transmission, including father-to-son, of cutaneous malignant melanoma and/or FAMMM moles with no sex predilection. A broad spectrum of clinical signs charact...

journal_title：British journal of cancer

authors： Lynch HT,Fusaro RM,Pester J,Lynch JF

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:To compare the imaging and clinical features of temporal lobe necrosis (TLN) in nasopharyngeal carcinoma (NPC) patients treated with two-dimensional radiotherapy (2D-RT) or those with intensity-modulated radiotherapy (IMRT). METHODS:We retrospectively analysed NPC patients who underwent 2D-RT (72 patients, ...

journal_title：British journal of cancer

authors： Mao YP,Zhou GQ,Liu LZ,Guo R,Sun Y,Li L,Lin AH,Zeng MS,Kang TB,Jia WH,Shao JY,Mai HQ,Ma J

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...

journal_title：British journal of cancer

authors： Nicoud MB,Sterle HA,Massari NA,Táquez Delgado MA,Formoso K,Herrero Ducloux MV,Martinel Lamas D,Cremaschi GA,Medina VA

更新日期：2020-02-01 00:00:00

abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

journal_title：British journal of cancer

authors： Woods LM,Rachet B,Cooper N,Coleman MP

更新日期：2007-04-10 00:00:00

abstract：:Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carragee...

journal_title：British journal of cancer

authors： Sordelli DO,Fontán PA,Meiss RP,Ruggiero RA,Bustuoabad OD

更新日期：1989-11-01 00:00:00

abstract：:Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major influence affecting outcome. Children with tumours confined to the tissue of origin with no evidence of nodal or metastati...

journal_title：British journal of cancer

authors： Kingston JE,McElwain TJ,Malpas JS

更新日期：1983-08-01 00:00:00

abstract：:PS2, an oestrogen-inducible protein, was measured in the cytosol of 230 primary tumours from patients who were subjected to first-line tamoxifen therapy for advanced disease without prior adjuvant therapy with tamoxifen. PS2 correlated positively with oestrogen receptor (ER, P < 0.01) and progesterone receptor content...

journal_title：British journal of cancer

authors： Foekens JA,Portengen H,Look MP,van Putten WL,Thirion B,Bontenbal M,Klijn JG

更新日期：1994-12-01 00:00:00

abstract：:A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Laurén classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the str...

journal_title：British journal of cancer

authors： Setälä LP,Kosma VM,Marin S,Lipponen PK,Eskelinen MJ,Syrjänen KJ,Alhava EM

更新日期：1996-09-01 00:00:00

abstract：:Question prompt lists (QPLs) have been shown to be an inexpensive and effective communication tool for patients in oncology consultations. We aimed to develop and pilot a QPL for palliative care (PC) patients. In order to identify suitable questions for inclusion in the QPL, we conducted focus groups and individual in...

journal_title：British journal of cancer

authors： Clayton J,Butow P,Tattersall M,Chye R,Noel M,Davis JM,Glare P

更新日期：2003-12-01 00:00:00

abstract：:Advances in understanding the role of vascular endothelial growth factor (VEGF) in normal physiology are giving insight into the basis of adverse effects attributed to the use of VEGF inhibitors in clinical oncology. These effects are typically downstream consequences of suppression of cellular signalling pathways imp...

journal_title：British journal of cancer

authors： Kamba T,McDonald DM

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:CD26 is a multifunctional membrane-bound glycoprotein that regulates tumour growth in addition to its other activities. Because disease aggressiveness is correlated with CD26 expression in several T-cell malignancies, we decided to investigate the invasiveness of cells expressing different levels of CD26. M...

journal_title：British journal of cancer

authors： Havre PA,Abe M,Urasaki Y,Ohnuma K,Morimoto C,Dang NH

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. METHODS:Canc...

journal_title：British journal of cancer

authors： Welch CA,Sweeting MJ,Lambert PC,Rutherford MJ,Jack RH,West D,Adlam D,Peake M

更新日期：2020-08-01 00:00:00

abstract：:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...

journal_title：British journal of cancer

authors： Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda K

更新日期：2001-09-28 00:00:00

abstract：BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...

journal_title：British journal of cancer

authors： Wang X,Zhao L,Liu H,Zhong D,Liu W,Shan G,Dong F,Gao W,Bai C,Li X

更新日期：2016-06-14 00:00:00

abstract：:Fifteen human glioma cell lines were examined for their sensitivity to 1,3-bis(chloroethyl)-nitrosourea (BCNU, carmustine) and cis-dichlorodiamminoplatinum (cisplatin), the induction of DNA interstrand cross-linking (DNA-ISC) induced by the two agents and cellular O6-alkylguanine alkyltransferase (ATase) activity. Cel...

journal_title：British journal of cancer

authors： Beith J,Hartley J,Darling J,Souhami R

更新日期：1997-01-01 00:00:00

abstract：:We used a nested case-control design on data from men in four prospective studies (from the UK, Maryland in the USA, and two from Finland) with available stored serum samples to determine whether there was an advantage in measuring both free prostate-specific antigen (PSA) and total PSA as a potential screening test f...

journal_title：British journal of cancer

authors： Wald NJ,Watt HC,George L,Knekt P,Helzlsouer KJ,Tuomilehto J

更新日期：2000-02-01 00:00:00

abstract：:Findings in humans and animal models suggest that in utero hormonal and dietary exposures increase later breast cancer risk. Since alcohol intake by adult women consistently increases their breast cancer risk, we wondered whether maternal alcohol consumption during pregnancy increases female offspring's mammary tumori...

journal_title：British journal of cancer

authors： Hilakivi-Clarke L,Cabanes A,de Assis S,Wang M,Khan G,Shoemaker WJ,Stevens RG

更新日期：2004-06-01 00:00:00

abstract：:Apurinic/apyrimidinic (AP) sites in DNA are potentially lethal and mutagenic. They can arise spontaneously or following DNA damage from reactive oxygen species or alkylating agents, and they constitute a significant product of DNA damage following cellular exposure to ionizing radiation. The major AP endonuclease resp...

journal_title：British journal of cancer

authors： Herring CJ,Deans B,Elder RH,Rafferty JA,MacKinnon J,Barzilay G,Hickson ID,Hendry JH,Margison GP

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...

journal_title：British journal of cancer

authors： Belin L,Tan A,De Rycke Y,Dechartres A

更新日期：2020-05-01 00:00:00

abstract：:In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...

journal_title：British journal of cancer

authors： Richel DJ,Colly LP,Kluin-Nelemans JC,Willemze R

更新日期：1991-07-01 00:00:00

abstract：:Detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with Corynebacterium parvum (C. parvum). These patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. They all received an initial i.v. inf...

journal_title：British journal of cancer

authors： James K,Clunie GJ,Woodruff MF,McBride WH,Stimson WH,Drew R,Catty D

更新日期：1975-09-01 00:00:00

abstract：:Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb/C mice. Time cou...

journal_title：British journal of cancer

authors： Kamm YJ,Peters GJ,Hull WE,Punt CJ,Heerschap A

更新日期：2003-08-18 00:00:00

abstract：BACKGROUND:Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent. METHODS:We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales ...

journal_title：British journal of cancer

authors： Kroll ME,Stiller CA,Murphy MF,Carpenter LM

更新日期：2011-11-22 00:00:00

abstract：:In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...

journal_title：British journal of cancer

authors： Williams-Smith DL,Payne LN,Wyard SJ

更新日期：1984-09-01 00:00:00